RESUMEN
BACKGROUND: Clean Cut is an adaptive, multimodal programme to identify improvement opportunities and safety changes in surgery by enhancing outcomes surveillance, closing gaps in surgical infection prevention standards, and strengthening underlying processes of care. Surgical-site infections (SSIs) are common in low-income countries, so this study assessed a simple intervention to improve perioperative infection prevention practices in one. METHODS: Clean Cut was implemented in five hospitals in Ethiopia from August 2016 to October 2018. Compliance data were collected from the operating room focused on six key perioperative infection prevention standards. Process-mapping exercises were employed to understand barriers to compliance and identify locally driven improvement opportunities. Thirty-day outcomes were recorded on patients for whom intraoperative compliance information had been collected. RESULTS: Compliance data were collected from 2213 operations (374 at baseline and 1839 following process improvements) in 2202 patients. Follow-up was completed in 2159 patients (98·0 per cent). At baseline, perioperative teams complied with a mean of only 2·9 of the six critical perioperative infection prevention standards; following process improvement changes, compliance rose to a mean of 4·5 (P < 0·001). The relative risk of surgical infections after Clean Cut implementation was 0·65 (95 per cent c.i. 0·43 to 0·99; P = 0·043). Improved compliance with standards reduced the risk of postoperative infection by 46 per cent (relative risk 0·54, 95 per cent c.i. 0·30 to 0·97, for adherence score 3-6 versus 0-2; P = 0·038). CONCLUSION: The Clean Cut programme improved infection prevention standards to reduce SSI without infrastructure expenses or resource investments.
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Mejoramiento de la Calidad , Infección de la Herida Quirúrgica/prevención & control , Adulto , Lista de Verificación , Países en Desarrollo , Etiopía , Femenino , Humanos , Periodo Intraoperatorio , Masculino , Estudios Prospectivos , Factores de Riesgo , Procedimientos Quirúrgicos Operativos/efectos adversos , Procedimientos Quirúrgicos Operativos/métodos , Procedimientos Quirúrgicos Operativos/normas , Infección de la Herida Quirúrgica/etiología , Resultado del Tratamiento , Adulto JovenRESUMEN
BACKGROUND: Poor surgical lighting represents a major patient safety issue in low-income countries. This study evaluated device performance and undertook field assessment of high-quality headlights in Ethiopia to identify critical attributes that might improve safety and encourage local use. METHODS: Following an open call for submissions (December 2018 to January 2019), medical and technical (non-medical) headlights were identified for controlled specification testing on 14 prespecified parameters related to light quality/intensity, mounting and battery performance, including standardized illuminance measurements over time. The five highest-performing devices (differential illumination, colour rendering, spot size, mounting and battery duration) were distributed to eight Ethiopian surgeons working in resource-constrained facilities. Surgeons evaluated the devices in operating rooms, and in a comparative session rated each headlight in terms of performance and willingness to purchase. RESULTS: Of 25 submissions, eight headlights (6 surgical and 2 technical) met the criteria for full specification testing. Scores ranged from 8 to 12 (of 14), with differential performance in lighting, mounting and battery domains. Only two headlights met the illuminance parameters of more than 35 000 lux during initial testing, and no headlight satisfied all minimum specifications. Of the five headlights evaluated in Ethiopia, daily operation logbooks noted variability in surgeons' opinions of lighting quality (6-92 per cent) and spot size (0-92 per cent). Qualitative interviews also yielded important feedback, including preference for easy transport. Surgeons sought high quality with price sensitivity (using out-of-pocket funds) and identified the least expensive but high-functioning device as their first choice. CONCLUSION: No device satisfied all the predetermined specifications, and large price discrepancies were critical factors leading surgeons' choices. The favoured device is undergoing modification by the manufacturer based on design feedback so an affordable, high-quality surgical headlight crafted specifically for the needs of resource-constrained settings can be used to improve surgical safety.
