RESUMEN
In the spring of 1766 a black supervisor in Curaçao was the victim of attempted poisoning by a black practitioner or curador, engaged by two persons caught stealing by the supervisor. Data on the case were preserved in a letter from the Curaçao director to the managers of the West-Indian Company in Amsterdam. In retrospect, the symptoms of the intoxication indicate that a similar mixture of toxic plants was used as described in 890 A.D. by the Arabic medical writer Wahshiya in his 'Book of Poisons': Calotropis procera and Pithecellobium unguis cati.
Asunto(s)
Intoxicación por Plantas/historia , Historia del Siglo XVIII , Humanos , Látex/historia , Látex/toxicidad , Masculino , Antillas Holandesas , Plantas Tóxicas/envenenamiento , Venenos/historiaRESUMEN
A 31-year-old pregnant Creole woman with sickle-cell anaemia went through a crisis of acute cholecystitis at 29 weeks' amenorrhoea. The crisis subsided after cholecystectomy, at which relative reduction of the number of sickle-cells by blood transfusions, adequate oxygenation, fluid, and antibiotic prophylaxis were provided. After 35 weeks' amenorrhoea, a healthy son was delivered by caesarean section. After the delivery, she developed fever and abdominal aches with a wound infection, and 10 days later a generalized epileptic attack. She recovered without sequelae. Pregnancy in a woman with sickle-cell anaemia may induce a sickle-cell crisis. The maternal morbidity and mortality and perinatal mortality are high, in spite of a pronounced decrease due to improved care.
Asunto(s)
Anemia de Células Falciformes/complicaciones , Colecistitis/etiología , Complicaciones Hematológicas del Embarazo , Adulto , Cesárea/métodos , Colecistectomía , Colecistitis/cirugía , Epilepsia/etiología , Femenino , Humanos , Embarazo , Complicaciones Hematológicas del Embarazo/terapia , Trastornos Puerperales/etiología , Resultado del TratamientoRESUMEN
OBJECTIVE: To compare ondansetron and domperidone for treatment of delayed nausea/vomiting (DN/V) following highly emetogenic chemotherapy, after attaining total suppression of emesis on the day of chemotherapy by mean of ondansetron (combined with dexamethasone in the case of cisplatin-treated patients). METHODS: Domperidone (3 x 20 mg daily) was compared with ondansetron (3 x 8 mg daily) in a randomized double-bind placebo-controlled study. Out of 65 consecutive patients who received a first course of either cyclophosphamide and cisplatin for advanced stage ovarian cancer or cyclophosphamide, doxorubicin and 5-fluoro-uracil for metastatic breast carcinoma, 60 patients were eligible for entering the study. According to data from the literature these chemotherapeutic regimens with induce DN/V to a comparable degree. The patients were questioned daily from day 2 through day 5 by the same investigator and the severity of nausea or vomiting was scored on a numerical scale. RESULTS: Emesis was totally suppressed in all patients on the day of chemotherapy. As to DN/V, 16 out of 20 patients receiving placebo required "rescue" medication versus none in the other two groups (p < 0.001). Only 2 (10%) patients were symptomatic with domperidone versus 9 (45%) symptomatic patients in the ondansetron-treated group (p < 0.05). CONCLUSIONS: Both drugs are effective, but domperidone (3 x 20 mg) is more effective than ondansetron (3 x 8 mg) for the prevention of the delayed nausea and/or vomiting which occur after highly emetogenic chemotherapy (p < 0.05).
Asunto(s)
Domperidona/uso terapéutico , Náusea/prevención & control , Neoplasias/tratamiento farmacológico , Ondansetrón/uso terapéutico , Vómitos/prevención & control , Adulto , Anciano , Distribución de Chi-Cuadrado , Cisplatino/efectos adversos , Método Doble Ciego , Femenino , Humanos , Persona de Mediana Edad , Náusea/inducido químicamente , Vómitos/inducido químicamenteRESUMEN
Increased plasma levels of prothrombin fragment 1 + 2 (F1 + 2) found in patients with sickle-cell disease reflect enhanced endogenous thrombin generation. We postulate that hypercoagulability contributes to vaso-occlusion. The intensity of acenocoumarol treatment required to reduce the F1 + 2 level to 50% of pretreatment level was investigated in seven patients with symptomatic sickle-cell anaemia during steady-state disease for a period of 2 months. All patients had increased levels of F1 + 2 compared with an age-matched control group. Normalization of the F1 + 2 was achieved at a median INR of 1.64 (range 1.18-2.2). It is concluded that low-intensity oral anticoagulation normalizes the hypercoagulability in sickle-cell disease.
