Pink noise promotes sooner state transitions during bimanual coordination.

The seemingly straightforward task of tying one's shoes requires a sophisticated interplay of joints, muscles, and neural pathways, posing a formidable challenge for researchers studying the intricacies of coordination. A widely accepted framework for measuring coordinated behavior is the Haken-Kelso-Bunz (HKB) model. However, a significant limitation of this model is its lack of accounting for the diverse variability structures inherent in the coordinated systems it frequently models. Variability is a pervasive phenomenon across various biological and physical systems, and it changes in healthy adults, older adults, and pathological populations. Here, we show, both empirically and with simulations, that manipulating the variability in coordinated movements significantly impacts the ability to change coordination patterns-a fundamental feature of the HKB model. Our results demonstrate that synchronized bimanual coordination, mirroring a state of healthy variability, instigates earlier transitions of coordinated movements compared to other variability conditions. This suggests a heightened adaptability when movements possess a healthy variability. We anticipate our study to show the necessity of adapting the HKB model to encompass variability, particularly in predictive applications such as neuroimaging, cognition, skill development, biomechanics, and beyond.

NONAN GaitPrint: An IMU gait database of healthy young adults.

An ongoing thrust of research focused on human gait pertains to identifying individuals based on gait patterns. However, no existing gait database supports modeling efforts to assess gait patterns unique to individuals. Hence, we introduce the Nonlinear Analysis Core (NONAN) GaitPrint database containing whole body kinematics and foot placement during self-paced overground walking on a 200-meter looping indoor track. Noraxon Ultium MotionTM inertial measurement unit (IMU) sensors sampled the motion of 35 healthy young adults (19-35 years old; 18 men and 17 women; mean ± 1 s.d. age: 24.6 ± 2.7 years; height: 1.73 ± 0.78 m; body mass: 72.44 ± 15.04 kg) over 18 4-min trials across two days. Continuous variables include acceleration, velocity, position, and the acceleration, velocity, position, orientation, and rotational velocity of each corresponding body segment, and the angle of each respective joint. The discrete variables include an exhaustive set of gait parameters derived from the spatiotemporal dynamics of foot placement. We technically validate our data using continuous relative phase, Lyapunov exponent, and Hurst exponent-nonlinear metrics quantifying different aspects of healthy human gait.

Temporal organization of stride-to-stride variations contradicts predictive models for sensorimotor control of footfalls during walking.

Walking exhibits stride-to-stride variations. Given ongoing perturbations, these variations critically support continuous adaptations between the goal-directed organism and its surroundings. Here, we report that stride-to-stride variations during self-paced overground walking show cascade-like intermittency-stride intervals become uneven because stride intervals of different sizes interact and do not simply balance each other. Moreover, even when synchronizing footfalls with visual cues with variable timing of presentation, asynchrony in the timings of the cue and footfall shows cascade-like intermittency. This evidence conflicts with theories about the sensorimotor control of walking, according to which internal predictive models correct asynchrony in the timings of the cue and footfall from one stride to the next on crossing thresholds leading to the risk of falling. Hence, models of the sensorimotor control of walking must account for stride-to-stride variations beyond the constraints of threshold-dependent predictive internal models.

Stride-to-stride time intervals are independently affected by the temporal pattern and probability distribution of visual cues.

The temporal structure of the variability of the stride-to-stride time intervals during paced walking is affected by the underlying autocorrelation function (ACF) of the pacing signal. This effect could be accounted for by differences in the underlying probability distribution function (PDF) of the pacing signal. We investigated the isolated and combined effect of the ACF and PDF of the pacing signals on the temporal structure of the stride-to-stride time intervals during visually guided paced overground walking. Ten young, healthy participants completed four walking trials while synchronizing their footstep to a visual pacing signal with a temporal pattern of either pink or white noise (different ACF) and either a Gaussian or normal probability distribution (different PDF). The scaling exponent from the Detrended Fluctuation Analysis was used to quantify the temporal structure of the stride-to-stride time intervals. The ACF and PDF of the pacing signals had independent effects on the scaling exponent of the stride-to-stride time intervals. The scaling exponent was higher during the pink noise pacing trials compared to the white noise pacing trials and higher during the trials with the Gaussian probability distribution compared to the uniform distribution. The results suggest that the sensorimotor system in healthy young individuals has an affinity towards external cues with a pink noise pattern and a Gaussian probability distribution during paced walking.

Noninvasive spinal stimulation safely enables upright posture in children with spinal cord injury.

