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Our technologically advanced civilization has made sensors an essential component. They have potential uses in the pharmaceutical sector, clinical analysis, food quality control, environmental monitoring, and other areas. One of the most active fields of analytical chemistry research is the fabrication of electrochemical sensors. An intriguing area of electroanalytical chemistry is the modification of electrodes using polymeric films. Due to their benefits, which include high adhesion to the electrode surface, chemical stability of the coating, superior selectivity, sensitivity, and homogeneity in electrochemical deposition, polymer-modified electrodes have attracted a great deal of interest in the electroanalytical sector. Conducting polymers are an important material for sensing devices because of their fascinating features, which include high mechanical flexibility, electrical conductivity, and the capacity to be electrochemically converted between electronically insulating and conducting states. Tannin or lignin nanomaterials can be an inter-linker leading to flexible and functional polymeric networks. There is a continuing demand for fast and simple analytical methods for the determination of many clinically important biomarkers, food additives, environmental pollutants etc. This review in a comprehensive way summarizes and discusses the various metal oxide and sulfide-incorporated tannin and lignin scaffolds using electrochemical sensing and biosensing.
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This study presents the development of organo-bentonites (OBs); a cost-effective drug delivery system holding both sensing and imaging capabilities. The OBs were synthesized using quaternary ammonium cations derived from chitosan, Lawsonia inermis, and pyrene/anthracene carboxaldehyde combinations through a three-step process: Mannich reaction, quaternization, and intercalation. Physicochemical characterization confirms the organic modification of bentonite. The OBs: NQPB and NQAB hold substantial ciprofloxacin (Cipro) loading capacities (71.51 % and 78.04 %, respectively) and exhibit pH-dependent release profiles, suggesting their potential use as drug delivery platforms. Cell viability evaluation by MTT and live-dead assays indicates favourable results. Both OBs demonstrate fluorescence within the 450-500 nm range, and they display concentration-dependent fluorescence quenching and enhancement for NQPB and NQAB, respectively, in the presence of tryptophan (Trp), making them suitable for its detection. Confocal analysis further enunciates the live intracellular fluorescence upon OB uptake. In summary, the intrinsically fluorescent mesoporous OBs synthesized from Lawsonia inermis and chitosan exhibit multifunctionality, including Cipro delivery, Trp sensing, and live cell imaging. Among the OBs, NQAB could be considered as a promising theranostic platform owing to its superior cytocompatibility (>80 %), appreciable fluorescence, and controlled release profile.
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Quitosano , Lawsonia (Planta) , Bentonita/química , Lawsonia (Planta)/química , Arcilla , Nanomedicina Teranóstica , Sistemas de Liberación de Medicamentos , Ciprofloxacina/farmacologíaRESUMEN
OBJECTIVES: Mpox has been declared a Public Health Emergency of International Concern by the World Health Organization on July 23, 2022. Since early May 2022, Mpox has been continuously reported in several endemic countries with alarming death rates. This led to several discussions and deliberations on the Mpox virus among the general public through social media and platforms such as health forums. This study proposes natural language processing techniques such as topic modeling to unearth the general public's perspectives and sentiments on growing Mpox cases worldwide. STUDY DESIGN: This was a detailed qualitative study using natural language processing on the user-generated comments from social media. METHODS: A detailed analysis using topic modeling and sentiment analysis on Reddit comments (n = 289,073) that were posted between June 1 and August 5, 2022, was conducted. While the topic modeling was used to infer major themes related to the health emergency and user concerns, the sentiment analysis was conducted to see how the general public responded to different aspects of the outbreak. RESULTS: The results revealed several interesting and useful themes, such as Mpox symptoms, Mpox transmission, international travel, government interventions, and homophobia from the user-generated contents. The results further confirm that there are many stigmas and fear of the unknown nature of the Mpox virus, which is prevalent in almost all topics and themes unearthed. CONCLUSIONS: Analyzing public discourse and sentiments toward health emergencies and disease outbreaks is highly important. The insights that could be leveraged from the user-generated comments from public forums such as social media may be important for community health intervention programs and infodemiology researchers. The findings from this study effectively analyzed the public perceptions that may enable quantifying the effectiveness of measures imposed by governmental administrations. The themes unearthed may also benefit health policy researchers and decision-makers to make informed and data-driven decisions.
