A new configuration of lateral-pin fixation for pediatric supracondylar humeral fracture: A biomechanical analysis.

OBJECTIVE: The aim of this study was to biomechanically compare a new lateral-pinning technique, in which pins engage the medial and lateral columns of the distal humerus in a divergent configuration in both the axial and sagittal planes instead of the coronal plane, with the cross-pin, and with 2 and 3 coronally divergent lateral-pin techniques in a synthetic humerus model of supracondylar humerus fractures. METHODS: Thirty-six identical synthetic models of the humerus simulating a standardized supracondylar humerus fracture were included in this study. They were divided into 4 groups based on the pin configuration of fixation: the new 3-lateral pin-fixation technique (group A), 2 crossed pins (group B), 3 divergent lateral pins (group C), and 2 divergent lateral pins (group D). Each model was subjected to combined axial and torsional loading, and then torsional stability and torsional stiffness (Nmm/°) were recorded. RESULTS: Group A had greater rotational stability than groups C and D but had no statistically significant additional rotational stability compared with group B (P=.042, P=.008, P=.648, respectively), whereas group B had greater rotational stability than only group D (P=.020). Furthermore, group A demonstrated higher internal rotational stiffness compared with groups C and D (P=.038, P=.006, respectively). Group B had better internal rotational stiffness than group D (P=.015). There was no significant difference in internal rotational stiffness between groups A and B (P=. 542), groups B and C (P=.804), and groups D and C (P=.352). Although no statistically significant differences existed between groups A and B, the modified pin configuration exhibited the highest torsional stability and stiffness. Group D showed the lowest values in all biomechanical properties. CONCLUSION: This study has shown us that this new lateral-pinning technique may provide torsional resistance to internal rotational displacement as strong as the standard technique of crossed-pin configuration of fixation. Furthermore, with this new pin configuration, greater torsional resistance can be obtained than with either the standard 2- or the standard 3-lateral divergent pin configuration. Cite this article as: Bilgili F, Demirel M, Birisik F, Balci HI, Sunbuloglu E, Bozdag E. A new configuration of lateral-pin fixation for pediatric supracondylar humeral fracture: A biomechanical analysis. Acta Orthop Traumatol Turc., 2023 10.5152/j.aott.2024.21091 [Epub Ahead of Print].

The Effects of Cross-Linking Agents on the Mechanical Properties of Poly (Methyl Methacrylate) Resin.

Cross-linking agents are incorporated into denture base materials to improve their mechanical properties. This study investigated the effects of various cross-linking agents, with different cross-linking chain lengths and flexibilities, on the flexural strength, impact strength, and surface hardness of polymethyl methacrylate (PMMA). The cross-linking agents used were ethylene glycol dimethacrylate (EGDMA), tetraethylene glycol dimethacrylate (TEGDMA), tetraethylene glycol diacrylate (TEGDA), and polyethylene glycol dimethacrylate (PEGDMA). These agents were added to the methyl methacrylate (MMA) monomer component in concentrations of 5%, 10%, 15%, and 20% by volume and 10% by molecular weight. A total of 630 specimens, comprising 21 groups, were fabricated. Flexural strength and elastic modulus were assessed using a 3-point bending test, impact strength was measured via the Charpy type test, and surface Vickers hardness was determined. Statistical analyses were performed using the Kolmogorov-Smirnov Test, Kruskal-Wallis Test, Mann-Whitney U Test, and ANOVA with post hoc Tamhane test (p ≤ 0.05). No significant increase in flexural strength, elastic modulus, or impact strength was observed in the cross-linking groups compared to conventional PMMA. However, surface hardness values notably decreased with the addition of 5% to 20% PEGDMA. The incorporation of cross-linking agents in concentrations ranging from 5% to 15% led to an improvement in the mechanical properties of PMMA.

The effect of onlay cortical fibula strut grafts on biomechanical features of Vancouver type B1 periprosthetic femoral fractures.

