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1.
J Strength Cond Res ; 2024 Aug 14.
Artículo en Inglés | MEDLINE | ID: mdl-39178053

RESUMEN

ABSTRACT: Vasileiou, SS, Asimakidis, ND, Dalamitros, AA, and Manou, V. Effects of an 8-week in-season explosive power training program on neuromuscular performance and lower limb asymmetries in young male soccer players. J Strength Cond Res XX(X): 000-000, 2024-This study analyzed the effects of incorporating 8 weeks of twice-weekly explosive power training on neuromuscular performance and lower-limb asymmetries applied to soccer. Thirty-five young male soccer players were randomly assigned to either the experimental group (EXP: n = 18; mean age: 13.7 ± 0.8 years; height: 166.9 ± 8.4 cm; body mass: 58.5 ± 12.8 kg) or the control group (CON: n = 17; mean age: 13.7 ± 0.9 years; height: 168.8 ± 9.1 cm; body mass: 58.0 ± 11.4 kg). Before (TP1) and after the training period (TP2) neuromuscular performance (countermovement jump [CMJ], 10 and 20 m sprint times [T10 and T20], change of direction ability [COD]) and lower-limb asymmetries (single-leg CMJ [SLCMJ]) were evaluated. The asymmetry index (AI) for COD and CMJ tests was also calculated. Significant differences (from TP1 to TP2) were revealed for all the tested parameters in the EXP group (1.50-4.9%, p < 0.00 to 0.12, effect size [ES] = -0.44 to 0.27). For the CON group, T10, T20 505 for nondominant limb and SLCMJ performances for both limbs were significantly improved (0.85 to 1.5%, p < 0.00 to 0.21, ES = -0.36 to 0.37). Finally, the AI remained relatively unchanged for both tests and groups (1.28-3.33%, p = 0.162-0.521). These results indicate that adding twice-weekly explosive power training for 8 weeks can improve neuromuscular performance and reduce lower-limb asymmetries to a greater degree than soccer training alone in young male soccer players.

2.
Artículo en Inglés | MEDLINE | ID: mdl-35564333

RESUMEN

The COVID-19 outbreak has led to an unprecedented long-term cessation in athletes' training routines. This study examined the effect of a 32-week detraining period, caused by the COVID-19 pandemic lockdown, on selected neuromuscular performance indicators in 29 young male soccer players, assessed close to their adolescent growth spurt (age = 13.0 ± 0.8 years). Change of direction ability of both lower limbs (COD), linear sprint times (10 and 20 m), and vertical jump height (CMJ) was evaluated twice, once before the first national lockdown, and one week after the return to training activities. Paired-sample t-tests detected significant improvements in all three testing variables (COD: 2.82 ± 0.23 vs. 2.66 ± 0.22 s, p ≤ 0.005, 0.001, effect size [ES] = 0.91 to 1.05 for the right and left limb, respectively; 10 m: 2.12 ± 0.16 vs. 1.96 ± 0.15 s, p ≤ 0.001, effect size [ES] = 1.67, 20 m: 3.56 ± 0.3 vs. 3.42 ± 0.27 s, p ≤ 0.001, effect size [ES] = 1.02 and CMJ: 23.3 ± 7.5 vs. 24.5 ± 7.6 cm, p = 0.033, ES = 0.42). These results indicate that maturation-related adaptations can lead to enhanced change of direction, linear sprint, and vertical jump performance, even in the absence of exposure to any level of exercise. Soccer coaches and practitioners working with youth athletes should consider the stage of maturation when planning and implementing training programs aiming to enhance neuromuscular performance.


