[Generalised, symmetric muscle weakness in survivors after intensive therapy].

ICU-acquired weakness (ICUAW) is often found in critically ill patients and is characterised by a generalised, symmetric weakness, affecting limb (proximal more than distal) and respiratory muscles. It is a diagnosis of exclusion. ICUAW is associated with increased morbidity and mortality, and decreased quality of life. The aetiology is not completely understood, and there is no established treatment or prevention yet. The most important risk factors are high disease severity, multiorgan failure, systemic inflammation and prolonged immobilisation. Individual needs for rehabilitation must be defined, as argued in this review.

[IgG4-related disease is a rare differential diagnosis of malignant and autoimmune diseases]. / Immunglobulin G4-relateret sygdom er en sjælden differentialdiagnose til maligne og autoimmune sygdomme

Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory and fibrotic disease with the potential to produce diffuse enlargement, massforming lesions or stenoses in a wide range of organs. Elevation of serum IgG4 concentration and high levels of IgG4-positive cells in the inflamed tissue are common denominators. Type 1 autoimmune pancreatitis is one of the main manifestations, and its recognition preceded the definition of IgG4-RD as a novel clinical entity. The aetiology, pathophysiology, epidemiology and clinical long-term outcome of IgG4-RD are not fully elucidated. Steroids are effective in most patients, sometimes combined with other antiinflammatory drugs.