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BACKGROUND: Previous deep learning-based studies were mainly conducted on detecting periapical lesions; limited information in classification, such as the periapical index (PAI) scoring system, is available. The study aimed to apply two deep learning models, Faster R-CNN and YOLOv4, in detecting and classifying periapical lesions using the PAI score from periapical radiographs (PR) in three different regions of the dental arch: anterior teeth, premolars, and molars. METHODS: Out of 2658 PR selected for the study, 2122 PR were used for training, 268 PR were used for validation and 268 PR were used for testing. The diagnosis made by experienced dentists was used as the reference diagnosis. RESULTS: The Faster R-CNN and YOLOv4 models obtained great sensitivity, specificity, accuracy, and precision for detecting periapical lesions. No clear difference in the performance of both models among these three regions was found. The true prediction of Faster R-CNN was 89%, 83.01% and 91.84% for PAI 3, PAI 4 and PAI 5 lesions, respectively. The corresponding values of YOLOv4 were 68.06%, 50.94%, and 65.31%. CONCLUSIONS: Our study demonstrated the potential of YOLOv4 and Faster R-CNN models for detecting and classifying periapical lesions based on the PAI scoring system using periapical radiographs.
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The spherical fuzzy set (SFS) model is one of the newly developed extensions of fuzzy sets (FS) for the purpose of dealing with uncertainty or vagueness in decision making. The aim of this paper is to define new exponential and Einstein exponential operational laws for spherical fuzzy sets and their corresponding aggregation operators. We introduce the operational laws for exponential and Einstein exponential SFSs in which the base values are crisp numbers and the exponents (weights) are spherical fuzzy numbers. Some of the properties and characteristics of the proposed operations are then discussed. Based on these operational laws, some new aggregation operators for the SFS model, namely Spherical Fuzzy Weighted Exponential Averaging (SFWEA) and Spherical Fuzzy Einstein Weighted Exponential Averaging (SFEWEA) operators are introduced. Finally, a decision-making algorithm based on these newly introduced aggregation operators is proposed and applied to a multi-criteria decision making (MCDM) problem related to ranking different types of psychotherapy.
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The exponential increase in the number of diabetics around the world has led to an equally large increase in the number of diabetic retinopathy (DR) cases which is one of the major complications caused by diabetes. Left unattended, DR worsens the vision and would lead to partial or complete blindness. As the number of diabetics continue to increase exponentially in the coming years, the number of qualified ophthalmologists need to increase in tandem in order to meet the demand for screening of the growing number of diabetic patients. This makes it pertinent to develop ways to automate the detection process of DR. A computer aided diagnosis system has the potential to significantly reduce the burden currently placed on the ophthalmologists. Hence, this review paper is presented with the aim of summarizing, classifying, and analyzing all the recent development on automated DR detection using fundus images from 2015 up to this date. Such work offers an unprecedentedly thorough review of all the recent works on DR, which will potentially increase the understanding of all the recent studies on automated DR detection, particularly on those that deploys machine learning algorithms. Firstly, in this paper, a comprehensive state-of-the-art review of the methods that have been introduced in the detection of DR is presented, with a focus on machine learning models such as convolutional neural networks (CNN) and artificial neural networks (ANN) and various hybrid models. Each AI will then be classified according to its type (e.g. CNN, ANN, SVM), its specific task(s) in performing DR detection. In particular, the models that deploy CNN will be further analyzed and classified according to some important properties of the respective CNN architectures of each model. A total of 150 research articles related to the aforementioned areas that were published in the recent 5 years have been utilized in this review to provide a comprehensive overview of the latest developments in the detection of DR. Supplementary Information: The online version contains supplementary material available at 10.1007/s10462-022-10185-6.