Asunto(s)
Rendimiento Atlético , COVID-19 , Fútbol , Adolescente , COVID-19/epidemiología , Niño , Control de Enfermedades Transmisibles , Humanos , Masculino , Pandemias
3.
Int J Mol Sci ; 23(3)2022 Jan 31.
Artículo en Inglés | MEDLINE | ID: mdl-35163571

RESUMEN

The Papanicolaou Society of Cytopathology (PSC) reporting system classifies pancreatobiliary samples into six categories (I-VI), providing guidance for personalized management. As the World Health Organization (WHO) has been preparing an updated reporting system for pancreatobiliary cytopathology, this systematic review aimed to evaluate the risk of malignancy (ROM) of each PSC category, also the sensitivity and specificity of pancreatic FNA cytology using the current PSC system. Five databases were investigated with a predefined search algorithm. Inclusion and exclusion criteria were applied to select the eligible studies for subsequent data extraction. A study quality assessment was also performed. Eight studies were included in the qualitative analysis. The ROM of the PSC categories I, II, III, IV, V, VI were in the ranges of 8-50%, 0-40%, 28-100%, 0-31%, 82-100%, and 97-100%, respectively. Notably, the ROM IVB ("neoplastic-benign") subcategory showed a 0% ROM. Four of the included studies reported separately the ROMs for the IVO subcategory ("neoplastic-other"; its overall ROM ranged from 0 to 34%) with low (LGA) and high-grade atypia (HGA). ROM for LGA ranged from 4.3 to 19%, whereas ROM for HGA from 64 to 95.2%. When the subcategory IVO with HGA was considered as cytologically positive, together with the categories V and VI, there was a higher sensitivity of pancreatic cytology, at minimal expense of the specificity. Evidence suggests the proposed WHO international system changes-shifting the IVB entities into the "benign/negative for malignancy" category and establishing two new categories, the "pancreatic neoplasm, low-risk/grade" and "pancreatic neoplasm, high-risk/grade"-could stratify pancreatic neoplasms more effectively than the current PSC system.


Asunto(s)
Citodiagnóstico , Páncreas/patología , Neoplasias Pancreáticas/patología , Sociedades Médicas , Humanos , Clasificación del Tumor , Medición de Riesgo , Organización Mundial de la Salud
4.
Eur J Contracept Reprod Health Care ; 27(1): 53-60, 2022 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-34615425

RESUMEN

OBJECTIVE: The objective of this research was to evaluate how menstrual tracking applications can promote gynaecological health. MATERIALS AND METHODS: We performed a systematic review in Medline and Scopus, for papers evaluating menstrual tracking mobile applications. We excluded review articles and those not written in English. RESULTS: We identified 14 articles measuring the outcome resulting from the use of a single Fertility Tracking Application (FTA). Eight studies evaluated 2 different applications used as a contraception method. One study assessed a fecundity enhancing application. Five studies referred to applications, used to treat or monitor various gynaecologic issues. All studies reported efficacy for their intended use or a high satisfaction rate. DISCUSSION: There is a plethora of FTAs, however a minority of them are appraised by medical experts. Several safety and privacy concerns have been expressed regarding their use and these issues should be addressed in the future. All studies identified in our search demonstrated that FTAs can facilitate users in terms of contraception, fertility, and menstrual awareness. CONCLUSION: Menstrual tracking applications can serve as a valuable health tool, nevertheless, their content should be more vigorously evaluated.


Asunto(s)
Aplicaciones Móviles , Telemedicina , Fertilidad , Humanos , Menstruación
5.
J Neonatal Perinatal Med ; 15(1): 105-111, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-34459416

