Classification of breast tumors by using a novel approach based on deep learning methods and feature selection.

PURPOSE: Cancer is one of the most insidious diseases that the most important factor in overcoming the cancer is early diagnosis and detection. The histo-pathological images are used to determine whether the tissue is cancerous and the type of cancer. As the result of examination on tissue images by the expert personnel, the cancer type, and stage of the tissue can be determined. However, this situation can cause both time and energy loss as well as personnel-related inspection errors. By the increased usage of computer-based decision methods in the last decades, it would be more efficient and accurate to detect and classify the cancerous tissues with computer-aided systems. METHODS: As classical image processing methods were used for cancer-type detection in early studies, advanced deep learning methods based on recurrent neural networks and convolutional neural networks have been used more recently. In this paper, popular deep learning methods such as ResNet-50, GoogLeNet, InceptionV3, and MobilNetV2 are employed by implementing novel feature selection method in order to classify cancer type on a local binary class dataset and multi-class BACH dataset. RESULTS: The classification performance of the proposed feature selection implemented deep learning methods follows as for the local binary class dataset 98.89% and 92.17% for BACH dataset which is much better than most of the obtained results in literature. CONCLUSION: The obtained findings on both datasets indicates that the proposed methods can detect and classify the cancerous type of a tissue with high accuracy and efficiency.

Use of Silver Nitrate Application as Mini-Invasive Treatment of Pilonidal Sinus Disease.

OBJECTIVES: To investigate the cure rate and adverse effects of silver nitrate application for treatment of pilonidal sinus disease (PSD). Methods: Number of sinus pit orifices, and complications with silver nitrate application and debridement for sacrococcygeal PSD between January 2015 and July 2018 were analyzed in this retrospective study. Data were obtained from surgical, discharge, and outpatient follow-up records. Among 56 patients who were treated with silver nitrate stick, 11 patients with incomplete hospital records were excluded from the study. Demographic data including age, gender, length of follow-up, number of silver nitrate applications, number of involved sinuses and recurrence and complication rates were recorded. Results were expressed as frequencies, means, and range of values. The Mann Whitney U and chi square tests were used to evaluate significance. Results: Mean age was 24.3 +- 5.18 (range, 14 - 36) years, and recurrence occurred in 4 (8.9%) patients. Complications developed in 10 (22.2%) patients and included abscess, erythema, and necrosis in 5 (11.1%), 2 (4.4%), and 3 (6.6%) patients, respectively. The recurrence rate was significantly higher in patients who developed abscesses during the follow-up period (p = 0.001) than those who did not. There was no statistically significant correlation between the recurrence rate and number of sinuses or the number of silver nitrate applications. CONCLUSION: Low morbidity and high healing rates achieved with silver nitrate provide support for this application as a feasible and effective conservative outpatient treatment for PSD in certain patients.

The role of syndecan-1 during endometrial carcinoma progression.

AIM: Syndecan-1 (CD138) has most extensively been studied and correlated with many types of cancers. CD138 is mainly expressed in epithelial cells and plasma cells. Quite a few previous studies have called attention to the expression status of CD138 in EC. We aimed to determine the location of CD138 in the hyperplasia and endometrial carcinoma progression scale, and its relation with proliferation via Ki67, and to identify a new criterion in the differential diagnosis of hyperplasia-carcinoma. MATERIALS AND METHODS: A total of 120 endometrial curettage materials with proliferative and secretory phase endometrium, hyperplasia without atypical, atypical hyperplasia, and endometrium carcinoma examined in the pathology laboratory between 1995 and 2016 were included in the study. Samples were subjected to immunostaining for CD138 and Ki67 using antibody. RESULTS: Statistical analysis revealed a significant and negative correlation between histopathological progression and CD138 (P < 0.01). Statistical analysis revealed a significant and positive correlation between histopathological progression and Ki67 (P < 0.01) and a significant negative correlation between Ki67 and CD138 (P < 0.01). CONCLUSION: CD138 may be helpful in diagnostic difficulties, and benign pathologies should be considered due to the increase in staining density. Furthermore, we believe that CD138 will be an important criterion in determining the risk of malignancy in hyperplasia, and the risk of malignancy progression may increase in cases, of which intensity of staining decreases in accordance with the normal endometrium.

Is ischemia-modified albumin a reliable tool for the assessment of acute pancreatitis?