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Robotics is one of the most emerging technologies today, and are used in a variety of applications, ranging from complex rocket technology to monitoring of crops in agriculture. Robots can be exceptionally useful in a smart hospital environment provided that they are equipped with improved vision capabilities for detection and avoidance of obstacles present in their path, thus allowing robots to perform their tasks without any disturbance. In the particular case of Autonomous Nursing Robots, major essential issues are effective robot path planning for the delivery of medicines to patients, measuring the patient body parameters through sensors, interacting with and informing the patient, by means of voice-based modules, about the doctors visiting schedule, his/her body parameter details, etc. This paper presents an approach of a complete Autonomous Nursing Robot which supports all the aforementioned tasks. In this paper, we present a new Autonomous Nursing Robot system capable of operating in a smart hospital environment area. The objective of the system is to identify the patient room, perform robot path planning for the delivery of medicines to a patient, and measure the patient body parameters, through a wireless BLE (Bluetooth Low Energy) beacon receiver and the BLE beacon transmitter at the respective patient rooms. Assuming that a wireless beacon is kept at the patient room, the robot follows the beacon's signal, identifies the respective room and delivers the needed medicine to the patient. A new fuzzy controller system which consists of three ultrasonic sensors and one camera is developed to detect the optimal robot path and to avoid the robot collision with stable and moving obstacles. The fuzzy controller effectively detects obstacles in the robot's vicinity and makes proper decisions for avoiding them. The navigation of the robot is implemented on a BLE tag module by using the AOA (Angle of Arrival) method. The robot uses sensors to measure the patient body parameters and updates these data to the hospital patient database system in a private cloud mode. It also makes uses of a Google assistant to interact with the patients. The robotic system was implemented on the Raspberry Pi using Matlab 2018b. The system performance was evaluated on a PC with an Intel Core i5 processor, while the solar power was used to power the system. Several sensors, namely HC-SR04 ultrasonic sensor, Logitech HD 720p image sensor, a temperature sensor and a heart rate sensor are used together with a camera to generate datasets for testing the proposed system. In particular, the system was tested on operations taking place in the context of a private hospital in Tirunelveli, Tamilnadu, India. A detailed comparison is performed, through some performance metrics, such as Correlation, Root Mean Square Error (RMSE), and Mean Absolute Percentage Error (MAPE), against the related works of Deepu et al., Huh and Seo, Chinmayi et al., Alli et al., Xu, Ran et al., and Lee et al. The experimental system validation showed that the fuzzy controller achieves very high accuracy in obstacle detection and avoidance, with a very low computational time for taking directional decisions. Moreover, the experimental results demonstrated that the robotic system achieves superior accuracy in detecting/avoiding obstacles compared to other systems of similar purposes presented in the related works.
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One of the crucial problems in Industry 4.0 is how to strengthen the performance of mobile communication within mobile ad-hoc networks (MANETs) and mobile computational grids (MCGs). In communication, Industry 4.0 needs dynamic network connectivity with higher amounts of speed and bandwidth. In order to support multiple users for video calling or conferencing with high-speed transmission rates and low packet loss, 4G technology was introduced by the 3G Partnership Program (3GPP). 4G LTE is a type of 4G technology in which LTE stands for Long Term Evolution, followed to achieve 4G speeds. 4G LTE supports multiple users for downlink with higher-order modulation up to 64 quadrature amplitude modulation (QAM). With wide coverage, high reliability and large capacity, LTE networks are widely used in Industry 4.0. However, there are many kinds of equipment with different quality of service (QoS) requirements. In the existing LTE scheduling methods, the scheduler in frequency domain packet scheduling exploits the spatial, frequency, and multi-user diversity to achieve larger MIMO for the required QoS level. On the contrary, time-frequency LTE scheduling pays attention to temporal and utility fairness. It is desirable to have a new solution that combines both the time and frequency domains for real-time applications with fairness among users. In this paper, we propose a channel-aware Integrated Time and Frequency-based Downlink LTE Scheduling (ITFDS) algorithm, which is suitable for both real-time and non-real-time applications. Firstly, it calculates the channel capacity and quality using the channel quality indicator (CQI). Additionally, data broadcasting is maintained by using the dynamic class-based establishment (DCE). In the time domain, we calculate the queue length before transmitting the next packets. In the frequency domain, we use the largest weight delay first (LWDF) scheduling algorithm to allocate resources to all users. All the allocations would be taken placed in the same transmission time interval (TTI). The new method is compared against the largest weighted delay first (LWDF), proportional fair (PF), maximum throughput (MT), and exponential/proportional fair (EXP/PF) methods. Experimental results show that the performance improves by around 12% compared with those other algorithms.
