RESUMEN
It is known that benzodiazepines have a hypotensive effect, but the mechanism has not been well elucidated yet. To clarify whether this effect is due to central or peripheral mechanism, we administered 5 mg of diazepam or saline intravenously to healthy volunteers and assessed the change in blood pressure, heart rate, muscle sympathetic nerve activity and heart rate variability. After diazepam administration, systolic and mean blood pressure decreased significantly. Muscle sympathetic nerve activity was also significantly reduced but heart rate did not change, whereas the variables of spectral analysis of heart rate variability did not show significant change. We concluded that the hypotensive effect of diazepam in human is mainly due to the central mechanism.
Asunto(s)
Presión Sanguínea/efectos de los fármacos , Sistema Nervioso Central/efectos de los fármacos , Diazepam/farmacología , Hipotensión/inducido químicamente , Músculo Esquelético/inervación , Fibras Simpáticas Posganglionares/efectos de los fármacos , Potenciales de Acción/efectos de los fármacos , Potenciales de Acción/fisiología , Adulto , Presión Sanguínea/fisiología , Sistema Nervioso Central/fisiología , Estudios Cruzados , Frecuencia Cardíaca/efectos de los fármacos , Frecuencia Cardíaca/fisiología , Humanos , Hipotensión/fisiopatología , Masculino , Músculo Esquelético/fisiología , Fibras Simpáticas Posganglionares/fisiologíaRESUMEN
Yoku-kan-san-ka-chimpi-hange (YKCH) is a drug used for insomnia in Japanese traditional herbal medicine. The present study evaluated the effects of YKCH on sleep by all-night polysomnography using the double-blind method. Yoku-kan-san-ka-chimpi-hange increased the total sleep time significantly, and tended to cause an increase in sleep efficiency and of stage 2 sleep, as well as a decrease of sleep latency and of stage 3 + 4 sleep. There was no apparent influence on rapid eye movement (REM) sleep. In terms of non-REM sleep, the effects of YKCH exhibit a profile similar to those of benzodiazepines.
Asunto(s)
Medicamentos Herbarios Chinos , Medicina Tradicional de Asia Oriental , Polisomnografía/efectos de los fármacos , Fases del Sueño/efectos de los fármacos , Adulto , Benzodiazepinas/administración & dosificación , Estudios Cruzados , Método Doble Ciego , Humanos , Masculino , Sueño/efectos de los fármacosRESUMEN
Donepezil (Aricept) is a therapeutic drug for the treatment of Alzheimer's disease (AD). However, there have been only two reports describing the effects of donepezil on sleep as assessed by nocturnal polysomnography (PSG). With this in mind, the effects of donepezil on the sleep of healthy subjects was evaluated using PSG. The results indicated that the percentage of rapid eye movement sleep to total sleep time was increased significantly by a single dose of 5 mg of donepezil when given to healthy subjects immediately before retiring to bed.
