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Elife ; 82019 12 11.
Artículo en Inglés | MEDLINE | ID: mdl-31825307

RESUMEN

Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the availability of tools to share and disseminate data is scarce. Automated touchscreen-based tests enable systematic cognitive assessment with easily standardised outputs that can facilitate data dissemination. Here we present an integration of touchscreen cognitive testing with an open-access database public repository (mousebytes.ca), as well as a Web platform for knowledge dissemination (https://touchscreencognition.org). We complement these resources with the largest dataset of age-dependent high-level cognitive assessment of mouse models of Alzheimer's disease, expanding knowledge of affected cognitive domains from male and female mice of three strains. We envision that these new platforms will enhance sharing of protocols, data availability and transparency, allowing meta-analysis and reuse of mouse cognitive data to increase the replicability/reproducibility of datasets.


Asunto(s)
Cognición/fisiología , Ciencia de los Animales de Laboratorio/instrumentación , Ciencia de los Animales de Laboratorio/métodos , Roedores , Enfermedad de Alzheimer , Animales , Conducta Animal , Conducta de Elección , Bases de Datos Factuales , Modelos Animales de Enfermedad , Femenino , Aprendizaje/fisiología , Masculino , Memoria/fisiología , Ratones , Pruebas Neuropsicológicas , Reproducibilidad de los Resultados , Roedores/genética , Programas Informáticos
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