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Corona viruses are a large family of viruses that are not only restricted to causing illness in humans but also affect animals such as camels, cattle, cats, and bats, thus affecting a large group of living species. The outbreak of Corona virus in late December 2019 (also known as COVID-19) raised major concerns when the outbreak started getting tremendous. While the first case was discovered in Wuhan, China, it did not take long for the disease to travel across the globe and infect every continent (except Antarctica), killing thousands of people. Since it has become a global concern, different countries have been working toward the treatment and generation of vaccine, leading to different speculations. While some argue that the vaccine may only be a few weeks away, others believe that it may take some time to create the vaccine. Given the increasing number of deaths, the COVID-19 has caused havoc worldwide and is a matter of serious concern. Thus, there is a need to study how the disease has been propagating across continents by numbers as well as by regions. This study incorporates a detailed description of how the COVID-19 outbreak started in China and managed to spread across the globe rapidly. We take into account the COVID-19 outbreak cases (confirmed, recovered, death) in order to make some observations regarding the pandemic. Given the detailed description of the outbreak, this study would be beneficial to certain industries that may be affected by the outbreak in order to take timely precautionary measures in the future. Further, the study lists some industries that have witnessed the impact of the COVID-19 outbreak on a global scale.
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In dental diagnosis, recognizing tooth complications quickly from radiology (e.g., X-rays) takes highly experienced medical professionals. By using object detection models and algorithms, this work is much easier and needs less experienced medical practitioners to clear their doubts while diagnosing a medical case. In this paper, we propose a dental defect recognition model by the integration of Adaptive Convolution Neural Network and Bag of Visual Word (BoVW). In this model, BoVW is used to save the features extracted from images. After that, a designed Convolutional Neural Network (CNN) model is used to make quality prediction. To evaluate the proposed model, we collected a dataset of radiography images of 447 patients in Hanoi Medical Hospital, Vietnam, with third molar complications. The results of the model suggest accuracy of 84% ± 4%. This accuracy is comparable to that of experienced dentists and radiologists.
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Quadratic cost functions estimation in the linear optimal control systems governed by differential equations (DEs) or partial differential equations (PDEs) has a well-established discipline in mathematics with many interfaces to science and engineering. During its development, the impact of uncertain phenomena to objective function and the complexity of the systems to be controlled have also increased significantly. Many engineering problems like magnetohydromechanical, electromagnetical and signal analysis for the transmission and propagation of electrical signals under uncertain environment can be dealt with. In this paper, we study the optimal control problem with operating a fractional DEs and PDEs at minimum quadratic objective function in the framework of neutrosophic environment and granular computing. However, there has been no studies appeared on the neutrosophic calculus of fractional order. Hence, we will introduce some derivatives of fractional order, including the neutrosophic Riemann-Liouville fractional derivatives and neutrosophic Caputo fractional derivatives. Next, we propose a new setting of two important problems in engineering. In the first problem, we investigate the numerical and exact solutions of some neutrosophic fractional DEs and neutrosophic telegraph PDEs. In the second problem, we study the optimality conditions together with the simulation of states of a linear quadratic optimal control problem governed by neutrosophic fractional DEs and PDEs. Some key applications to DC motor model and one-link robot manipulator model are investigated to prove the effectiveness and correctness of the proposed method.
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Similarity plays a significant implicit or explicit role in various fields. In some real applications in decision making, similarity may bring counterintuitive outcomes from the decision maker's standpoint. Therefore, in this research, we propose some novel similarity measures for bipolar and interval-valued bipolar neutrosophic set such as the cosine similarity measures and weighted cosine similarity measures. The propositions of these similarity measures are examined, and two multi-attribute decision making techniques are presented based on proposed measures. For verifying the feasibility of proposed measures, two numerical examples are presented in comparison with the related methods for demonstrating the practicality of the proposed method. Finally, we applied the proposed measures of similarity for diagnosing bipolar disorder diseases.