OBJECTIVE: This study aimed to investigate biomechanically the effects of onlay fibula grafts on Vancouver Type B1 Periprosthetic Femoral Fractures (PPFs). METHODS: Vancouver Type B1 PFF models were created in 25 fourth-generation synthetic femurs and fixed with locking plates using bicortical, unicortical screws, and cables. While no graft was used in group 1, onlay fibula grafts were placed anteriorly in group 2 and medially in group 3. In group 4, the cortical strut allograft was placed on the medial femoral cortex, and a locking compression plate (LCP) was applied to the lateral femoral cortex. In group 5, the strut allograft was placed over the anterior cortex of the femur and fixed with the same technique as in group 4. All models were then subjected to rotational and axial cyclical stiffness tests and load to failure to measure and compare the mechanical strengths of the constructs. RESULTS: The mean stiffness values of group 4 with medial allograft, before and after cyclical loading, were higher than all other groups, under both rotational and axial forces. The mean stiffness values of fibula autografts (groups 2 and 3) were similar to that of anterior allografts (group 5) in each test except that the mean initial axial stiffness of group 5 was higher than group 2. Failure loads were also not different between the groups. CONCLUSION: Although the rigidity of Vancouver type B1 periprosthetic femur fractures is highest if allografts are placed medially, fibula autografts can also provide similar fixation strengths to allografts if locking plates with unicortical and bicortical screws and cables are used.

An in-silico approach to modeling orthodontic tooth movement using stimulus-induced external bone adaptation.

Bone remodeling process has been used in orthodontics to treat malposition of teeth in patients by applying stimuli outside of usual everyday loads to promote tooth movement by affecting equilibrium state of the surrounding bone tissue. Accurate modeling of long term orthodontic tooth movement (OTM) is crucial in the field of dental biomechanical research since it allows to predict the behavior and interaction of bone-tooth environment in a non-destructive way, and helps to gain more insight on how exactly tooth motion progresses over time. Existence of such predictive tools might help to avoid the adverse effects of OTM on teeth and the surrounding tissues during this clinical procedure. In this study a new numerical approach to simulating long-term OTM is proposed, that involves external bone adaptation with strain energy density of the bone taken as the stimulus parameter and bone adaptation modeled by nodal movements at the bone-tooth interface using Abaqus UMESHMOTION subroutine. Contrary to conventional re-meshing algorithms, where the mesh of resorbed-apposed bone region is constantly updated and element deletion/creation is performed for each increment, the proposed method only moves nodes without changing the initial mesh topology. For this study, a 3D model of right central maxillary incisor tooth and its surrounding maxillary bone was used for the modeling of OTM for a duration of 1 week. Two test cases were performed and the results from induced tooth motion were investigated. Results indicate tooth movement values that were quite close to clinical values provided in the literature and this method is easily applicable to validate various postulates of OTM via adapting the stimulus-adaption rate relation and patient-specific planning of orthodontic patients as well.

The Effects of Different Screw Combinations on the Initial Stability of Ankle Arthrodesis.

Background: The literature is scanty regarding the biomechanical effects of different thread configurations on the initial stability of ankle arthrodesis. This study aims to compare the initial stability of tibiotalar fusion site in ankle arthrodesis using cannulated screws with different thread designs. Methods: We biomechanically tested under cyclic loading the effects of different screw combinations on the initial stability of ankle arthrodesis. A total of 28 synthetic ankle models were divided into four groups: two partially threaded cancellous screws (group A), partially and fully threaded cancellous screws (group B), a partially threaded cancellous screw with a headless compression screw (group C), and a fully threaded cancellous screw and a headless compression screw (group D). Biomechanical variables including ultimate failure load, initial stiffness, ultimate stiffness, and failure angulation were analyzed. Results: There were no differences in any of the biomechanical variables among the four groups (P = .41 for ultimate failure load, P = .079 for initial stiffness, P = .084 for ultimate stiffness, and P = .937 for failure angulation). Conclusions: Combinations of different cannulated screws showed similar results in terms of the stability and stiffness of the tibiotalar fusion site.

Evaluation of strain distribution on an edentulous mandible generated by cobalt-chromium metal alloy fixed complete dentures fabricated with different techniques: An in vitro study.