RESUMEN

BACKGROUND: A congenital lung malformation (CLM) that is diagnosed on prenatal ultrasound exam may subsequently become undetectable on later scans, a "vanishing" CLM. OBJECTIVE: The purpose of our study is to characterize the prenatal natural history and postnatal outcomes of "vanishing" lesions treated at our institution. METHODS: We performed a retrospective chart review of 107 patients diagnosed prenatally with CLM at our institution. Comparisons were made using Kruskal-Wallis or t-test for continuous variables and Fisher's exact test or Chi-Square test for categorical variables. Multivariable analysis using logistic regression was performed. RESULTS: Of the 104 patients, 59 (56.7%) had lesions that became sonographically undetectable on serial ultrasound scans. Patients with lesions that vanished prenatally tended to need less Neonatal Intensive Care Unit (NICU) admission at birth (persistent CLM: 54.8%vs vanished CLM: 28.8%), decreased need for supplemental O2 at birth (persistent CLM: 31.0%vs vanished CLM: 11.9%), and decreased delay in feeds (persistent CLM: 26.2%vs vanished CLM: 8.5%) compared to those with persistent CLM. After multivariate analysis controlling for maternal steroid administration and sex, admission to NICU maintained a slight statistical significance, with patients in the vanishing CLM group 2.5 times less likely to be admitted to the NICU. None of our patients whose lesions vanished prenatally required mechanical ventilation. Eighty-six patients underwent postnatal computed tomography (CT) chest. Only 2 patients had lesions that regressed on postnatal CT. CONCLUSION: Lesions that vanish on prenatal imaging may be associated with improved clinical outcomes. The rate of true regression at our institution was as low as 2.3%.


Asunto(s)
Pulmón , Anomalías del Sistema Respiratorio , Femenino , Humanos , Incidencia , Recién Nacido , Pulmón/diagnóstico por imagen , Embarazo , Estudios Retrospectivos , Ultrasonografía Prenatal
6.
Phys Chem Chem Phys ; 23(26): 14352-14362, 2021 Jul 07.
Artículo en Inglés | MEDLINE | ID: mdl-34169950

RESUMEN

Films of polar molecules vapour-deposited on sufficiently cold substrates are not only amorphous, but also exhibit charge polarization across their thickness. This is an effect known for 50 years, but it is very poorly understood and no mechanism exists in the literature that can explain and predict it. We investigated this bulk effect for 18 small organic molecules as a function of substrate temperature (30-130 K). We found that, as a rule, alcohol films have the negative end on the vacuum side at all temperatures. Alkyl acetates and toluene showed positive voltages which reached a maximum around the middle of the temperature range investigated. Tetrahydrofuran showed positive voltages which dropped with increasing deposition temperature. Diethyl ether, acetone, propanal, and butanal showed positive film voltages at low temperatures, negative at intermediate temperatures and again positive voltages at higher temperatures. In all cases, film voltages were monitored during heating leading to film evaporation. Film voltages were irreversibly eliminated before film elimination, but voltage profiles during temperature ramps differed vastly depending on compound and deposition temperature. In general, there was a gradual voltage reduction, but propanal, butanal, and diethyl ether showed a change in voltage sign during temperature ramp in films deposited at low temperatures. All these data expand substantially the experimental information regarding spontaneous polarization in vapour-deposited films, but still require complementary measurements as well as numerical simulations for a detailed explanation of the phenomenon.

7.
EFORT Open Rev ; 4(4): 143-150, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31057951

RESUMEN

Reconstruction of the central band of the interosseous membrane is an emerging procedure implemented in the treatment of longitudinal radioulnar dissociation (LRUD), usually in its chronic setting, after Essex-Lopresti injuries of the forearm.There are no sufficient clinical data to support reconstruction of the central band of the interosseous membrane in acute LRUD injuries.Clinical and cadaveric studies comparing autografts (palmaris longus, flexor carpi radialis and bone-patellar-bone), allografts (Achilles tendon) and synthetic ligaments have not shown superiority of one technique versus another; however, they have shown special concerns with respect to the use of synthetic grafts.Latrogenic fracture, decrease of rotational range of movement, iatrogenic nerve injury (superficial radial and median nerve), donor site morbidity with autografts and recurrent instability are the complications reported in literature after interosseous membrane reconstruction. Cite this article: EFORT Open Rev 2019;4:143-150. DOI: 10.1302/2058-5241.4.180072.