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COVID-19 , Mpox , Medios de Comunicación Sociales , Humanos , COVID-19/epidemiología , Procesamiento de Lenguaje Natural , Mpox/epidemiología , Brotes de Enfermedades , ActitudRESUMEN
Forest fire is considered as one of the major threats to global biodiversity and a significant source of greenhouse gas emissions. Rising temperatures, weather conditions, and topography promote the incidences of fire due to human ignition in South Asia. Because of its synoptic, multi-spectral, and multi-temporal nature, remote sensing data can be a state of art technology for forest fire management. This study focuses on the spatio-temporal patterns of forest fires and identifying hotspots using the novel geospatial technique "emerging hotspot analysis tool" in South Asia. Daily MODIS active fire locations data of 15 years (2003-2017) has been aggregated in order to characterize fire frequency, fire density, and hotspots. A total of 522,348 active fire points have been used to analyze risk of fires across the forest types. Maximum number of forest fires in South Asia was occurring during the January to May. Spatial analysis identified areas of frequent burning and high fire density in South Asian countries. In South Asia, 51% of forest grid cells were affected by fires in 15 years. Highest number of fire incidences was recorded in tropical moist deciduous forest and tropical dry deciduous forest. The emerging hotspots analysis indicates prevalence of sporadic hotspots, followed by historical hotspots, consecutive hotspots, and persistent hotspots in South Asia. Of the seven South Asian countries, Bangladesh has highest emerging hotspot area (34.2%) in forests, followed by 32.2% in India and 29.5% in Nepal. Study results offer critical insights in delineation of fire vulnerable forest landscapes which will stand as a valuable input for strengthening management of fires in South Asia.
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Incendios , Incendios Forestales , Asia , Bangladesh , Monitoreo del Ambiente , Bosques , India , Nepal , ÁrbolesRESUMEN
OBJECTIVE: This study aimed to (i) determine habitual dietary patterns of Malaysian patients on hemodialysis (HD) and (ii) examine their association with nutritional status. METHODS: An à posteriori approach examined 3-day dietary recalls of 382 multiethnic Malaysian patients on HD, leading to short-listing of 31 food groups. Dietary patterns were derived through principal component analysis. Sociodemographic and lifestyle characteristics together with nutritional parameters were examined for associations with specific dietary patterns. RESULTS: Four dietary patterns emerged, namely, "Home Food," "Eating Out (EO)-Rice," "EO-Sugar sweetened beverages," and "EO-Noodle." Younger patients, male gender, Malay, and patients with working status were more likely to follow "EO-Rice" and "EO-Sugar sweetened beverages" patterns, while Chinese patients were more likely to consume "EO-Noodle" pattern (all P values < .05). The EO frequency was directly associated with "EO-Rice" (P = .030), "EO-Sugar sweetened beverages" (P = .040), and "EO-Noodle" (P = .001) patterns. The highest tertile of the "Home Food" pattern related to higher handgrip strength (T3 = 21.3 ± 0.74 vs. 18.0 ± 0.73 kg, P = .006), higher serum albumin (T3 = 3.99 ± 0.04 vs. T1 = 3.84 ± 0.04 g/dL, P = .027), and lower Malnutrition-Inflammation Score (T3 = 4.9 ± 0.36 vs. T1 = 6.4 ± 0.34, P = .010), along with lower Diet Monotony Index (T3 = 29.0 ± 1.1 vs. T1 = 33.0 ± 1.0, P = .030). while "EO-Rice" and "EO-Sugar sweetened beverage" patterns were associated only with higher energy intake (all P values < .001). CONCLUSIONS: These results indicated that a home-based diet inclusive of healthy food choices was associated with better nutritional status in this HD population.
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Dieta/métodos , Estado Nutricional , Diálisis Renal , Estudios Transversales , Femenino , Humanos , Estilo de Vida , Malasia , Masculino , Persona de Mediana Edad , Factores SocioeconómicosRESUMEN
Biosynthetic adaptation of endophytic bacteria to chemically support host plant is very remarkable. Hence these organisms from medicinal plants are considered as highly valuable sources for natural products with diverse bioactivity. Their metabolite diversity and biosynthetic versatility have been increasingly explored for drug discovery. In this study, an endophytic Bacillus mojavensis with broad spectrum antibacterial properties has been analyzed for the chemical basis of its activity. By LC-MS/MS the organism was identified to have the biosynthetic ability to produce lipopeptides surfactin and fengycin. The impressive antibacterial activity of B. mojavensis as reported in the study indicates its broad antimicrobial applications.