1.
Eur J Med Chem
; 166: 125-135, 2019 Mar 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30703656
RESUMEN
A selectively antimycobacterial compound belonging to the nitrofuran class of antimicrobials has been developed via conjugation of the nitrofuran moiety to a series of spirocyclic piperidines through an amide linkage. It proved to have comparable activity against drug-sensitive (H37Rv) strain as well as multidrug-resistant, patient-derived strains of Mycobacterium tuberculosis. The compound is druglike, showed no appreciable cytotoxicity toward human retinal pigment epithelial cell line ARPE-19 in concentrations up to 100⯵M and displayed low toxicity when evaluated in mice.