ANTECEDENTES: Una iluminación quirúrgica deficiente conlleva importantes problemas de seguridad para los pacientes en países de bajos ingresos. En Etiopía, se evaluó el rendimiento y la capacidad de iluminar el campo quirúrgico de varias lámparas de alta calidad para identificar aspectos esenciales que podrían mejorar la seguridad y fomentar su uso local. MÉTODOS: Tras una convocatoria abierta (diciembre de 2018-enero de 2019), se identificaron lamparás médicas y técnicas (no médicas) para realizar un análisis de 14 variables previamente definidas en relación con la calidad/intensidad de la luz, montaje y rendimiento de la batería, además de mediciones estandarizadas de iluminancia a largo plazo. Los cinco dispositivos de mayor rendimiento (iluminación diferencial, reproducción del color, tamaño del foco, montaje y duración de la batería) se distribuyeron entre 8 cirujanos etíopes que trabajaban en instalaciones con recursos limitados. Los cirujanos evaluaron los dispositivos en quirófano y en sesiones comparativas calificaron el rendimiento de cada lámpara y la disposición para su compra. RESULTADOS: De las 25 propuestas presentadas, 8 lámparas (6 quirúrgicas y 2 técnicas) cumplieron los criterios para realizar las pruebas de especificación completas. Las puntuaciones oscilaron entre 8 y 12 (de un total de 14), con diferencias en los ámbitos de iluminación, montaje y batería. Solo 2 lámparas proporcionaron > 35000 lux de iluminancia durante la prueba inicial, y ninguna lámpara cumplió con todas las especificaciones mínimas. De las cinco lámparas evaluadas en Etiopía, hubo una gran variabilidad en las opiniones de los cirujanos anotadas en los registros realizados, tanto sobre la calidad de la iluminación (21-92%), como del tamaño del foco (0-92%). En las entrevistas cualitativas surgieron comentarios importantes como la preferencia por un transporte fácil. Los cirujanos buscaban la mejor calidad al precio más razonable (dado que se utilizaban fondos propios para su adquisición) e identificaron el dispositivo menos costoso pero con alto funcionamiento como primera opción. CONCLUSIÓN: El hecho de que ningún dispositivo satisfizo todas las especificaciones predeterminadas y la gran variabilidad de precios fueron los aspectos esenciales que determinaron la elección de los cirujanos. El dispositivo mejor valorado está siendo modificado por el fabricante en función de los comentarios de diseño, para lograr una lámpara quirúrgica asequible y de alta calidad diseñada específicamente para satisfacer las necesidades de entornos con recursos limitados en la mejora la seguridad quirúrgica.
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Diseño de Equipo , Iluminación/instrumentación , Seguridad del Paciente , Instrumentos Quirúrgicos , Actitud del Personal de Salud , Países en Desarrollo , Etiopía , Humanos , Entrevistas como Asunto , Quirófanos , Investigación Cualitativa , Calidad de la Atención de Salud , CirujanosRESUMEN
Studies of children with stroke indicate remarkable recovery of language after some initial delay. However, complex language abilities as measured by discourse (connected language) may be required to detect the full impact of stroke on subsequent cognitive-linguistic development. This study examined discourse ability in children with stroke as compared with orthopedic controls, age-at-injury, and lesion effects. Discourse between two groups of children was compared [stroke (n = 17) vs orthopedic control (n = 17)]. The stroke group was subdivided into early age at stroke (<1 year) and late age at stroke (>1 year). The discourse samples were analyzed along two dimensions: language and information structure. Results revealed that the stroke group performed at significantly lower levels than the orthopedic control group across discourse measures. The most important finding was a poorer outcome for early age at stroke as compared with later age at stroke. These findings alter the widespread belief of optimistic language outcomes after childhood stroke. Interestingly, no site or size-of-lesion effects, common to adult stroke, were identified. These findings identify poor long-term outcome with early brain insults at stages far removed from the onset of injury. The implication is that childhood stroke management should be revised to provide protracted follow-up and treatment.
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Encéfalo/patología , Trastornos del Desarrollo del Lenguaje/patología , Plasticidad Neuronal , Pruebas Neuropsicológicas/estadística & datos numéricos , Accidente Cerebrovascular/patología , Adolescente , Adulto , Factores de Edad , Niño , Humanos , Trastornos del Desarrollo del Lenguaje/etiología , Modelos Lineales , Plasticidad Neuronal/fisiología , Estadísticas no Paramétricas , Accidente Cerebrovascular/complicacionesAsunto(s)
Accidentes de Tránsito/prevención & control , Automóviles , Seguridad , Airbags , Directorios como Asunto , Humanos , Equipo Infantil , Internet , Teléfono , Estados UnidosRESUMEN
A diagnostic and therapeutic approach is offered to enable the surgeon and restorative dentist to successfully install endosseous implants into the vertically enhanced ridge. The strategy involves the use of diagnostic and surgical templates to aid in the creation of positive osseous architecture followed by the vertical orientation of the endosseous implant(s). This effort provides optimal hard-tissue and soft-tissue form for the creation of the most favorable crown profiles for implant-supported prostheses.
