RESUMEN
In patients with acute acetic acid intoxication the diminution of degree and velocity of thrombocytes aggregation against the background of their amount attenuation in peripheral blood is established. The significant augmentation of amount of lymphocytic thrombocytic complexes and -dimers concentration in blood is revealed. The most marked alterations are determined on first and second days in patients with severe degree of intoxication.
Asunto(s)
Ácido Acético/envenenamiento , Plaquetas/citología , Productos de Degradación de Fibrina-Fibrinógeno/análisis , Linfocitos/citología , Agregación Plaquetaria/efectos de los fármacos , Adulto , Adhesión Celular/efectos de los fármacos , Coagulación Intravascular Diseminada/sangre , Coagulación Intravascular Diseminada/etiología , Femenino , Humanos , Masculino , Intoxicación/sangre , Intoxicación/etiologíaRESUMEN
The patients experiencing severe acute poisoning with acetic acid were divided into 2 groups with and without exotoxic shock to study platelet aggregation capacity and lymphocyte-platelet adhesion. The data obtained were used to develop exotoxic shock probability coefficient for patients with acute poisoning.
Asunto(s)
Ácido Acético/envenenamiento , Plaquetas/fisiología , Linfocitos/fisiología , Agregación Plaquetaria , Choque/sangre , Choque/inducido químicamente , Enfermedad Aguda , Adulto , Adhesión Celular , Femenino , Humanos , Masculino , Pronóstico , Adulto JovenRESUMEN
AIM: To investigate immunity and lymphocytic-thrombocytic adhesion in pneumonia patients. MATERIAL AND METHODS: The examination of 59 male patients with pneumonia aged 18-21 years included calculation of total leucocyte count, lymphocyte subpopulations, relative and absolute count of lymphocytic-thrombocytic aggregates (LTA), measurement of IgA, IgM, IgG concentrations. RESULTS: Pneumonia patients have high count of leukocytes and low count of total and relative count of lymphocytes, low number of main lymphocytic subpopulations (CD4+, CD8+, CD16+, CD22+). Patients with uncomplicated pneumonia demonstrated high ability of lymphocytes for forming coaggregates with platelets. Patients with severe pneumonia complications may have either very high count of LTA (mean 403 +/- 45.6) or very low (mean 42.6 +/- 8.1). Percent of lymphocytes able to adhere to platelets (CD4+ with CD16+) in pneumonia is low. No correlation was found between LTA and the level of IgA, IgG, IgG. CONCLUSION: LTA is an objective indicator of cellular immunity status in pneumonia patients.
Asunto(s)
Subgrupos Linfocitarios/inmunología , Adhesividad Plaquetaria/inmunología , Neumonía/inmunología , Adolescente , Recuento de Células Sanguíneas , Adhesión Celular/inmunología , Humanos , Inmunidad , Inmunoglobulinas/sangre , Masculino , Neumonía/diagnóstico , Adulto JovenRESUMEN
Disseminated intravascular coagulation is a menacing complication due to acute acetic acid poisoning. However, many key mechanisms of this condition remain to be not clearly understood. The authors have studied lymphocyte-platelet adhesion and D-dimer concentrations in the blood. The most pronounced changes were observed in patients with severe poisoning in the first 24 hours, which were characterized by a significant increase in the number of lymphocyte-platelet complexes and D-dimer concentrations in the blood. A statistically significant correlation was established between the parameters being studied.