9.
Hellenic J Cardiol ; 50(1): 26-36, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19196618

RESUMEN

INTRODUCTION: The aim of this study was to determine whether sex and biochemical markers of inflammation have a role in left ventricular (LV) remodelling after aortic valve replacement in elderly patients with aortic valve stenosis. METHODS: We studied 52 elderly patients with aortic valve stenosis (32 men, mean age 65 +/- 11 years and 20 women, mean age 68 +/- 9 years). Body surface area did not differ between men and women (1.81 +/- 0.15 versus 1.84 +/- 0.20, respectively). All patients underwent a complete echocardiographic examination for the determination of ejection fraction (EF), LV mass and mass index, peak and mean systolic pressure gradient, aortic valve area, early (E) and late (A) transmitral flow wave velocities and their ratio (E/A), tissue Doppler indexes of the mitral annulus (Sa, Ea, Aa), and the E/Ea ratio. In addition, levels of high sensitivity C-reactive protein (hsCRP), tumour necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) were measured from venous blood samples taken before, and 10 days, 3 months and 6 months after aortic valve replacement. RESULTS: LV mass decreased from 297 +/- 99.7 g before aortic valve replacement to 210 +/- 67 g 3 months after surgery and to 210 +/- 74 g 6 months after surgery (p<0.001). LV EF did not change significantly (p=0.836). Peak and mean systolic pressure gradients decreased, whereas aortic valve area increased after valve replacement (p<0.001). These changes were similar in men and women. In women Sa was greater (p=0.017) and the E/Ea ratio lower (p=0.025) than in men. The long-term changes in peak and mean pressure gradients, aortic valve area and LV mass after aortic valve replacement were well correlated with the long-term changes in hsCRP, TNF-alpha and MCP-1 in both men and women. CONCLUSIONS: LV remodelling is similar in elderly men and women with aortic valve disease who have similar body surface area. Although inflammatory markers are not correlated with echocardiographic parameters before aortic valve replacement, a strong correlation exists after operation. This correlation is similar in men and women.


Asunto(s)
Estenosis de la Válvula Aórtica/complicaciones , Estenosis de la Válvula Aórtica/cirugía , Proteína C-Reactiva/metabolismo , Quimiocina CCL2/sangre , Factor de Necrosis Tumoral alfa/sangre , Remodelación Ventricular/fisiología , Anciano , Estenosis de la Válvula Aórtica/sangre , Biomarcadores/sangre , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Factores Sexuales , Factores de Tiempo , Resultado del Tratamiento
10.
Hellenic J Cardiol ; 48(1): 5-14, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17388104

RESUMEN

INTRODUCTION: Patients with aortic valve stenosis show elevated levels of inflammatory markers in peripheral blood. The aim of this study was to investigate the time course of changes in these markers and to look for sex-related changes in their biological behaviour following aortic valve replacement. METHODS: We studied 52 patients (32 men, 20 women) who underwent aortic valve replacement and had no concomitant coronary artery disease. Men and women did not differ significantly with respect to age, body surface area, or body mass index. Levels of high sensitivity C-reactive protein (hsCRP), tumour necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) were measured from venous blood samples taken before, and 10 days, 3 months and 6 months after aortic valve replacement. RESULTS: Baseline hsCRP levels were 5.34 +/- 5.71 mg/dl and 7.64 +/- 7.46 mg/dl for men and women, respectively. Levels increased significantly at 10 d (49.11 +/- 32.15 and 51.63 +/- 34.3 mg/dl, p < 0.001), then reduced at 3 m (5.85 +/- 5.04 and 8.49 +/- 7.69 mg/dl, p < 0.001) and 6 m (3.41 +/- 0.83 and 7.84 +/- 7.32 mg/dl, p < 0.001). Women had higher levels than men at 6 m (p = 0.027). Levels of TNF-alpha reduced progressively, from 212.4 +/- 119.5 and 255.7 +/- 171.3 pg/ml at baseline, to 121.6 +/- 47.7 and 150.0 +/- 33.5 pg/ml at 10 d, 134.7 +/- 25.3 and 138.6 +/- 30.9 at 3 m, and 48.7 +/- 8.8 and 44.9 +/- 10.5 pg/ml at 6 m (p < 0.001). MCP-1 levels also reduced progressively, from 157 +/- 64.8 and 145.6 +/- 13.4 pg/ml at baseline, to 128.6 +/- 18.8 and 122.7 +/- 10.3 pg/ml at 10 d, 49.0 +/- 12.4 and 56.6 +/- 11.5 pg/ml at 3 m, and 29.1 +/- 6.4 and 30.6 +/- 7.3 pg/ml at 6 m (p < 0.001). The time course of the changes in these indexes was identical for men and women, except that 6 m hsCRP levels were significantly higher in women. CONCLUSIONS: After aortic valve replacement, hsCRP levels show an early increase followed by a decrease, whereas both TNF-alpha and MCP-1 are reduced progressively. The time course curve is identical in men and women, except that hsCRP levels are higher in women than in men 6 months after aortic valve replacement.