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Aumento de la Cresta Alveolar , Implantación Dental Endoósea/métodos , Pérdida de Hueso Alveolar/diagnóstico , Pérdida de Hueso Alveolar/cirugía , Aumento de la Cresta Alveolar/clasificación , Aumento de la Cresta Alveolar/instrumentación , Humanos , Modelos Anatómicos , Modelos Dentales , Planificación de Atención al Paciente , Grupo de Atención al PacienteRESUMEN
A restorative design is introduced in preference to the implant-supported bar, clip, or ball-type removable prosthesis. It has been necessary to develop an alternative treatment approach to the placement and restoration of implants in the posterior mandible or maxilla. In an examination of the available therapeutic choices and their rationales, this treatment option offers greater function, esthetics, and comfort. Four maxillary and one mandibular arches were reconstructed with anterior implant-supported fixed bridges/splinted restorations and a precision partial denture design posteriorly, using an extracoronal universal ball attachment. These cases have demonstrated minimal maintenance up to 7 years in function.
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Implantes Dentales , Prótesis Dental de Soporte Implantado , Diseño de Dentadura , Dentadura Parcial Fija , Adulto , Pilares Dentales , Ajuste de Precisión de Prótesis , Retención de Dentadura , Dentadura Parcial Removible , Femenino , Estudios de Seguimiento , Humanos , Arcada Parcialmente Edéntula/rehabilitación , Arcada Parcialmente Edéntula/cirugía , Mandíbula/cirugía , Maxilar/cirugía , Periodontitis/rehabilitación , Periodontitis/terapiaRESUMEN
BACKGROUND: We examined the effect on outcome of mild hypothermia (< 36 degrees C) upon intensive care unit (ICU) admission on patient outcome after coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). METHODS: We performed a retrospective database analysis of 5,701 isolated CABG patients requiring CPB, operated upon from January 1995 to June 1997. Patients were classified as either hypo- (< 36 degrees C) or normothermic (> or = 36 degrees C) upon ICU admission. ICU admission bladder core temperature (BCT) versus outcome was evaluated. Outcome measures included mortality, resource utilization (mechanical ventilation time, ICU and hospital length of stay, and postoperative packed red blood cell transfusion), and major morbidity (cardiac, renal, neurologic, or major infection). RESULTS: Overall, patients admitted to the ICU with BCT < 36 degrees C had a significantly greater mortality (p = 0.02), prolonged mechanical ventilation (p = 0.007), packed red blood cell transfusion (p = 0.001), ICU (p = 0.01), and hospital (p = 0.005) length of stay. CONCLUSIONS: BCT of less than 36 degrees C, upon ICU admission, has a significant association with adverse outcome after CABG with CPB. M An __ Tl QA_7_t-0
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Puente de Arteria Coronaria/efectos adversos , Hipotermia/complicaciones , Hipotermia/etiología , Anciano , Femenino , Humanos , Unidades de Cuidados Intensivos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Admisión del Paciente , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Resultado del TratamientoRESUMEN
BACKGROUND: Corticosteroids have been recommended to facilitate rapid recovery after cardiac surgery. We previously reported that dexamethasone given after induction of anesthesia decreases the incidence of postoperative shivering. We performed a post hoc analysis of the data obtained during that study, focusing on secondary outcomes. METHODS: A total of 235 adult patients undergoing elective coronary or valvular heart surgery were randomized to receive dexamethasone 0.6 mg/kg or placebo after induction of anesthesia. Patients who had pharmacologically treated diabetes mellitus, had hypersensitivity to dexamethasone, or were receiving treatment with corticosteroids were excluded. RESULTS: We found that, compared with placebo, patients receiving dexamethasone were more likely to remain tracheally intubated for 6 hours or less (26.4% vs 10.0%, p = 0.020) and had a lower incidence of early postoperative fever (20.2% vs 36.8%, p = 0.009) and new-onset atrial fibrillation during the first 3 days postoperatively (18.9% vs 32.3%, p = 0.027). However, we could not demonstrate a statistical difference in the intensive care unit or hospital length of stay, or in overall morbidity and mortality. The dexamethasone-treated patients were also more likely to have a higher blood glucose on admission to the intensive care unit (186 mg/dL vs 143 mg/dL, p = 0.012). CONCLUSIONS: Dexamethasone facilitates early tracheal extubation and is associated with a lower incidence of early postoperative fever and new-onset atrial fibrillation. Apart from a treatable decreased glucose tolerance, dexamethasone treatment was not shown to affect morbidity or mortality significantly.
