Remote Assessment of ADHD Symptoms Based on Mobile Game Performance in Children with ADHD: A Proof of Concept.

The use of game-based digital medicine is gaining increasing interest in helping children with ADHD to improve their attention outside the clinical setting. In this process, it is important to continue monitoring children's responses to the use of digital medicine. In this work, we introduce novel digital markers and an analytic pipeline to estimate ADHD-related symptomatic levels during the self-administration of attention games. The digital markers, capturing the children's characteristics of attention and inattention spans, were extracted and translated into clinically-accepted measures of ADHD symptoms, specifically the ADHD-Rating Scale (ADHD-RS) and Child Behavior Checklist (CBCL). To validate the feasibility of our approach, we collected game-specific performance data from 15 children with ADHD, which was used to train machine learning-based regression models to estimate their corresponding ADHD-RS and CBCL scores. Our experiment results showed mean absolute errors of 5.14 and 4.05 points between the actual and estimated ADHD-RS and CBCL scores respectively. This study enables new clinical and research opportunities for accurate longitudinal assessment of symptomatic levels of ADHD via an interactive means of playing mobile games.

Investigating the Impact of Control Modes to Competency and Engagement in Serious Game Play for Children with ADHD.

Serious games are designed to reduce symptoms of attention deficit among children with Attention Deficit/Hyperactivity Disorder (ADHD). These games predominantly use touchscreen interfaces that children with ADHD play in a sitting position, which contributes to already-problematic sedentary behaviors. In an effort to mitigate negative impacts of sedentary behavior, we set out to investigate the use of Dance Dance Revolution (DDR) mats with serious games to induce gross movements. To that end, we designed and implemented Breathtaking Glass Bridge to investigate the impact of interface (DDR vs. touchscreen) on competency and engagement in children with ADHD. Our investigation with 30 children with ADHD reveal that the DDR mat was as engaging as the conventional touchscreen interface despite relatively lower competence shown by our participants. Our study opens new research opportunities for developing and strategically using movement-based control interfaces to encourage gross movements while reducing attention deficit symptoms among children with ADHD.

Adjuvant Therapy for Attention in Children with ADHD Using Game-Type Digital Therapy.

Children diagnosed with attention deficit hyperactivity disorder (ADHD) require early intervention and sustained treatment. This study used a game-based digital treatment planning NeuroWorld DTx to analyze the impact on attention and cognitive function in children with ADHD. Thirty children diagnosed with ADHD were recruited and subjected to a four-week NeuroWorld DTx digital treatment. To assess the impact of the digital therapeutic therapy on children's attention, we used the comprehension attention test (CAT) and Korean ADHD Rating Scale (K-ARS). Clinical global impression (CGI) and the Korean-child behavior checklist (K-CBCL 6-18) were used to examine the degree of improvement in ADHD. After four weeks, significant differences in the sensitivity and response style indices were noted, as compared with the baseline in the CAT test; in the case of K-ARS and CGI, a moderate decrease in ADHD was confirmed. The study achieved better results for the "total behavior problems" belonging to the K-CBCL assessment. Game-based digital therapy intervention can be a treatment method that elicits interest and satisfaction in children with ADHD and can be used as an adjunct to drug therapy to improve the quality of life and strengthen attention in children with symptoms of ADHD.