Asunto(s)
Estenosis de la Válvula Aórtica/sangre , Estenosis de la Válvula Aórtica/cirugía , Proteína C-Reactiva/análisis , Quimiocina CCL2/sangre , Factor de Necrosis Tumoral alfa/sangre , Anciano , Femenino , Implantación de Prótesis de Válvulas Cardíacas , Humanos , Masculino , Persona de Mediana Edad , Periodo Posoperatorio , Factores Sexuales , Factores de Tiempo
11.
J Pediatr Surg ; 36(11): 1725-7, 2001 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-11685713

RESUMEN

PURPOSE: This study evaluates the multistaged extrathoracic esophageal elongation procedure performed on 12 babies with long gap esophageal atresia over 15 years. METHODS: Eight babies had pure esophageal atresia, 2 had proximal tracheoesophageal fistula (TEF), and 2 had distal TEF. The gaps ranged between 2 and 7 vertebral bodies. Proximal esophagostomy, TEF ligation, and gastrostomy were performed initially. The proximal esophagus is elongated 2 to 3 cm each time by translocating the esophagostomy distally along the anterior chest wall at 2- to 3-month intervals. Sham-fed milk is collected in an ostomy bag and refed via the gastrostomy. The definitive esophageal reconstruction is performed at 5 to 24 months of age. RESULTS: Only one elongation was required in 4 babies, 2 were needed in 5, 3 in 2, and 5 in 1 patient. All patients tolerated sham feeding well. After esophageal restoration, 3 patients had minor leakage. All (12 of 12) patients had anastomotic stenosis requiring multiple dilatations, of which, 3 needed resection of stricture. Eleven patients had gastroesophageal reflux that required fundoplication. Follow-up was possible in 11 patients for 4 months to 14 years after esophageal restoration. Seven early patients are eating normally. CONCLUSION: Multistaged extrathoracic esophageal elongation is effective in stretching the proximal esophagus to bridge 2 to 7 vertebral bodies.


Asunto(s)
Atresia Esofágica/cirugía , Esófago/cirugía , Fístula Traqueoesofágica/cirugía , Preescolar , Esofagostomía , Femenino , Gastrostomía , Humanos , Lactante , Masculino , Reoperación
12.
Semin Pediatr Surg ; 10(1): 20-2, 2001 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-11172567

RESUMEN

Operative repair of visceral injuries in children is infrequent enough so that an individual surgeon's experience may decay as time goes by. This report recommends incisions, a plan for thorough exploration, and the best surgical strategies for abdominal injuries, Simplicity and organ conservation are emphasized.


