RESUMEN
We demonstrate the iron-catalyzed intermolecular coupling of internal alkynes and thiosalicylic acid derivatives. The reaction was effectively catalyzed by the Fe(acac)2/1,10-phenanthroline catalyst in toluene/HFIP (hexafluoroisopropyl alcohol) as the reaction solvent and afforded several types of 1,3-oxathiine derivatives in moderate to high yields through the intermolecular hydrothiolation and sequential intramolecular cyclization.
RESUMEN
The copper-catalyzed regioselective intermolecular hydroamination of the aryl and trifluoromethyl group or electron-withdrawing group substituted internal alkynes with amines has been accomplished. The reaction was effectively catalyzed by the ligand-free Cu(OTf)2 and afforded the intended amine derivatives in good yields after treatment of NaBH3CN.