RESUMEN
Splenic rupture most commonly follows blunt abdominal trauma. Nontraumatic rupture of the spleen is rare. Nontraumatic rupture of the spleen has been described in a variety of pathologic conditions, which include neoplastic, infectious, and hematologic diseases affecting the spleen. Spontaneous rupture of nondiseased spleen is extremely rare. We report a case of spontaneous rupture of spleen in a chronic alcoholic clinically simulating acute pancreatitis.
Asunto(s)
Rotura del Bazo/diagnóstico , Consumo Excesivo de Bebidas Alcohólicas/complicaciones , Diagnóstico Diferencial , Diagnóstico por Imagen , Resultado Fatal , Humanos , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Pancreatitis/diagnóstico , Rotura EspontáneaRESUMEN
A novel series of quinolinone-based adenosine A(2B) receptor antagonists was identified via high throughput screening of an encoded combinatorial compound collection. Synthesis and assay of a series of analogs highlighted essential structural features of the initial hit. Optimization resulted in an A(2B) antagonist (2i) which exhibited potent activity in a cAMP accumulation assay (5.1 nM) and an IL-8 release assay (0.4 nM).