Asunto(s)
Traumatismos Abdominales/cirugía , Niño , Diafragma/lesiones , Diafragma/cirugía , Humanos , Intestinos/lesiones , Intestinos/cirugía , Hígado/lesiones , Hígado/cirugía , Páncreas/lesiones , Páncreas/cirugía , Bazo/lesiones , Bazo/cirugía , Estómago/lesiones , Estómago/cirugía
14.
J Pediatr Surg ; 35(2): 164-7; discussion 167-9, 2000 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-10693659

RESUMEN

PURPOSE: This study is intended to resolve the disparity and reach consensus on issues regarding the treatment of children with isolated spleen or liver injuries. To maximize patient safety and assure efficient, cost-effective utilization of resources, it was essential to determine current practice. METHODS: Data from the case records of 856 children with isolated spleen or liver injury treated at 32 pediatric surgical centers from July 1995 to June 1997 were collected. The severity of injury was classified by computed tomography (CT) grade and the data analyzed for intensive care unit (ICU) stay, length of hospital stay, transfusion requirement, need for operation, pre- and postdischarge imaging, and restriction of physical activity. Patients with grade V injuries (2.8%) were excluded leaving 832 patients for detailed review. These data and available literature were analyzed for consensus by the 1998 APSA Trauma Committee. RESULTS: Resource utilization increased with injury severity (see Table 2). Based on the data analysis, literature search, and consensus conference, the authors propose guidelines (see Table 3) for the safe and optimal utilization of resources in routine cases. It is important to emphasize that no recommendation falls outside the 25th percentile of current practice at participating centers. CONCLUSIONS: Diversity of treatment, with attendant variation in resource utilization in children with isolated spleen and liver injury of comparable severity is confirmed. This analysis has stimulated a prospective outcomes study with the objective of validating the evidence-based guidelines proposed. This evidence-based study design can bring order and conformity to patient management resulting in optimal utilization of resources while maximizing patient safety.


Asunto(s)
Hígado/lesiones , Bazo/lesiones , Adolescente , Niño , Preescolar , Medicina Basada en la Evidencia , Femenino , Hospitalización , Humanos , Lactante , Puntaje de Gravedad del Traumatismo , Hígado/diagnóstico por imagen , Masculino , Guías de Práctica Clínica como Asunto , Pautas de la Práctica en Medicina , Bazo/diagnóstico por imagen , Deportes , Tomografía Computarizada por Rayos X/estadística & datos numéricos
16.
Pediatr Radiol ; 29(7): 497-502, 1999 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-10398782

RESUMEN

BACKGROUND: Prognosis in neuroblastoma has been shown to correlate with age and stage at diagnosis and site of origin. Extra-abdominal tumors (chest, neck, pelvis) do better in terms of survival than tumors arising from the upper abdomen. OBJECTIVE: We evaluated a subgroup of abdominal neuroblastomas arising near to the aortic bifurcation (commonly called organ of Zuckerkandl, O. Z.) to assess their biologic outcome and problems in diagnosis and therapy. MATERIALS AND METHODS: Sixteen O. Z. primary tumors were seen at three children's hospitals. Their clinical records and imaging studies were reviewed, including the sonographic, CT, and MRI findings. When available, MYCN amplification was noted (MYCN is the current term previously called N-MYC). RESULTS: Despite more than half of the tumors being very large, survival was the rule, with only one fatality (following multiple local recurrences). Only one patient (who survived) had bone metastases. The larger masses were usually palpated in otherwise well children, while the smaller ones were found in the course of evaluation for unrelated problems such as urinary tract infection. Intraspinal extension was common, though usually asymptomatic. MYCN amplification was absent in the four patients studied. CONCLUSIONS: Lower abdominal (O. Z.) neuroblastomas present technical problems of surgical removal, but form a group with a favorable outcome similar to cervical and thoracic primary sites. MRI was useful in delineating intraspinal extension.