PURPOSE: Oxidative stress has been implicated in several disorders, including acute pancreatitis (AP). Ischemia-modified albumin (IMA), which reflects the ability to bind cobalt, has been found to be elevated in conditions of oxidative stress and tissue hypoxia. This study examined IMA and adjusted IMA levels in patients with AP, and examined the associations of IMA and adjusted IMA levels to the severity of AP. PATIENTS AND METHODS: A total of 42 consecutive patients with AP and 43 age- and sex-matched control subjects were enrolled. Serum samples were obtained from patients with AP on admission as well as 48-72 hours after hospitalization, and from the controls, at the time of enrollment. Adjusted IMA was calculated by multiplying the IMA value of each patient with the ratio of the patient's albumin value and the median albumin value of the study population. The severity of AP was assessed according to the modified Atlanta classification, and the patients were divided into 2 groups: mild AP and severe AP. RESULTS: The serum IMA and adjusted IMA values of patients with AP on admission and those of the controls did not differ (p=0.86 and p=0.99, respectively). The second measurements of IMA and adjusted IMA in the AP group were higher than the first measurements of both the AP group and controls (for all, p<0.01). Among the IMA measurements, only adjusted IMA on admission had the ability to predict the severity of AP. Severe AP was correlated with albumin, and the area under the curve of adjusted IMA values on admission was 0.746 for differentiating patients with severe AP from mild AP with statistical significance (p=0.005). CONCLUSION: It was shown that IMA and adjusted IMA levels rise with the progression of AP. Lower levels of adjusted IMA predict the severity of AP. Further studies with serial measurements of IMA are warranted to explore the indicative role of IMA in the course of AP.

Diagnostic importance of CD56 with fine-needle aspiration cytology in suspected papillary thyroid carcinoma cases.

BACKGROUND: Palpable thyroid nodules can be found in 4%-7% of the adult population; however, <5% of thyroid nodules are malignant. Immunohistochemical markers, such as CD56, can be used to make a differential diagnosis between benign and malignant lesions. To increase the accuracy of the diagnosis and distinguish the malignant aspirates from the benign ones, chose to evaluate CD56, which is normally found in benign thyroid tissue. METHODS: A total of 53 fine-needle aspirate samples from patients diagnosed with suspected papillary thyroid carcinoma (PTC) were included prospectively. These aspirates were immunocytochemically stained for CD56. RESULTS: In histopathological examination, the fine-needle aspiration cytopathology specimens suspicious for PTC (after undergoing surgery) showed that 32 (60.4%) were benign and 21 (39.6%) were malignant. Thirty-one of the benign cases (96.87%) were CD56-positive, whereas the last case (3.13%) was CD56-negative. Staining was not seen in any of the malignant cases. CONCLUSIONS: We believe that CD56 is an important marker in the definitive diagnosis of suspected PTC cases, with CD56-positivity being interpreted in favor of benignity.

[Ectopic thyroid tissue localized in submandibular region]. / Submandibüler bölge yerlesimli ektopik tiroid dokusu.

An ectopic thyroid tissue is often localized in the midline between the foramen caecum and mediastinum, while it is rarely laterally localized. Submandibular location of thyroid tissue is extremely rare. In this article, we report a 56-year-old female case admitted with a painless, non-tender, and firm mass in the right submandibular region. The patient was operated. The mass was detected to be separate from the right lobe of the thyroid. The histopathological examination result was reported as an ectopic thyroid tissue. Ectopic thyroid tissues should be considered in the differential diagnosis of submandibular masses.

Pathological fractures on both lower limbs with Jaffe-Campanacci's syndrome.

Jaffe-Campanacci's syndrome is a very rare condition and was first described by Jaffe in 1958. It is presented by non-ossifying fibromas, café-au-lait spots and axillar freckling. Non-ossifying fibromas are usually found after minor traumas or stress fractures. Differential diagnosis to neurofibromatosis include the absence of Lisch granules, neurofibromatous skin lesions and schwannomatous soft tissue masses. In this case, we report a 13-year-old white boy with Jaffe-Campanacci's syndrome, and bilateral pathological lower limbs fracture.

Respiratory epithelial adenomatoid hamartoma associated with inflammatory nasal polyposis: a case report.

Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon benign lesion of the nasal cavity and paranasal sinuses. The etiology is unclear, however it is considered to be secondary to chronic sinonasal inflammation. Although it is rare, REAH should be taken into consideration in differential diagnosis of the nasal lesions. Complete surgical excision of the lesion is generally enough for the cure. A detailed pathological examination is necessary to prevent unnecessary surgical interventions. In this article, we present a 60-year-old female patient with REAH in the left nasal cavity associated with inflammatory polyp in the right nasal cavity.

Basal cell adenocarcinoma of the minor salivary gland: a case report.

Basal cell adenocarcinoma (BCA) is an uncommon salivary gland neoplasm. The majority of salivary gland tumors are located in the parotid gland, while only a few involves the minor salivary gland of the oral cavity. Pathological diagnosis is important to differentiate BCA from other neoplasms, as the prognosis of the diseases is significantly different. In this article, we present a 41-year-old-male with BCA involving the upper labial mucosa.