STATEMENT OF PROBLEM: Fixed complete dentures (FCDs) have been used in the treatment of completely edentulous patients for over 40 years. However, few reports have investigated misfit values and strain distribution in the context of FCDs fabricated with new technologies. PURPOSE: The purpose of this in vitro study was to evaluate misfit values and strain distribution in FCDs and their relation to the fabrication technique of the cobalt-chromium (Co-Cr) metal framework. MATERIAL AND METHODS: Four implants were placed in the interforaminal region of a mandibular cast at the bone level. The Co-Cr metal alloy frameworks were fabricated using the following techniques: computer-aided design and computer-aided manufacturing (CAD-CAM), milling from hard blocks, CAD-CAM milling from soft blocks, and direct metal laser sintering (DMLS). The superstructures of equal sizes with acrylic resin bases and acrylic resin denture teeth were fabricated on the Co-Cr metal alloy framework, and a digital microscope was then used to measure the misfit between the abutments and the implants. The stress formed after the application of torque was measured with a strain-gauge stress analysis technique. Data were statistically analyzed using 1-way ANOVA and the Tukey Honestly Significant Difference test (α=.05). The correlation between the misfit and the strain values was evaluated with the Pearson Correlation test (α=.001). RESULTS: The lowest mean misfit values (99 ±17 µm) were observed in the hard block group (P<.05) and the highest in the DMLS group (139 ±29 µm). A statistically significant positive relationship was found between the misfit and the stress distribution after torque application (P<.05). Moreover, the lowest misfit group, hard blocks, had the lowest mean strain values (81.1 ±54 MPa) after torque application. CONCLUSIONS: Within the limitations of this in vitro study, the fabrication technique used for Co-Cr metal alloy frameworks appears to influence the passive fit significantly (P<.05). The hard-block technique was found to be the most precise fabrication technique for Co-Cr metal alloy frameworks. A significant relationship was observed between the amount/distribution of misfit and the strain on the FCD (P<.05).

Comparison of two different superior capsule reconstruction methods in the treatment of chronic irreparable rotator cuff tears: a biomechanical and histologic study in rabbit models.

BACKGROUND: In the treatment of irreparable rotary cuff (RC) tears, the superior capsule of the shoulder is reconstructed using tensor fascia lata (TFL) or several allografts to prevent progressive joint degeneration. This study compared the healing qualities of acellular human dermal graft (HDG) and the TFL autograft in superior capsule reconstruction (SCR) from biomechanical and histologic perspectives. METHODS: Chronic retracted RC tear models were created bilaterally in 9 rabbits, and 7 rabbits with intact RC were used as a control group. SCR was performed 8 weeks after the tear using HDG in right shoulders and TFL in left shoulders. At 12 weeks after SCR, 2 shoulders from each experimental group were investigated for histologic healing, and 7 samples from the experimental and control groups were biomechanically tested. RESULTS: Complete healing was observed macroscopically in the glenoid and humeral sides of both groups. No difference was observed in the enthesis maturation scores between the experimental groups. Collagen fiber density was higher and the orientation was better in TFL group. Inflammatory cell infiltration was not seen in the TFL group, but inflammatory cell infiltration was pronounced in the HDG group. The mean pullout strengths of the TFL group, HDG group, and intact RC group were 139.7 ± 40.5 N, 123.9 ± 47.9 N, and 105.1 ± 11.8 N (P = .187), respectively. The mean stiffness values (P = .711), yield forces (P = .404), and displacements (P = .135) were also statistically not different between the groups. CONCLUSION: In SCR, the healing qualities of HDG and TFL were similar in rabbit models.

Biomechanical comparison of oblique and step-cut osteotomies used in total hip arthroplasty with femoral shortening.

BACKGROUND: Various types of shortening osteotomies and prosthesis are used for femoral reconstruction in total hip arthroplasty of the high hip dislocation. This biomechanical study investigates whether step-cut osteotomies result in better stability than oblique osteotomies and cylindrical femoral stems enhance stability of the osteotomy more than conical stems, and which osteotomy and prosthesis type maintain the stability better after cyclical loading. METHODS: Oblique and step-cut shortening osteotomies were compared under axial and rotational forces, using synthetic femur models and conical or cylindrical femoral prostheses. The models underwent cyclic loading for 10,000 cycles at 3 Hz (100-1000 N axial bending or 0.5-10 Nm torque). After the completion of cyclic loading, the models were loaded until failure. Stiffness values before and after cyclical loading, and failure loads were the outcome parameters. Relative displacements at the osteotomy sites were also measured using 3-Dimensions Digital Imaging Correlation System. RESULTS: The mean failure load was significantly higher in conical prosthesis groups under axial forces. In torsion tests, the mean stiffness of conical prosthesis groups after cyclical loading was higher in oblique osteotomies. The other parameters were similar between the groups. CONCLUSIONS: According to the results of the study, although some individual statistically significant parameters were obtained, step-cut osteotomies, which are technically challenging procedures, were not found biomechanically superior to oblique osteotomies, with neither conical nor cylindrical prostheses.

