RESUMEN
A 1-year-old German shepherd × husky cross dog was diagnosed with multiple liver abscesses and severe cholangitis secondary to the liver fluke Metorchis conjunctus. The dog was successfully treated with 2 percutaneous transhepatic drainage and alcoholization procedures, and a prolonged course of antibiotics and praziquantel.
Abcès hépatiques multiples chez un chien secondaire à une douve du foieMetorchis conjunctustraitée par drainage transhépatique percutané et alcoolisation. Un chien de race croisée Berger allemand et Husky âgé de 1 an a été diagnostiqué avec des abcès hépatiques multiples et une cholangite grave secondaire à la douve du foie Metorchis conjunctus. Le chien a été traité avec succès à l'aide de deux interventions de drainage transhépatique percutané et d'alcoolisation ainsi que d'un traitement prolongé aux antibiotiques et au praziquantel.(Traduit par Isabelle Vallières).
Asunto(s)
Colangitis/veterinaria , Enfermedades de los Perros/parasitología , Drenaje/veterinaria , Etanol/uso terapéutico , Absceso Hepático/veterinaria , Opisthorchidae , Infecciones por Trematodos/veterinaria , Animales , Colangitis/complicaciones , Colangitis/diagnóstico por imagen , Colangitis/terapia , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/terapia , Perros , Absceso Hepático/diagnóstico por imagen , Absceso Hepático/etiología , Absceso Hepático/terapia , Masculino , Tomografía Computarizada de Emisión/veterinaria , Infecciones por Trematodos/complicaciones , Infecciones por Trematodos/diagnóstico por imagen , Infecciones por Trematodos/terapiaRESUMEN
Flexor tendinitis is a common and debilitating injury of elite and recreational athletes. Healing may be improved through intratendinous injection of insulin-like growth factor-I (IGF-I), which has been shown in vitro to stimulate mitogenesis and enhance tendon matrix production. This study investigated the effects of intratendinous injection of IGF-I on tendon healing in an equine model of flexor tendinitis. Collagenase-induced lesions were created in the tensile region of theflexor digitorum superficialis tendon of both forelimbs of eight horses. Treated tendons were injected with 2 microg rhlGF-I intralesionally every other day for 10 injections, while controls received 0.9% NaCl. Tendon fiber deposition and organization were evaluated serially using ultrasonography throughout the 8 week trial period. Following euthanasia, the tendons were harvested and DNA, hydroxyproline, and glycosaminoglycan content determined, mechanical strength and stiffness evaluated, gene expression and spatial arrangement of collagen types I and III assessed by northern blot and in situ hybridization, and tendon fiber architecture assessed by polarized light microscopy. Local soft tissue swelling was reduced in the IGF-I treated limbs. Similarly, lesion size in IGF-I treated tendons was smaller 3 and 4 weeks after initiation of treatment. Cell proliferation and collagen content of the IGF-I treated tendons were increased compared to controls. Mechanically, IGF-I treated tendons showed a trend toward increased stiffness compared to saline treated controls. Considered together with the decreased soft tissue swelling and improved sonographic healing, these data support the potential use of intralesional IGF-I for treatment of debilitating tendon injuries.