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Antiinflamatorios/administración & dosificación , Procedimientos Quirúrgicos Cardíacos , Dexametasona/administración & dosificación , Anestesia , Fibrilación Atrial/prevención & control , Glucemia/análisis , Procedimientos Quirúrgicos Electivos , Femenino , Humanos , Unidades de Cuidados Intensivos , Intubación Intratraqueal , Tiempo de Internación , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/prevención & control , Resultado del TratamientoRESUMEN
BACKGROUND: N-methyl-d-aspartate (NMDA) receptor antagonists are neuroprotective in animal models of cerebral ischemia, but adverse cardiovascular and neurobehavioral effects have precluded their clinical use. The authors present the neuroprotective, anesthetic, and cardiovascular effects of a novel NMDA antagonist, CNS 5161A. METHODS: Lambs, 4.0-6.5 kg, were anesthetized with isoflurane, intubated, and ventilated and had thermodilution catheters placed in the pulmonary artery and 20-g catheters placed in the femoral artery. The minimum alveolar concentration (MAC) of isoflurane was determined using the "bracketing technique." CNS 5161A was given as a bolus and then as an infusion at three doses. Cardiovascular measurements were determined every 15 min. Other lambs (n = 25) were subjected to cardiopulmonary bypass (CPB) with hypothermic circulatory arrest (HCA) for 120 min. Eighteen received CNS 5161A, and seven received saline vehicle. One hour after CPB, brains were perfusion-fixed and removed for in situ hybridization and immunohistochemistry analysis in half of the animals. The other half survived 48 h before their brains were examined for neuronal degeneration. RESULTS: Isoflurane at MAC significantly decreased blood pressure, heart rate, cardiac output, and systemic vascular resistance by 30-48% (n = 16; P < 0.05). CNS 5161A (n = 12) had no significant cardiovascular effects. All concentrations of CNS 5161A caused a significant reduction (21-29%) of the MAC of isoflurane (n = 12; P < 0.05). CNS 5161A, at serum concentrations greater than 25 ng/ml, completely inhibited c-fosmRNA and c-FOS protein expression in hippocampal neurons after 120 min of HCA, attenuated neuronal degeneration, and improved functional outcome by 47% (P < 0.05). CONCLUSIONS: CNS 5161A at neuroprotective concentrations before CPB-HCA significantly reduces the MAC of isoflurane without cardiovascular effects.
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Anestésicos por Inhalación/farmacología , Encéfalo/efectos de los fármacos , Isoflurano/farmacología , N-Metilaspartato/antagonistas & inhibidores , Fármacos Neuroprotectores/farmacología , Anestesia por Inhalación , Animales , Encéfalo/patología , Puente Cardiopulmonar , Paro Cardíaco Inducido , Hemodinámica/efectos de los fármacos , Hibridación in Situ , Fármacos Neuroprotectores/sangre , OvinosAsunto(s)
Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/enfermería , Bradicardia/diagnóstico , Bradicardia/enfermería , Evaluación en Enfermería/métodos , Taquicardia/diagnóstico , Taquicardia/enfermería , Factores de Edad , Arritmias Cardíacas/fisiopatología , Bradicardia/fisiopatología , Niño , Preescolar , Frecuencia Cardíaca , Hemodinámica , Humanos , Lactante , Recién Nacido , Enfermeras Practicantes , Enfermería Pediátrica , Valores de Referencia , Taquicardia/fisiopatologíaAsunto(s)
Anestésicos Locales/efectos adversos , Benzocaína/efectos adversos , Metahemoglobinemia/inducido químicamente , Administración Tópica , Anciano , Anestésicos Locales/administración & dosificación , Benzocaína/administración & dosificación , Broncoscopía , Cuidados Críticos , Femenino , Hernia Hiatal/cirugía , Humanos , Intubación IntratraquealRESUMEN