Asunto(s)
Neoplasias Abdominales/patología , Aorta Abdominal/patología , Neuroblastoma/patología , Neoplasias Abdominales/diagnóstico por imagen , Aorta Abdominal/diagnóstico por imagen , Neoplasias Óseas/secundario , Niño , Preescolar , Humanos , Lactante , Recién Nacido , Imagen por Resonancia Magnética , Invasividad Neoplásica , Neuroblastoma/diagnóstico por imagen , Neuroblastoma/secundario , Pronóstico , Tomografía Computarizada por Rayos X , Ultrasonografía
17.
J Pediatr Surg ; 34(5): 908-12; discussion 912-3, 1999 May.
Artículo en Inglés | MEDLINE | ID: mdl-10359204

RESUMEN

BACKGROUND/PURPOSE: The current medical environment demands the provision of quality healthcare at an affordable cost. Both payors and regulators are committed to lowering cost through initiation of best practice strategies that include practice guidelines, clinical pathways, and standards of care. The only practical way to join this debate is through the use of objective, unbiased clinical data. This study was undertaken to review the current state of the pediatric surgery literature and its value in determining best clinical practice. METHODS: The National Library of Medicine Medline database was accessed using the Ovid Internet client software. All references, abstracts, and keyword indexes from the core pediatric surgery literature, the Journal of Pediatric Surgery, the European Journal of Pediatric Surgery, Pediatric Surgery International, Zeitschrift fur Kinderchirurgie, and Seminars in Pediatric Surgery were downloaded and reviewed. Search criteria were defined to identify prospective, randomized, controlled studies. References were then categorized as case reports; retrospective case series; prospective case series; randomized, controlled studies; laboratory studies; review articles; or miscellaneous studies. RESULTS: As of March 1, 1998, there are 9,373 references, excluding citations of letters or comments, contained in the core pediatric surgery literature, as provided through Medline. Of these, 485 were identified as studies for review, possible prospective case series or prospective, randomized, controlled studies. After review, 34 studies (0.3%) were classified as prospective, randomized, controlled studies, whereas 139 (1.48%) were classified as prospective studies. There were 3,241 (34.6%) case reports, 5,619 (59.9%) retrospective case series, 1,109 (11.8%) laboratory studies, 195 (2.1%) review articles, and 36 (0.3%) miscellaneous studies that did not fit into other categories. When analyzed by decade of publication, prospective studies and prospective, randomized, controlled studies (n = 173) numbered 103 in the 1990s, 63 in the 1980s, and seven in the 1970s. CONCLUSIONS: There is a paucity of scientifically rigorous data on which to base clinical practice in pediatric surgery. The increasing numbers of prospective, case-controlled studies or the more sound prospective, randomized, controlled trials in the 1990s suggests that pediatric surgeons are aware of the need to generate unbiased data to support current clinical practice and the development of practice guidelines. Limitations exist in conducting prospective, randomized, controlled trials because of the rare nature of many pediatric surgical conditions and the lack of clinical "equipoise" over available treatment options. The authors encourage the use of multiinstitutional trials and the prospective, randomized, controlled study methodology to develop data that can be used to guide clinical practice in our evolving healthcare environment.


Asunto(s)
Pediatría , Publicaciones Periódicas como Asunto , Medicina Basada en la Evidencia , Humanos , MEDLINE , Publicaciones Periódicas como Asunto/estadística & datos numéricos , Ensayos Clínicos Controlados Aleatorios como Asunto , Proyectos de Investigación
18.
Pediatr Clin North Am ; 45(4): 853-9, 1998 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-9728190

RESUMEN

Traumatic injuries represent the most important threat to the health of children in the United States and are the leading cause of death after the first year of life. More than 20,000 children and young adults will die this year as a result of injury. For every child that dies, another 40 will require hospitalization and 1000 more will be evaluated in emergency departments. Moreover, 50,000 children and adolescents will sustain some degree of permanent disability, the majority of victims of brain injury. This article focuses on several important long-term implications for children, their families and primary care physicians, following multisystem injuries.