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Trastorno Bipolar/diagnóstico , Algoritmos , Toma de Decisiones , Estudios de Factibilidad , Lógica Difusa , HumanosRESUMEN
It is indeed necessary to design of an elderly support mobile healthcare and monitoring system on wireless sensor network (WSN) for dynamic monitoring. It comes from the need for maintenance of healthcare among patients and elderly people that leads to the demand on change in traditional monitoring approaches among chronic disease patients and alert on acute events. In this paper, we propose a new automated patient diagnosis called automated patient diagnosis (AUPA) using ATmega microcontrollers over environmental sensors. AUPA monitors and aggregates data from patients through network connected over web server and mobile network. The scheme supports variable data management and route establishment. Data transfer is established using adaptive route discovery and management approaches. AUPA supports minimizing packet loss and delay, handling erroneous data, and providing optimized decision-making for healthcare support. The performance of AUPA's QoS approach is tested using a set of health-related sensors which gather the patient's data over variable period of time and send from a source to destination AUPA node. Experimental results show that AUPA outperforms the existing schemes, namely SPIN and LEACH, with minimal signal loss rate and a better neighborhood node selection and link selection. It diminishes the jitter compared to the related algorithms. Graphical abstract Stack architecture of AUPA.
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Monitoreo Fisiológico/métodos , Telemedicina/métodos , Tecnología Inalámbrica , Algoritmos , Redes de Comunicación de Computadores , Diagnóstico por Computador , Electrocardiografía/instrumentación , Electromiografía/instrumentación , Humanos , Monitoreo Fisiológico/instrumentación , Programas Informáticos , Sudor , Dispositivos Electrónicos VestiblesRESUMEN
Introduction: The abnormal maxillary labial frenum is common in children during the primary or mixed dentition stage. A conventional surgery for this abnormality usually requires infiltration anesthesia which leads to fear in children and consequent noncooperation during the surgery. The aim of present study was to evaluate the reduction in the need of infiltration anesthesia, intraoperative bleeding control and postoperative pain and wound healing in children when using the diode laser for abnormal labial frenum in the maxilla. Methods: The present study was carried out among 30 children attending the Hanoi Medical University, Vietnam. A Diode Laser with 810 nm wavelength and power of 0.8 W was used for frenectomy. Results: The proportion of procedures without any need of infiltration anesthesia was 70%, while 93.34% of children demonstrated positive and very positive behavior. Proportion of indolence on the first day after surgery was 83.3%. While 83.3% of children did not take any analgesics, not a single child complained of any pain 3 days after surgery. Conclusion: Our results indicated that the use of diode laser showed several benefits in maxillary labial frenectomy in children. These included reducing the need of infiltration anesthesia, increasing the children's cooperation as well as decreasing the postoperative pain.
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This paper presents a system dedicated to monitoring the heart activity parameters using Electrocardiography (ECG) mobile devices and a Wearable Heart Monitoring Inductive Sensor (WHMIS) that represents a new method and device, developed by us as an experimental model, used to assess the mechanical activity of the hearth using inductive sensors that are inserted in the fabric of the clothes. Only one inductive sensor is incorporated in the clothes in front of the apex area and it is able to assess the cardiorespiratory activity while in the prior of the art are presented methods that predict sensors arrays which are distributed in more places of the body. The parameters that are assessed are heart data-rate and respiration. The results are considered preliminary in order to prove the feasibility of this method. The main goal of the study is to extract the respiration and the data-rate parameters from the same output signal generated by the inductance-to-number convertor using a proper algorithm. The conceived device is meant to be part of the "wear and forget" equipment dedicated to monitoring the vital signs continuously.
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Técnicas Biosensibles , Electrocardiografía/métodos , Corazón/fisiología , Monitoreo Fisiológico , Algoritmos , Frecuencia Cardíaca/fisiología , Humanos , Respiración , Textiles , Dispositivos Electrónicos VestiblesRESUMEN
Customer retention is invariably the top priority of all consumer businesses, and certainly it is one of the most critical challenges as well. Identifying and gaining insights into the most probable cause of churn can save from five to ten times in terms of cost for the company compared with finding new customers. Therefore, this study introduces a full-fledged geodemographic segmentation model, assessing it, testing it, and deriving insights from it. A bank dataset consisting 11,000 instances, which consists of 10,000 instances for training and 10,000 instances for testing, with 14 attributes, has been used, and the likelihood of a person staying with the bank or leaving the bank is computed with the help of logistic regression. Base on the proposed model, insights are drawn and recommendations are provided. Stepwise logistic regression methods, namely, backward elimination method, forward selection method, and bidirectional model are constructed and contrasted to choose the best among them. Future forecasting of the models has been done by using cumulative accuracy profile (CAP) curve analysis.
