1.
Org Biomol Chem
; 20(29): 5764-5770, 2022 07 27.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35815554
RESUMEN
An efficient domino approach to assemble benzoxazoles and anthranilamides bearing dithiocarbamate moieties has been developed. The proposed route represents a Cu-catalyzed three-component reaction between readily available 5-iodo-1,2,3-triazoles, amines, and CS2. The cascade transformation is based on a denitrogenative coupling of in situ formed dithiocarbamic acids with diazo intermediates, generated via annulation-triggered triazole ring-opening. This method is applicable to nucleophilic secondary amines and features good functional group compatibility.