1.
Zh Nevrol Psikhiatr Im S S Korsakova
; 112(3 Pt 1): 39-43, 2012.
Artículo
en Ruso
| MEDLINE
| ID: mdl-22677754
RESUMEN
We conducted a comparative study on the effect of active compounds of pantogam and pantogam active (calcium D(R)-homopantothenate and calcium DL(RS)-homopantothenate) and its L(S)-isomer on the receptors of main brain neuromediators in rats using in vitro radioligand binding analysis. All three compounds interact with binding sites of specific GABA-A and, in particular, GABA-B receptor ligands. Racemate and S-enantiomer, but not its R-form, competed to a moderate degree for D2-receptor binding sites. In all cases, degrees of interaction with receptors were ranged as follows: S-isomer>racemate>R-isomer. These qualitative and quantitative differences are assumed to contribute to pharmacological activity of both drugs.
Asunto(s)
Encéfalo/efectos de los fármacos , Ácido Pantoténico/análogos & derivados , Receptores de Dopamina D2/metabolismo , Receptores de GABA-A/metabolismo , Receptores de GABA-B/metabolismo , Ácido gamma-Aminobutírico/análogos & derivados , Animales , Encéfalo/metabolismo , Ácido Pantoténico/química , Ácido Pantoténico/farmacocinética , Ácido Pantoténico/farmacología , Ensayo de Unión Radioligante , Ratas , Estereoisomerismo , Ácido gamma-Aminobutírico/química , Ácido gamma-Aminobutírico/farmacocinética , Ácido gamma-Aminobutírico/farmacología
2.
Biokhimiia
; 31(5): 881-6, 1966.
Artículo
en Ruso
| MEDLINE
| ID: mdl-6001324