RESUMEN
Imbalance was revealed in the proportions of T-lymphocyte subpopulations in those persons engaged in activity in mining employment who had been exposed to a complex of the radiation accident factors. Maximum reduction in the lymphocyte suppressor activity was recordable in those patients in whom the doses of radioactive irradiation received exceeded 25 s Gy. Depression was found of humoral immunity manifested by a drop in the absolute as well as relative numbers of B-lymphocytes and fall in the blood serum levels of Ig G, A. The results of study of clinical-biochemical and immunologic parameters of blood permit individualized therapies be developed, prophylactic measures to be devised to deal with the relevant pathologic processes and conditions in the cohorts examined.
Asunto(s)
Sistema Inmunológico/efectos de la radiación , Exposición Profesional/efectos adversos , Centrales Eléctricas , Liberación de Radiactividad Peligrosa , Adulto , Formación de Anticuerpos/efectos de la radiación , Humanos , Sistema Inmunológico/inmunología , Sistema Inmunológico/fisiología , Inmunidad Celular/efectos de la radiación , Masculino , Persona de Mediana Edad , Minería , Dosis de Radiación , UcraniaRESUMEN
It was established that industrial shops engaged in zinc compounds' processing were characterized by considerable temperature shifts, relative humidity and air motion changes. In drying and packing shops, concentrations of the final product dusts were established at 0.8-2 mg/m3. The major occupational pathology was constituted by skin and upper respiratory tract diseases, including allergic and contact dermatitis, chronic pharyngitis, tonsillitis and rhinitis. Blood tests revealed B-lymphocytes: increases, circulating immune complexes and considerable levels of lymphocytic spontaneous blastotransformations. Erythrocytic acidic hemolysis was markedly changed, which proved disbalances in the system of red blood.