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Comercio , Comportamiento del Consumidor , Predicción , Aprendizaje Automático , HumanosRESUMEN
In this study, we developed Different Artificial Intelligence (AI) models namely Artificial Neural Network (ANN), Adaptive Network based Fuzzy Inference System (ANFIS) and Support Vector Machine (SVM) for the prediction of Compression Coefficient of soil (Cc) which is one of the most important geotechnical parameters. A Monte Carlo approach was used for the sensitivity analysis of the AI models and input parameters. For the construction and validation of the models, 189 soft clayey soil samples were analyzed. In the models study, 13 input parameters: depth of sample, bulk density, plasticity index, moisture content, clay content, specific gravity, void ratio, liquid limit, dry density, porosity, plastic limit, degree of saturation, and liquidity index were used to obtain one output parameter "Cc". Validation of the models was done using statistical methods such as Mean Absolute Error (MAE), Root Mean Square Error (RMSE), and Coefficient of determination (R2). Results of the model validation indicate that though performance of all the three models is good but SVM model is the best in the prediction of Cc. The Monte Carlo method based sensitivity analysis results show that out of the 13 input parameters considered for the models study, four parameters namely clay, degree of saturation, specific gravity and depth of sample are the most relevant in the prediction of Cc, and other parameters (bulk density, dry density, void ratio and porosity) are the most insignificant parameters for the prediction of Cc. Removal of these insignificant parameters helped to reduce the dimension of the input space and also model running time, and improved significantly the performance of the AI models. The results of this study might help in selecting the suitable AI models and input parameters for better and quick prediction of the Cc of soil.
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Besides physical consequences, obesity has negative psychological effects, thereby lowering human life quality. Major psychological consequences of this disorder includes depression, impaired body image, low self-esteem, eating disorders, stress and poor quality of life, which are correlated with age and gender. Physical interventions, mainly diet control and energy balance, have been widely applied to treat obesity; and some psychological interventions including behavioral therapy, cognitive behavioral therapy and hypnotherapy have showed some effects on obesity treatment. Other psychological therapies, such as relaxation and psychodynamic therapies, are paid less attention. This review aims to update scientific evidence regarding the mental consequences and psychological interventions for obesity.
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Terapia Conductista , Obesidad/terapia , Humanos , Obesidad/psicología , Calidad de VidaRESUMEN
Developmental defects of enamel (DDE) are induced and regulated by several factors including genetics and the environment. There is evidence showing that dioxin in polluted areas has a strong effect on the health and development of teeth. However, there has been no study on DDE in the dioxin-affected regions in Vietnam. To identify the effect of dioxin on the prevalence of DDE in studied areas in Vietnam, a cross-sectional study was conducted in 2200 adults in the A Luoi district in the Thua Thien Hue province (the dioxin-affected region) and in the Kim Bang district in the Ha Nam province (dioxin-unaffected region) in 2015. All subjects were interviewed using a structured questionnaire and their teeth were examined and scored for enamel defects based on the 1992 FDI criteria. The defected teeth were then photographed. Our results showed that the DDE rate in A Luoi was 20.5% when measured as mouth prevalence and 5.8% when measured as tooth prevalence, while the rates in Kim Bang were 10.4 and 2.32% for mouth and tooth prevalence, respectively. Demarcated opacities were predominated in both districts (45.5% in A Luoi and 52.2% in Kim Bang). The DDE rate of the anterior teeth group was higher than that of the posterior teeth group. Most lesions presented on the buccal surface of the tooth. Overall, the DDE prevalence in the dioxin-affected region was 2.2 times higher than that in non-dioxin-affected region in the studied regions in Vietnam.
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Hipoplasia del Esmalte Dental/inducido químicamente , Hipoplasia del Esmalte Dental/epidemiología , Dioxinas/toxicidad , Exposición a Riesgos Ambientales/efectos adversos , Adolescente , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Encuestas y Cuestionarios , Vietnam/epidemiologíaRESUMEN
Disease diagnosis from medical images has become increasingly important in medical science. Abnormality identification in retinal images has become a challenging task in medical science. Effective machine learning and soft computing methods should be used to facilitate Diabetic Retinopathy Diagnosis from Retinal Images. Artificial Neural Networks are widely preferred for Diabetic Retinopathy Diagnosis from Retinal Images. It was observed that the conventional neural networks especially the Hopfield Neural Network (HNN) may be inaccurate due to the weight values are not adjusted in the training process. This paper presents a new Modified Hopfield Neural Network (MHNN) for abnormality classification from human retinal images. It relies on the idea that both weight values and output values can be adjusted simultaneously. The novelty of the proposed method lies in the training algorithm. In conventional method, the weights remain fixed but the weights are changing in the proposed method. Experimental performed on the Lotus Eye Care Hospital containing 540 images collected showed that the proposed MHNN yields an average sensitivity and specificity of 0.99 and accuracy of 99.25%. The proposed MHNN is better than HNN and other neural network approaches for Diabetic Retinopathy Diagnosis from Retinal Images.