A New Mini-External Fixator for Treating Hallux Valgus: A Preclinical, Biomechanical Study.

Proximal metatarsal osteotomy is the most effective technique for correcting hallux valgus deformities, especially in metatarsus primus varus. However, these surgeries are technically demanding and prone to complications, such as nonunion, implant failure, and unexpected extension of the osteotomy to the tarsometatarsal joint. In a preclinical study, we evaluated the biomechanical properties of the fixator and compared it with compression screws for treating hallux valgus with a proximal metatarsal osteotomy. Of 18 metatarsal composite bone models proximally osteotomized, 9 were fixed with a headless compression screw and 9 with the mini-external fixator. A dorsal angulation of 10° and displacement of 10 mm were defined as the failure threshold values. Construct stiffness and the amount of interfragmentary angulation were calculated at various load cycles. All screw models failed before completing 1000 load cycles. In the fixator group, only 2 of 9 models (22.2%) failed before 1000 cycles, both between the 600th and 700th load cycles. The stability of fixation differed significantly between the groups (p < .001). The stability provided by the mini-external fixator was superior to that of compression screw fixation. Additional testing of the fixator is indicated.

The use of dermal automesh for incidental hernia repair in abdominoplasty: Clinical, biochemical, and radiological results.

Abdominal wall hernias are often diagnosed on clinical examination or encountered intraoperatively during an abdominoplasty. The aim of this study is to evaluate the long-term results of the use of dermal automesh for the repair of incidental hernias during abdominoplasty operations, and to perform a comparative analysis of the biomechanical strengths of dermal automesh vs biological tissue graft. Between 2008-2012, dermal automesh was used in 12 patients for hernia repair. After repair of hernia, dermal automesh was applied over the repaired area in an onlay fashion. Postoperative follow-up was performed by physical examination and magnetic resonance imaging (MRI) of the abdominal wall. Biomechanical test was performed with prepared samples from excised abdominal panniculus for tensile strength and yield power. Mean age was 45 years (range = 36-54 years). Total follow-up was 26 (14-52) months. MRI studies showed that there were no hernias or defects of the anterior abdominal wall. The tensile strength of the dermal mesh was measured as 15.9 ± 6.0 Mpa (6.4-24.5), maximum load before yield measured 680 ± 175.2 N (336.0-856.0). In conclusion, dermal automesh is a useful option for surgeons who encounter undiagnosed hernias during abdominoplasties.

Stress analysis of a complete maxillary denture under various drop impact conditions: a 3D finite element study.

Complete maxillary dentures are one of the most economic and easy ways of treatment for edentulous patients and are still widely used. However, their survival rate is slightly above three years. It is presumed that the failure reasons are not only due to normal fatigue but also emerge from damage based on unavoidable improper usage. Failure types other than long-term fatigue, such as over-deforming, also influence the effective life span of dentures. A hypothesis is presumed, stating that the premature/unexpected failures may be initiated by impact on dentures, which can be related to dropping them on the ground or other effects such as biting crispy food. Thus, the behavior of a complete maxillary denture under impact loading due to drop on a rigid surface was investigated using the finite element method utilizing explicit time integration and a rate-sensitive elastoplastic material model of polymethylmethacrylate (PMMA). Local permanent deformations have been observed along with an emphasis on frenulum region of the denture, regardless of the point of impact. Contact stresses at the tooth-denture base were also investigated. The spread of energy within the structure via wave propagation is seen to play a critical role in this fact. Stress-wave propagation is also seen to be an important factor that decreases the denture's fatigue life.

Finite element simulation of the behavior of the periodontal ligament: a validated nonlinear contact model.

