RESUMEN
2 new flavonoid glycosides, kaempferol 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-ß-D-glucopyranoside (1) and quercetin 3-O-(4",6"-di-O-α-L-rhamnopyranosyl)-ß-D-glucopyranoside (2), were isolated from the n-butanol soluble fraction of the methanol extract (BF) of Astragalus abyssinicus aerial parts, together with 3 known compounds, rutin (3), kaempferol 3-O-ß-D-rutinoside (4) and 5,7,4'-trihydroxy-3'-methoxyisoflavone (5). The structures of the isolated compounds were characterized on the basis of UV, NMR and negative ESI-MS analyses. The BF fraction showed in vitro weak antibacterial activity against Staphylococcus aureus, while 2 and 3 exhibited in vitro antioxidant activity higher than ascorbic acid using DPPH free radical scavenging activity method.
Asunto(s)
Planta del Astrágalo/química , Flavonoides/farmacología , Glicósidos/farmacología , Componentes Aéreos de las Plantas/química , Extractos Vegetales/farmacología , Antioxidantes/química , Antioxidantes/aislamiento & purificación , Antioxidantes/farmacología , Flavonoides/química , Flavonoides/aislamiento & purificación , Glicósidos/química , Glicósidos/aislamiento & purificación , Quempferoles/química , Quempferoles/aislamiento & purificación , Quempferoles/farmacología , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Extractos Vegetales/química , Quercetina/análogos & derivados , Quercetina/química , Quercetina/aislamiento & purificación , Quercetina/farmacología , Trisacáridos/química , Trisacáridos/aislamiento & purificación , Trisacáridos/farmacologíaRESUMEN
In the present work, a computational study for the optimized molecular structural parameters, thermo-chemical parameters, total dipole moment, HOMO-LUMO energy gap and a combined experimental and computational study for FT-IR spectra for 2-(2-furanylmethylene) propanedinitrile have been investigated using B3LYP utilizing 6-31G and 6-311G basis set. Our calculated results showed that the investigated compound possesses a dipole moment of 7.5D and HOMO-LUMO energy gap of 3.92eV using B3LYP/6-311G which indicates that our investigated compound is highly applicable for photovoltaic solar cell applications.
Asunto(s)
Furanos/química , Nitrilos/química , Espectroscopía Infrarroja por Transformada de Fourier , Modelos Moleculares , Conformación Molecular , Teoría Cuántica , Energía SolarRESUMEN
In the present work, a combined experimental and computational study for the optimized molecular structural parameters, FT-IR spectra, thermo-chemical parameters, total dipole moment and HOMO-LUMO energy gap for 2-chloro-5-(2,5-dimethoxy-benzylidene)-1,3-diethyl-dihydro-pyrimidine-4,6(1H,5H)-dione have been investigated using B3LYP/6-311G basis set. Our calculated results have showed that the investigated compound possesses a dipole moment of 4.9 Debye and HOMO-LUMO energy gap of 3 eV which indicate high recommendations for photovoltaic devices fabrication.
Asunto(s)
Pirimidinas/química , Pirimidinonas/química , Vibración , Cinética , Modelos Moleculares , Conformación Molecular , Teoría Cuántica , Espectroscopía Infrarroja por Transformada de Fourier , TermodinámicaRESUMEN
Two new flavonol glycosides were isolated from dried leaves of Koelreuteria paniculata Laxm. (Sapindaceae) and characterized as 6,8-dihydroxy-afzelin and afzelin 3"-O-gallate, based on chemical and spectral evidences, in addition to nine known polyphenolic metabolites, including eight isolated for the first time from this species.
Asunto(s)
Flavonoides/química , Glicósidos/química , Quempferoles , Plantas Medicinales/química , Proantocianidinas , Egipto , Flavonoides/aislamiento & purificación , Glicósidos/aislamiento & purificación , Espectroscopía de Resonancia Magnética , Espectrometría de Masas , Hojas de la Planta/química , Espectrofotometría UltravioletaRESUMEN
Two novel triterpenoid saponins, Snatzkein C, (3beta, 20-dihydroxylupan-28-oic acid 3-O-[beta-D-galactopyranosyl-(1-->2)-beta-D-glucopyranosyl-28- O-beta-D-glucopyranoside) and Snatzkein D, (3beta, 20-dihydroxylupan-28-oic acid 3-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl]-28-O-beta-D-++ +glucopyranoside), have been isolated from Arenaria filicaulis. Their structure and conformational behaviour were elucidated by one- and two-dimensional 1H NMR and 13C NMR spectroscopy.
Asunto(s)
Saponinas/química , Triterpenos/química , Conformación de Carbohidratos , Secuencia de Carbohidratos , Modelos Moleculares , Conformación Molecular , Datos de Secuencia Molecular , Resonancia Magnética Nuclear Biomolecular , Saponinas/aislamiento & purificación , Triterpenos/aislamiento & purificaciónRESUMEN
Four novel triterpenoid saponins have been isolated from Gypsophila capillaris. Three were monodesmosidic: 3 beta-hydroxyolean-12-en-23,28-dioic acid 28-O-[beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->2)] [beta-D-galactopyranosyl(1-->6)]beta-D-glucopyranoside, 3 beta-hydroxyolean-12-en-23-oxo-28-oic acid 28-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-galactopyranosyl-(1-->3)] [beta-D-glucopyranosyl(1-->6)]beta-D-galactopyranoside, 3 beta-hydroxyolean-12-en-23,28-dioic acid 28-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-galactopyranosyl-(1-->3)] [beta-D-glucopyranosyl(1-->6)]beta-D-galactopyranoside. The fourth was bisdesmosidic: 3 beta-hydroxyolean-12-en-23,28-dioic acid 23-O-beta-D-glucopyranosyl-28-O-[beta-D-glucopyranosyl-(1-->2)-beta-D- galactopyranosyl-(1-->3)][beta-D-glucopyranosyl-(1-->6)]beta-D- galactopyranoside. The structures of the compounds were elucidated by 1D and 2D NMR techniques and from other spectroscopic evidence.
Asunto(s)
Plantas Medicinales/química , Saponinas/química , Triterpenos/química , Conformación de Carbohidratos , Secuencia de Carbohidratos , Egipto , Espectroscopía de Resonancia Magnética , Datos de Secuencia Molecular , Estructura Molecular , Oligosacáridos/química , Oligosacáridos/aislamiento & purificación , Saponinas/aislamiento & purificación , Espectrometría de Masa Bombardeada por Átomos Veloces , Triterpenos/aislamiento & purificaciónAsunto(s)
Alimentos Formulados/normas , Alimentos/normas , Leche , Animales , Peso Corporal , Caseínas , Carbohidratos de la Dieta , Grasas de la Dieta , Digestión , OvinosRESUMEN
1. Suckling lambs maintained for 4 weeks on a milk-substitute diet containing 407 g Toprina yeast/kg dry matter of diet exhibited poor growth, low appetite and extensive renal damage. 2. The batch of yeast used contained 2065 mg zinc/kg. 3. The kidneys of lambs offered a milk diet supplemented with the same Zn content as the yeast-fed diet (32-1 mg Zn/1000 kJ) were similarly affected.