Asunto(s)
Acenocumarol/administración & dosificación , Enfermedad de la Hemoglobina SC/tratamiento farmacológico , Trombina/metabolismo , Administración Oral , Adulto , Femenino , Enfermedad de la Hemoglobina SC/sangre , Humanos , Masculino , Fragmentos de Péptidos/metabolismo , Precursores de Proteínas/metabolismo , Protrombina/metabolismoRESUMEN
The case history is described of a 21-year-old female with homozygous sickle cell disease and fatal postpartum haemorrhage from the colon. At autopsy many sickled cells were found in the arterioles of the mucosa and submucosa in combination with necrotic lesions and ulcerations of the sigmoid colon. A causal association between occlusion of blood vessels by sickled cells and the occurrence of vascular necrosis of the sigmoid colon is suspected.
Asunto(s)
Anemia de Células Falciformes/complicaciones , Colitis/etiología , Hemorragia Gastrointestinal/etiología , Hemorragia Posparto/etiología , Complicaciones Hematológicas del Embarazo , Enfermedad Aguda , Adulto , Femenino , Humanos , Necrosis , EmbarazoRESUMEN
A 35-year-old negroid patient, known to have sickle cell-haemoglobin C disease, after heavy exercise developed an acute thrombotic crisis localised mainly in the brain. The clinical manifestations were those of an acute psychosis with severe confusion, aggressiveness, unco-operative behaviour and incontinence for faeces and urine. With adequate therapy he recovered after a few days. This so-called cerebral sickle cell crisis, confirmed by multiple small encephalomalacia lesions on the MRI which are typical of this disease, is a rare complication and difficult to diagnose.
Asunto(s)
Anemia de Células Falciformes/complicaciones , Enfermedad de la Hemoglobina C/complicaciones , Trastornos Neurocognitivos/etiología , Enfermedad Aguda , Adulto , Encéfalo/patología , Humanos , Imagen por Resonancia Magnética , Masculino , Trastornos Neurocognitivos/patologíaAsunto(s)
Anemia Hipocrómica/complicaciones , Trastornos de Deglución/complicaciones , Síndrome de Plummer-Vinson/etiología , Anemia Hipocrómica/tratamiento farmacológico , Trastornos de Deglución/terapia , Femenino , Humanos , Síndrome de Plummer-Vinson/complicaciones , Síndrome de Plummer-Vinson/terapiaRESUMEN
At oesophagogastroscopy a web was seen in the upper oesophagus in a female of 73 years with dysphagia. Because she also had a smooth tongue, a low serum iron level and anaemia, the syndrome of Plummer-Vinson was diagnosed. After treatment with ferrous fumarate the dysphagia, the web and the anaemia disappeared and the serum iron rose. The symptomatology of this syndrome is discussed. Remarkably, the pathogenesis is not completely known. There are indications that this uncommon syndrome is a premalignant disorder.
Asunto(s)
Anemia Hipocrómica/complicaciones , Síndrome de Plummer-Vinson/complicaciones , Anciano , Anemia Hipocrómica/tratamiento farmacológico , Endoscopía Gastrointestinal , Femenino , Compuestos Ferrosos/uso terapéutico , Humanos , Síndrome de Plummer-Vinson/diagnóstico , Lesiones Precancerosas/patologíaRESUMEN
Five patients with sickle cell disease have been studied by magnetic resonance imaging (MRI) in three instances during a crisis. Attention was directed to the pelvis and lower extremities. Bone marrow pathology has been classified according to generalised or circumscribed alterations in signal intensity on T1 weighted spin-echo sequences. Both acute and chronic changes were observed.
Asunto(s)
Anemia de Células Falciformes/diagnóstico , Médula Ósea/patología , Adulto , Anciano , Femenino , Humanos , Imagen por Resonancia Magnética , MasculinoRESUMEN
Two patients admitted after ingestion of 80% acetic acid are described. Only the first patient developed haemolysis, slight intravascular coagulation and oliguric kidney insufficiency. They were treated with a nasogastric tube and total parenteral feeding. During the first week after admission urinary excretion of beta 2-microglobulin, alanine-aminopeptidase and N-acetyl-glucosaminidase was significantly increased. The patients remained haemodynamically stable and did not develop fever. The above-mentioned elevated excretions returned to normal levels. Both patients showed similar patterns of tubular proteinuria. The observations in the second patient suggest a direct toxic effect of acetic acid on the proximal tubule of the kidney.
Asunto(s)
Acetatos/envenenamiento , Lesión Renal Aguda/inducido químicamente , Túbulos Renales/efectos de los fármacos , Ácido Acético , Acetilglucosaminidasa/orina , Adolescente , Adulto , Aminopeptidasas/orina , Antígenos CD13 , Esofagitis/inducido químicamente , Femenino , Gastritis/inducido químicamente , Hemólisis/efectos de los fármacos , Humanos , Masculino , Microglobulina beta-2/orinaRESUMEN
Pycnodysostosis is a rare sclerosing bone disorder in which osteomyelitis of the jaws is a frequent complication. Treatment of osteomyelitis of the jaws in pycnodysostosis is difficult and may lead to large resections. A review of the literature and 3 new cases in which osteomyelitis was successfully treated by a combined surgical and antibiotic approach, are reported.