Asunto(s)
Traumatismo Múltiple/complicaciones , Traumatismos Abdominales/epidemiología , Traumatismos Abdominales/rehabilitación , Accidentes de Tránsito , Adolescente , Adulto , Factores de Edad , Lesiones Encefálicas/diagnóstico , Lesiones Encefálicas/epidemiología , Lesiones Encefálicas/rehabilitación , Niño , Preescolar , Enfermedad Crónica , Femenino , Humanos , Masculino , Traumatismo Múltiple/diagnóstico , Traumatismo Múltiple/epidemiología , Traumatismo Múltiple/rehabilitación , Cinturones de Seguridad , Factores de Tiempo
19.
Curr Opin Pediatr ; 10(3): 323-7, 1998 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-9716898

RESUMEN

Laparoscopy has been shown to be a safe and effective method to establish or rule out a diagnosis in difficult clinical situations and, in selected cases, provide minimally invasive access for therapeutic procedures. Relevant indications for diagnostic laparoscopy in the pediatric population include evaluation of a contralateral patent processus vaginalis in a child with a known unilateral inguinal hernia, an impalpable testis, acute and chronic abdominal pain, staging in cancer, and evaluation of traumatic injuries. Selected articles concerning these and other uses of diagnostic laparoscopy published between December 1996 and November 1997 are the subject of this review.


Asunto(s)
Laparoscopía/métodos , Traumatismos Abdominales/diagnóstico , Dolor Abdominal/diagnóstico , Niño , Criptorquidismo/diagnóstico , Hernia/diagnóstico , Humanos , Masculino , Estadificación de Neoplasias/métodos , Selección de Paciente
20.
J Pediatr Surg ; 33(2): 339-42, 1998 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-9498413

RESUMEN

BACKGROUND: Diffuse abdominal or retroperitoneal hemorrhage is potentially lethal particularly when associated with coagulopathy, hypothermia, and acidosis. Temporary abdominal packing (PACKS) can control hemorrhage and provide crucial time to correct these physiological and metabolic derangements. METHODS: The author reviewed the combined experience of pediatric surgeons at 13 institutions to determine the efficacy of this technique. RESULTS: Twenty-two patients with refractory hemorrhage (ages, 6 days to 20 years) were treated with PACKS. The etiology of hemorrhage was trauma in 13, solid organ tumor bed in four, liver bleeding during necrotizing enterocolitis surgery in two, hemorrhagic pancreatitis in one, iliac artery injury while on extracorporeal membrane oxygenation (ECMO) in one, and biliary reconstruction after liver transplant in one. The anatomic site of hemorrhage was the liver or hepatic veins in 14, retroperitoneum or pelvis in seven, and the pancreatic bed in one. Twenty patients (91%) were coagulopathic, hypothermic, and acidotic at the time of packing. Fifteen patients (68%) had PACKS inserted during a primary operative procedure, whereas seven patients (32%) had PACKS inserted during a reexploration for persistent hemorrhage. The mean volume of intraoperative transfusion before PACKS was 190 mL/kg (range, 50 to 600). Primary fascial closure was accomplished in 12 (55%) patients, and temporary skin closure or prosthetic material was used in the other ten. PACKS controlled hemorrhage in 21 of 22 (95%) patients. Removal of PACKS was possible within 72 hours in 18 (82%) patients. No patient experienced rebleeding after PACKS removal; however, two patients died with PACKS in place. An abdominal abscess developed in seven patients (32%); all were successfully drained. Eighteen patients (82%) survived after abdominal packing. Two deaths were caused by multisystem organ failure, one was caused by cardiac failure from uncorrectable cardiac anomalies, and one was from exsanguination after blunt traumatic liver injury. There were no differences in volume of intraoperative blood product transfusion, time to initiate PACKS, physiological status, or type of abdominal closure between survivors and nonsurvivors. CONCLUSION: The author concludes that temporary abdominal packing can be life saving in children with refractory abdominal or retroperitoneal hemorrhage associated with coagulopathy, hypothermia, and acidosis.


Asunto(s)
Hemorragia Gastrointestinal/terapia , Técnicas Hemostáticas , Adolescente , Adulto , Niño , Preescolar , Hemorragia Gastrointestinal/etiología , Humanos , Lactante , Recién Nacido , Neoplasias/complicaciones , Espacio Retroperitoneal , Estudios Retrospectivos , Heridas y Lesiones/complicaciones
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