OBJECTIVE: To determine whether hospital discharge alone represents a good outcome for patients who had prolonged intensive care after cardiac surgery by studying their postdischarge survival and functional outcome. The secondary objective is to estimate the proportion of intensive care unit (ICU) resources used by the long-stay (> or = 10 initial consecutive ICU days) patients and to identify preoperative patient characteristics that are associated with a prolonged ICU stay and hospital and long-term survival. DESIGN: Inception cohort study. SETTING: The Cleveland Clinic Foundation, a tertiary care, academic teaching institution. PATIENTS: Cardiac surgery patients with an initial ICU stay of 10 or more consecutive days. INTERVENTIONS: Data were collected daily during hospitalization on every adult who underwent coronary artery bypass graft and/or valve surgery at one institution in 1993. Discharged patients who spent >10 initial consecutive days in the ICU after surgery were contacted by telephone to determine vital status and functional capacity using the Duke Activity Status Index. Total ICU and total hospital direct costs were obtained for each patient. MEASUREMENTS AND MAIN RESULTS: The primary outcome measurements were ICU length of stay, hospital mortality, after-surgery and postdischarge mortality and functional capacity, and relative resource utilization. Of the 2,618 cardiac surgery patients who met the inclusion criteria, 142 (5.4%) had an initial ICU length of stay of 10 or more consecutive days. Of these, 47 (33.1%) died in the hospital. Ninety-four of the 95 discharged patients were followed up (median follow-up, 30.6 months), and 44 of the 94 (46.8%) died during the follow-up period. The median Duke Activity Status Index for the 50 survivors was 26 out of a possible 58.2. The 142 long-stay patients used 50% of the total ICU days and 48% of the total ICU direct cost for all 2,618 patients. CONCLUSIONS: Many survivors of prolonged intensive care die soon after hospital discharge and many longer term survivors have a poor functional state. Therefore, hospital discharge is an incomplete measure of outcome for these patients, and longer follow-up is more appropriate. The relatively small number of patients who require prolonged intensive care consumes a disproportionate amount of the total ICU and total hospital direct cost.
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Actividades Cotidianas , Puente de Arteria Coronaria/efectos adversos , Puente de Arteria Coronaria/mortalidad , Cuidados Críticos/estadística & datos numéricos , Implantación de Prótesis de Válvulas Cardíacas/efectos adversos , Implantación de Prótesis de Válvulas Cardíacas/mortalidad , Tiempo de Internación/estadística & datos numéricos , Adulto , Puente de Arteria Coronaria/economía , Cuidados Críticos/economía , Costos Directos de Servicios/estadística & datos numéricos , Femenino , Estudios de Seguimiento , Investigación sobre Servicios de Salud , Implantación de Prótesis de Válvulas Cardíacas/economía , Costos de Hospital/estadística & datos numéricos , Mortalidad Hospitalaria , Humanos , Tiempo de Internación/economía , Modelos Logísticos , Masculino , Análisis Multivariante , Ohio , Pronóstico , Modelos de Riesgos Proporcionales , Factores de Riesgo , Índice de Severidad de la Enfermedad , Análisis de Supervivencia , Factores de Tiempo , Resultado del Tratamiento , Función Ventricular IzquierdaAsunto(s)
Dislexia/enfermería , Dislexia/terapia , Ortóptica , Enfermería Pediátrica/métodos , Niño , HumanosRESUMEN
As more Blue Cross/Blue Shield Organizations employ various means to convert to for-profit status, myriad issues arise concerning the proper treatment of assets that were accumulated during the not-for-profit years of such organizations. Moreover, state officials face pressure from all sides to assure that the conversion process is "fair." In the following Article, the author examines the conversion of Blue Cross and Blue Shield of Georgia to demonstrate the various conversion issues that arise under traditional legal principles--as well as the means by which that Blue employed newly enacted legislation to avoid many of the requirements that otherwise would have attended its conversion.
