The impact of injuries on sports-related analgesic use in Danish youth elite athletes: A 4-week prospective cohort study.

OBJECTIVES: Investigate the association between injury severity and sports-related analgesic use, and explore the types and reasons for analgesic use in Danish youth elite athletes. DESIGN: 4-week prospective cohort study. METHODS: 713 youth elite athletes (44 % female) aged 15-20 years provided information on demographics, sports specific questions, and injury severity. We categorized injury severity based on the amount of impact on sports participation: 1) no injury (reference), 2) injury not affecting sports participation, 3) injury causing modifications in sports participation, and 4) injury causing complete absence from sport. Participants were asked weekly over 4 weeks about the number of days with sports-related analgesic use, types, and reasons for use. Mixed-effects regression models were used to assess the association between injury severity and prevalence (yes/no) and frequency (days/week) of analgesic use. RESULTS: Analgesic use at least once during the four weeks was reported by 224 athletes (31 %), with a mean weekly prevalence of 13 %. The odds of analgesic use increased with injury severity compared with the reference group; injury not affecting sports participation: OR 2.6 (95 % CI 1.6-4.2), injury causing modifications in sports participation: OR 3.2 (95 % CI 2.0-5.2), injury causing complete absence from sport: OR 3.6 (95 % CI 1.5-8.7) (test for trend; p = <0.001). The rate (frequency) of analgesic use also increased with injury severity (test for trend; p = 0.003). Athletes most commonly used analgesics to treat pain/injury after sports participation (62 %), and paracetamol was most frequently used (84 %). CONCLUSIONS: Injury severity was associated with increased odds and rate of analgesic use.

Popping Pills in Youth Elite Sports-Fact or Fiction? A 36-Week Prospective Cohort Study of Analgesic Use in 1195 Youth Elite Athletes and Student Controls.

OBJECTIVE: To investigate analgesic use in a cohort of Danish youth elite athletes and compare weekly analgesic use over 36 weeks to student controls. We also investigated and compared reasons for analgesic use and types of analgesics used. DESIGN: Prospective cohort study. METHODS: Six hundred ninety youth elite athletes (44% females) and 505 student controls (59% females) (aged 15-20 years) provided weekly reports on analgesic use over 36 weeks. We asked about the number of days with analgesic use, reasons for use, and types of analgesics used. Prevalence and frequency of analgesic use was compared between youth elite athletes and student controls using mixed-effects logistic regression and mixed-effects Poisson regression models. Reasons for and types of analgesics used were compared between groups using chi-square tests. Subgroup analyses were performed, stratified by sex. RESULTS: Overall, athletes had lower odds of analgesic use (odds ratio = 0.78; 95% confidence interval [CI], 0.64 to 0.95) compared with student controls. The overall usage rate was similar between the groups (incidence rate ratio = 1.04; 95% CI, 0.99 to 1.11). Subgroup analyses suggested no statistically significant differences in the odds of analgesic use. Significantly more athletes reported using analgesics to prevent or treat pain or injury in relation to sports participation and to use topical gels compared with student controls. CONCLUSION: Participating in youth elite sports was associated with lower odds of analgesic use compared to student controls, but usage rate was similar between the groups. Reasons for use and types of analgesics used differed between athletes and student controls. J Orthop Sports Phys Ther 2024;54(8):551-559. Epub 9 May 2024. doi:10.2519/jospt.2024.12407.

To rest or to compete? A 4-week cohort study of analgesic use and willingness to compete hurt in Danish youth elite athletes.

OBJECTIVES: To assess the association between analgesic use and willingness to compete hurt (WCH) in Danish youth elite athletes, and to explore factors associated with such willingness. DESIGN: 4-week prospective cohort study. METHODS: 592 Danish youth elite athletes (15-20 years) completed a baseline questionnaire assessing demographic information, sport history, and WCH, and provided weekly reports on analgesic use for 4 weeks via text messages. Analgesic use was categorized as no use (0 weeks) or use across 1, 2, 3, or 4 weeks, and as the total number of days with analgesic use. Multinomial logistic regression and zero-inflated negative binomial regression analyses estimated the association between analgesic use and WCH. Linear backward stepwise regression analysis was used to identify factors associated with WCH. RESULTS: Overall, risk of analgesic use increased significantly with increasing WCH scores (relative risk ratios ranging from 1.06 (95% CI 1.0 to 1.12%) to 1.34% (95% CI 1.15 to 1.57)). The incidence rate of analgesic use increased significantly with increasing WCH scores (incidence rate ratio 1.09 (95% CI 1.04 to 1.14)). Associations between the investigated possible antecedent factors and WCH were weak and not considered practically important (R2 = 0.05 or lower). CONCLUSIONS: Higher WCH scores were associated with increasing risk of analgesic use, irrespective of the underlying reason for the use, in Danish youth elite athletes, suggesting that analgesics may be an ingrained part of a sport-specific culture of risk acceptance. Future studies should include measures of culture, norms, and social interaction to better explain the variance in WCH.

Prevalence, frequency, adverse events, and reasons for analgesic use in youth athletes: A systematic review and meta-analysis of 44,381 athletes.

OBJECTIVES: To identify the prevalence, frequency, adverse effects, and reasons for analgesic use in youth athletes. DESIGN: Systematic review and meta-analysis. METHODS: Systematic searches in Embase, Medline, and SPORT-Discus from inception to September 2021, screening of reference lists, and citation tracking were performed to identify observational studies including athletes aged 15-24 years and reporting data on prevalence and/or frequency of analgesic use. Study quality was assessed using the Newcastle-Ottawa Scale. Random-effect proportion meta-analyses, stratified by type of analgesic medication and prevalence measure, estimated the prevalence of analgesic use. Data on usage frequency, adverse events, and reasons for analgesic use was synthesized narratively. RESULTS: Forty-nine studies were included (44,381 athletes), of which 19 were good/high quality. Seven categories of analgesics were identified across 10 prevalence time-points. Meta-analyses suggested common use of NSAIDs (point prevalence 48 % [95 % CI 23 % to 73 %], in-season prevalence 92 % [95 % CI 88 % to 95 %]). The lowest prevalence was found for use of local anesthetic injections within the previous 12 months (2 % [95 % CI 1 % to 3 %]). Seven to 50 % of athletes reported weekly analgesics use. The proportion of adverse events ranged from 3.3 % to 19.2 %. Reasons for using analgesics included treatment of sports-related pain or injury, to treat illness, and to enhance performance. CONCLUSIONS: Analgesics are commonly used in youth athletes, but estimates vary depending on type of analgesic and prevalence measure. As the majority of studies were of poor methodological quality, future high-quality research should include prospective data collection of analgesic use to understand consumption trajectories.