Due to its significance in tooth movement, the stress/deformation field of periodontium and the alveolar bone remodeling process, periodontal ligament (PDL) cannot be excluded from the studies investigating dental biomechanics regarding its excessive deformability. Therefore, many analytical and numerical researches are carried out to simulate its response and to create a constitutive model via experiments intending to discover the material properties of PDL. The aim of this study is to formulate a user specified contact model that can be used in conjunction with finite element (FE) software and reflects PDL's influence on neighboring structures based on the currently available information, without requiring an actual volumetric finite element mesh of ligament. The results show good agreement with available experimental tooth mobility data. Smooth stress fields are obtained on the tooth root and alveolar bone, which is a significant aspect in bone-remodeling studies. The advantage of simulating PDL as a contact model at the interface of tooth root and the alveolar process instead of a solid-meshed FE model with poor geometric morphology and/or very dense mesh is expected to save pre/post-processing workforce, to increase the accuracy and to contribute to the smoothness of interface stress distributions.

The effect of strut allograft and its position on Vancouver type B1 periprosthetic femoral fractures: a biomechanical study.

The aim of this study is to assess the biomechanical advantage of adding strut allograft and the effect of its position on the construct in Vancouver type B1 fractures. Fifteen forth-generation synthetic femurs were used and created a fracture model at the tip of prosthesis, and subsequently fixated with a lateral plate only, lateral plate and medial strut, lateral plate and anterior strut. Rotational and axial tests were performed. In all loading tests, the plate with medial strut group was stiffer than the other constructs and had higher failure load values and had less displacement in the fracture site. A combination of a plate with a medial strut allograft provides more mechanical stability on periprosthetic femoral fractures near the tip of a total hip arthroplasty.

Retention and surface changes of zirconia primary crowns with secondary crowns of different materials.

OBJECTIVES: To evaluate zirconia as a substitute for gold alloy in primary crowns facing secondary crowns manufactured with different materials, in terms of long-term retention force changes, wear, and phase transformation was aimed. MATERIALS AND METHODS: A total of 12 groups, each containing six samples, consisting of gold alloy primary crown-electroformed gold secondary crowns (AA), zirconia primary crown-electroformed gold secondary crowns (ZA) and zirconia primary crown-casted non-precious alloy secondary crowns (ZC) with conus angles of 0°, 2°, 4°, and 6° were evaluated. Samples were subjected to 10,000 insertion-separation cycles in artificial saliva and retention force was measured. X-ray diffraction and scanning electron microscope analysis were performed on the sample surfaces. RESULTS: The highest retention forces were obtained from ZC-0° group (72.09-71.26 N) and the lowest were obtained from ZA-4° (12.73-19.44 N) and ZA-6° (5.36-19.73 N) groups in the beginning and after 10,000 cycles, respectively. Retention force increased as the conus angle decreased. The monoclinic phase ratio of the zirconia primary crowns decreased after the experiments. No wear was observed in zirconia primary crowns except for the ZC-0° and ZC-2° groups. The use of zirconia primary crowns resulted in a less excursive retention force. CONCLUSIONS: A more predictable and less excursive retention force can be obtained using a hard and rigid primary crown material like zirconia. CLINICAL RELEVANCE: Despite a lack of knowledge about the aging of zirconia without a veneer layer in the oral environment, zirconia primary crowns are more advantageous in terms of retention force development and wear.

In vitro comparison of two different materials for the repair of urethan dimethacrylate denture bases.

PURPOSE: The purpose of this in vitro study was to investigate the flexural properties of a recently introduced urethane dimethacrylate denture base material (Eclipse) after being repaired with two different materials. MATERIALS AND METHODS: Two repair groups and a control group consisting of 10 specimens each were generated. The ES group was repaired with auto-polymerizing polymer. The EE group was repaired with the Eclipse. The E group was left intact as a control group. A 3-point bending test device which was set to travel at a crosshead speed of 5 mm/min was used. Specimens were loaded until fracture occurred and the mean displacement, maximum load, flexural modulus and flexural strength values and standard deviations were calculated for each group and the data were statistically analyzed. The results were assessed at a significance level of P<.05. RESULTS: The mean "displacement", "maximum load before fracture", "flexural strength" and "flexural modulus" rates of Group E were statistically significant higher than those of Groups ES and EE, but no significant difference (P>.05) was found between the mean values of Group ES and EE. There was a statistically significant positive relation (P<.01) between the displacement and maximum load of Group ES (99.5%), Group EE (94.3%) and Group E (84.4%). CONCLUSION: The more economic and commonly used self-curing acrylic resin can be recommended as an alternative repair material for Eclipse denture bases.