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Retinopatía Diabética/diagnóstico , Procesamiento de Imagen Asistido por Computador/métodos , Redes Neurales de la Computación , Anciano , Algoritmos , Retinopatía Diabética/diagnóstico por imagen , Femenino , Humanos , Masculino , Persona de Mediana Edad , Sensibilidad y EspecificidadRESUMEN
Water pollution is the root cause for many diseases in the world. It is necessary to measure water quality using sensors for prevention of water pollution. However, the related works remain the problems of communication, mobility, scalability, and accuracy. In this paper, we propose a new Supervisory Control and Data Acquisition (SCADA) system that integrates with the Internet of Things (IoT) technology for real-time water quality monitoring. It aims to determine the contamination of water, leakage in pipeline, and also automatic measure of parameters (such as temperature sensor, flow sensor, color sensor) in real time using Arduino Atmega 368 using Global System for Mobile Communication (GSM) module. The system is applied in the Tirunelveli Corporation (Metro city of Tamilnadu state, India) for automatic capturing of sensor data (pressure, pH, level, and energy sensors). SCADA system is fine-tuned with additional sensors and reduced cost. The results show that the proposed system outperforms the existing ones and produces better results. SCADA captures the real-time accurate sensor values of flow, temperature, and color and turbidity through the GSM communication.
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Monitoreo del Ambiente/métodos , Internet , Contaminación del Agua/análisis , Calidad del Agua , Abastecimiento de Agua , Agua/química , Ciudades , IndiaRESUMEN
Designing optimization models and meta-heuristic algorithms for minimization of traveling routes of vehicles in solid waste collection has been gaining interest in environmental modeling. The computer models and methods are useful to bring out specific strategies for prevention and precaution of possible disasters that could be foreseen worldwide. This paper proposes a new Spatial Geographic Information System (GIS)-based Genetic Algorithm for optimizing the route of solid waste collection. The proposed algorithm, called SGA, uses a modified version of the original Dijkstra algorithm in GIS to generate optimal solutions for vehicles. Then, a pool of solutions, which are optimal routes of all vehicles, is encoded in Genetic Algorithm. It is iteratively evolved to a better one and finally to the optimal solution. Experiments on the case study at Sfax city in Tunisia are performed to validate the performance of the proposal. It has been shown that the proposed method has better performance than the practical route and the original Dijkstra method.
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Algoritmos , Simulación por Computador , Eliminación de Residuos/métodos , Residuos Sólidos/estadística & datos numéricos , Instalaciones de Eliminación de Residuos , Ciudades , Desastres/prevención & control , Sistemas de Información Geográfica , Vehículos a Motor , TúnezRESUMEN
Overweight and obesity (OW and OB) have been on the increase globally and posed health risks to the world's population of all ages, including pre-born babies, children, adolescents, adults and elderly people, via their comorbid conditions. Excellent examples of comorbidities associated with obesity include cancer, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM). In this article, we aimed to review and update scientific evidence regarding the relationships between obesity and its common physical health consequences, including CVD, T2DM, hypertension, ischemic stroke, cancer, dyslipidemia and reproductive disorders. In addition, the economic burden of OW and OB will be discussed. Abundant evidence is found to support the associations between obesity and other diseases. In general, the odd ratios, risk ratios or hazard ratios are often higher in OW and OB people than in the normal-weight ones. However, the molecular mechanism of how OW and OB induce the development of other diseases has not been fully understood. Figures also showed that obesity and its-related disorders exert enormous pressure on the economy which is projected to increase. This review highlights the fact that obesity can lead to numerous lethal health problems; therefore, it requires a lot of economic resources to fight against this epidemic.