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Planes de Seguros y Protección Cruz Azul/legislación & jurisprudencia , Organizaciones sin Fines de Lucro/legislación & jurisprudencia , Planes de Seguros y Protección Cruz Azul/economía , Planes de Seguros y Protección Cruz Azul/organización & administración , Organizaciones de Beneficencia/legislación & jurisprudencia , Participación de la Comunidad , Georgia , Consejo Directivo , Propiedad/legislación & jurisprudencia , Planes Estatales de Salud/legislación & jurisprudencia , Exención de Impuesto/legislación & jurisprudencia , Estados UnidosAsunto(s)
Neoplasias Cutáneas/prevención & control , Quemadura Solar/prevención & control , Protectores Solares , Niño , Educación en Salud/métodos , Humanos , Servicios de Información , Internet , Enfermeras Practicantes , Enfermería Pediátrica , Examen Físico , Neoplasias Cutáneas/etiología , Quemadura Solar/complicacionesRESUMEN
Haemolysin is one type of virulence factor that assists in the pathogenesis of Escherichia coli. Currently, hemolytic activity in E. coli has been attributed to haemolysin genes found in either uropathogenic or enterohemorrhagic E. coli. Both haemolysins are classified as RTX toxins because they both have repeats in toxin domains and share similar operon organization, sequence homology, and mechanisms of action. Haemolytic avian E. coli isolates, however, lack either E. coli haemolysin gene. To investigate the avian E. coli haemolysin, a genomic library was made from an avian pathogenic E. coli. A haemolytic clone that was isolated was shown to contain homology with sheA, an E. coli K- 12 gene which causes haemolysis when present in high copy number. The cloned haemolysin gene, hlyE, lacked the conserved amino acid sequence and accessory genes common to all RTX toxins. DNA hybridizations and polymerase chain reaction amplifications showed that the nucleotide sequences homologous to hlyE were not present in a collection of three O157: H7 E. coli, five haemolytic canine uropathogenic E. coli, one haemolytic O26 E. coli, and three haemolytic avian pathogenic E. coli. Thus we have identified a new E. coli haemolysin distinct from the RTX haemolysins and have shown that some avian pathogenic E. coli possess a haemolysin with no apparent homology to hlyE or RTX haemolysins.
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Infecciones por Escherichia coli/microbiología , Infecciones por Escherichia coli/veterinaria , Escherichia coli/genética , Proteínas Hemolisinas/genética , Enfermedades de las Aves de Corral/microbiología , Secuencia de Aminoácidos , Animales , Proteínas Bacterianas , Secuencia de Bases , Pollos , Clonación Molecular , Cartilla de ADN , Enfermedades de los Perros/microbiología , Perros , Escherichia coli/aislamiento & purificación , Proteínas Hemolisinas/química , Proteínas Hemolisinas/aislamiento & purificación , Humanos , Datos de Secuencia Molecular , Reacción en Cadena de la Polimerasa , Alineación de Secuencia , Homología de Secuencia de Aminoácido , Homología de Secuencia de Ácido Nucleico , Porcinos , Enfermedades de los Porcinos/microbiologíaAsunto(s)
Maloclusión/diagnóstico , Maloclusión/terapia , Evaluación en Enfermería/métodos , Adolescente , Niño , Humanos , Maloclusión/clasificación , Maloclusión/complicaciones , Maloclusión/fisiopatología , Enfermeras Practicantes , Aparatos Ortodóncicos , Enfermería Pediátrica , Factores de RiesgoRESUMEN
UNLABELLED: Shivering after cardiac surgery is common, and may be a result of intraoperative hypothermia. Another possible etiology is fever and chills secondary to activation of the inflammatory response and release of cytokines by cardiopulmonary bypass. Dexamethasone decreases the gradient between core and skin temperature and modifies the inflammatory response. The goal of this study was to determine whether dexamethasone can reduce the incidence of shivering. Two hundred thirty-six patients scheduled for elective coronary and/or valvular surgery were randomly assigned to receive either dexamethasone 0.6 mg/kg or placebo after the induction of anesthesia. All patients received standard monitoring and anesthetic management. After arrival in the intensive care unit (ICU), nurses unaware of the treatment groups recorded visible shivering, as well as skin and pulmonary artery temperatures. Analysis of shivering rates was performed by using chi2 tests and logistic regression analysis. Compared with placebo, dexamethasone decreased the incidence of shivering (33.0% vs 13.1%; P = 0.001). It was an independent predictor of reduced incidence of shivering and was also associated with a higher skin temperature on ICU admission and a lower central temperature in the early postoperative period. IMPLICATIONS: Dexamethasone is effective in decreasing the incidence of shivering. The effectiveness of dexamethasone is independent of temperature and duration of cardiopulmonary bypass. Shivering after cardiac surgery may be part of the febrile response that occurs after release of cytokines during cardiopulmonary bypass.