In children with spinal cord injury (SCI), scoliosis due to trunk muscle paralysis frequently requires surgical treatment. Transcutaneous spinal stimulation enables trunk stability in adults with SCI and may pose a non-invasive preventative therapeutic alternative. This non-randomized, non-blinded pilot clinical trial (NCT03975634) determined the safety and efficacy of transcutaneous spinal stimulation to enable upright sitting posture in 8 children with trunk control impairment due to acquired SCI using within-subject repeated measures study design. Primary safety and efficacy outcomes (pain, hemodynamics stability, skin irritation, trunk kinematics) and secondary outcomes (center of pressure displacement, compliance rate) were assessed within the pre-specified endpoints. One participant did not complete the study due to pain with stimulation on the first day. One episode of autonomic dysreflexia during stimulation was recorded. Following hemodynamic normalization, the participant completed the study. Overall, spinal stimulation was well-tolerated and enabled upright sitting posture in 7 out of the 8 participants.

The temporal pattern and the probability distribution of visual cueing can alter the structure of stride-to-stride variability.

The structure of the stride-to-stride time intervals during paced walking can be altered by the temporal pattern of the pacing cues, however, it is unknown if an altered probability distribution of these cues could also affect stride-to-stride time intervals. We investigated the effect of the temporal pattern and probability distribution of visual pacing cues on the temporal structure of the variability of the stride-to-stride time intervals during walking. Participants completed self-paced walking (SPW) and walking paced by visual cueing that had a temporal pattern of either pink noise presented with a normal distribution (PNND), shuffled pink noise presented with a normal distribution (SPNND), white noise presented with a normal distribution (WNND), and white noise presented with a uniform distribution (WNUD). The temporal structure of the stride-to-stride time intervals was quantified using the scaling exponent calculated from Detrended Fluctuation Analysis. The scaling exponent was higher during the SPW and PNND trials than during the SPNND, WNND and WNUD trials and it was lower during the WNUD trial compared to the SPNND trial. The results revealed that both the temporal pattern and the probability distribution of the visual pacing cues can affect the scaling exponent of the variability of the stride-to-stride time intervals. This information is fundamental in understanding how visual input is involved in the control of gait.

Changes in human walking dynamics induced by uneven terrain are reduced with ongoing exposure, but a higher variability persists.

During walking, uneven terrain alters the action of the ground reaction force from stride to stride. The extent to which such environmental inconsistencies are withstood may be revealed by the regulation of whole-body angular momentum (L) during walking. L quantifies the balance of momenta of the body segments (thigh, trunk, etc.) about their combined center of mass, and remains close to zero during level walking. A failure to constrain L has been linked to falls. The aim of this study was to explore the ability of young adults to orchestrate their movement on uneven terrain, illustrated by the range of L (LR) and its variability (vLR). In eleven male adults, we observed significant increases in sagittal plane LR, and vLR in all three planes of motion during walking on an uneven in comparison to a flat surface. No reductions in these measures were observed within a 12-minute familiarisation period, suggesting that unimpaired adults either are unable to, or do not need to eliminate the effects of uneven terrain. Transverse plane LR, in contrast, was lower on immediate exposure, and then increased, pointing to the development of a less restrictive movement pattern, and would support the latter hypothesis.

Locomotor patterns change over time during walking on an uneven surface.

During walking, uneven surfaces impose new demands for controlling balance and forward progression at each step. It is unknown to what extent walking may be refined given an amount of stride-to-stride unpredictability at the distal level. Here, we explored the effects of an uneven terrain surface on whole-body locomotor dynamics immediately following exposure and after a familiarization period. Eleven young, unimpaired adults walked for 12 min on flat and uneven terrain treadmills. The whole-body center of mass excursion range (COMexc) and peak velocity (COMvel), step length and width were estimated. On first exposure to uneven terrain, we saw significant increases in medial-lateral COMexc and lateral COMvel, and in the variability of COMexc, COMvel and foot placement in both anterior-posterior and medial-lateral directions. Increases in step width and decreases in step length supported the immediate adoption of a cautious, restrictive solution on uneven terrain. After familiarization, step length increased and the variability of anterior-posterior COMvel and step length reduced, while step width and lateral COMvel reduced, alluding to a refinement of movement and a reduction of conservative strategies over time. However, the variability of medial-lateral COMexc and lateral COMvel increased, consistent with the release of previously constrained degrees of freedom. Despite this increase in variability, a strong relationship between step width and medial-lateral center of mass movement was maintained. Our results indicate that movement strategies of unimpaired adults when walking on uneven terrain can evolve over time with longer exposure to the surface.