Asunto(s)
Carcinoma Basocelular/tratamiento farmacológico , Citocinas/sangre , Mediadores de Inflamación/sangre , Terapia por Láser , Fotoquimioterapia , Neoplasias Cutáneas/tratamiento farmacológico , Anciano , Anciano de 80 o más Años , Ácido Aminolevulínico/administración & dosificación , Ácido Aminolevulínico/uso terapéutico , Carcinoma Basocelular/inmunología , Carcinoma Basocelular/metabolismo , Carcinoma Basocelular/cirugía , Terapia Combinada , Citocinas/biosíntesis , Femenino , Humanos , Inflamación , Inyecciones Intralesiones , Masculino , Neoplasias Cutáneas/inmunología , Neoplasias Cutáneas/metabolismo , Neoplasias Cutáneas/cirugíaRESUMEN
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory skin disease with multiple treatment options that have been used with mixed results. OBJECTIVES: To evaluate the effectiveness, safety and tolerability of intralesional photodynamic therapy (I-PDT) in the management of HS. Also, to assess the effect of this technique on the different areas treated. METHODS: Case series of 38 HS patients treated with I-PDT between 2011-2015 following a standardized protocol to assess response at the treated areas RESULTS: 29 patients achieved a complete response, while persistence was noted on 8 cases and only 1 suffered a recurrence. Difference between basal (median 28.5) and final (0) Hidradenitis Severity Score showed a significant reduction of 24.5 points (p<0.001, 95% OR 19.5-31). Basal (median 10) and final (1) Dermatology Life Quality Index scores reached a reduction of 10 points (p<0.001, 95%OR 8-12). Complete response was achieved in 68.2% of armpits, 88.5% of groins, 88.9% of buttocks and 100% of other locations. 18 out of 38 patients needed only a session to achieve a complete response, while maintaining a good tolerability. CONCLUSION: We believe that I-PDT might be an alternative treatment option for localized HS lesions, achieving a high rate of remission with an adequate maintenance of response i and few complications.
Asunto(s)
Ácido Aminolevulínico/uso terapéutico , Hidradenitis Supurativa/tratamiento farmacológico , Fotoquimioterapia/métodos , Fármacos Fotosensibilizantes/uso terapéutico , Adulto , Ácido Aminolevulínico/administración & dosificación , Femenino , Humanos , Inyecciones Intralesiones , Rayos Láser , Masculino , Fotoquimioterapia/efectos adversos , Fotoquimioterapia/instrumentación , Fármacos Fotosensibilizantes/administración & dosificación , Estudios Prospectivos , Recurrencia , Índice de Severidad de la Enfermedad , Resultado del TratamientoAsunto(s)
Ácido Aminolevulínico/administración & dosificación , Carcinoma Basocelular/tratamiento farmacológico , Recurrencia Local de Neoplasia , Fotoquimioterapia , Fármacos Fotosensibilizantes/administración & dosificación , Neoplasias Cutáneas/tratamiento farmacológico , Supervivencia sin Enfermedad , Estudios de Seguimiento , Humanos , Inyecciones Intralesiones , Recurrencia Local de Neoplasia/prevención & control , Factores de TiempoRESUMEN
Photodynamic therapy is a common treatment in dermatology for several diseases, its main limitation is the penetration of topical photosensitizer and light in the tissue. However intralesional photodynamic therapy is a new technique where the photosensitizer and sometimes a 630nm laser beam are applied inside the lesión, so it allows achieve deeper penetration. It has been used to treat basal cell carcinoma, hidradenitis suppurativa or keloids.