The impact of frenulum height on strains in maxillary denture bases.

PURPOSE: The midline fracture of maxillary complete dentures is a frequently encountered complication. The purpose of this study was to assess the effect of frenulum height on midline strains of maxillary complete dentures. MATERIALS AND METHODS: A removable maxillary complete denture was fabricated and duplicated seven times. Four different labial frenulum heights were tested for stresses occurring on the palatal cameo surface. The strains were measured with strain gauges placed on 5 different locations and the stresses were calculated. To mimic occlusal forces bilaterally 100 N of load was applied from the premolar and molar region. RESULTS: A statistically significant association between the height of the labial frenulum and the calculated stresses and strains was shown (P<.05) predominantly on the midline and especially on the incisive papilla. The results showed that stress on the anterior midline of the maxillary complete denture increases with a higher labial frenulum. CONCLUSION: Within the limitations of this in vitro study, it can be concluded that the stress on the anterior midline of the maxillary complete denture increases with a higher labial frenulum. Surgical or mechanical precautions should be taken to prevent short-term failure of maxillary complete dentures due to stress concentration and low cycle fatigue tendency at the labial frenulum region.

The influence of the attachment type and implant number supporting mandibular overdentures on stress distribution: an in vitro study, part I.

OBJECTIVES: The main goal of this study was to compare the stress distribution of mandibular overdentures (OVD) with different numbers of supporting implants and single versus splinted attachment types. MATERIALS AND METHODS: Four different biting situations were simulated for the 2-, 3-, and 4-implant retentive anchor as well as bar attachment OVDs on a formalin-fixed cadaver mandible, and strains were recorded under vertical loading of 100 N. RESULTS: The calculated von Mises values from measured strains in all measurement sites and loading conditions for nonsplinted attachments (retentive anchor) were higher than splinted (bar) attachments. CONCLUSIONS: It may be concluded that in cases with low quality and quantity of bone, the increase in number of implants and the use of a splinted attachment should be preferred to reduce forces emerging around the implants during function. The use of 2 single attachments in cases with good bone quality and ideal size implants still seems to be a safe and sufficient solution for the treatment of mandibular edentulism with OVDs.

The influence of suture material on the strength of horizontal mattress suture configuration for meniscus repair.

PURPOSE: Comparison of the mechanical characteristics of meniscal repair fixation using horizontal sutures and six different sutures under submaximal cyclic and load to failure test conditions may aid physicians in selecting a suture type. METHODS: A 2-cm long anteroposterior vertical longitudinal incision was created in six groups of bovine medial menisci. Lesions were repaired using a No. 2 suture either composed of polyester or polyester and ultra high-molecular weight polyethylene (UHMWPE), or UHMWPE and polydioxanone or pure UHMWPE. Endpoints included ultimate failure load (N), pull-out stiffness (N/mm), pull-out displacement (mm), cyclic displacement (mm) after 100cycles, after 500cycles, and mode of failure. RESULTS: Polyester suture had lower ultimate load than all groups except the suture composed of polyester and UHMWPE (P<.05). Pure UHMWPE suture had higher ultimate failure load than sutures composed of either polyester or polyester plus UHMWPE (P<.05). Predominant failure mode was suture cutting through the meniscus for the groups except for polyester suture which failed by suture rupture. CONCLUSION: Under cyclic loading conditions in bovine meniscus, braided polyester suture fixation provided lower initial fixation strength than fixation with various high strength sutures composed of pure UHMWPE or a combination of absorbable monofilament polydioxanone and UHMWPE, except for combination of polyester and UHMWPE sutures. CLINICAL RELEVANCE: Present study does not support the usage of the braided polyester sutures instead of high strength sutures composed either partially or totally of ultra-high molecular weight polyethylene for the horizontal suture configuration of meniscus repair.

Experimental parameter estimation method for nonlinear viscoelastic composite material models: an application on arterial tissue.

This study is aimed at setting a method of experimental parameter estimation for large-deforming nonlinear viscoelastic continuous fibre-reinforced composite material model. Specifically, arterial tissue was investigated during experimental research and parameter estimation studies, due to medical, scientific and socio-economic importance of soft tissue research. Using analytical formulations for specimens under combined inflation/extension/torsion on thick-walled cylindrical tubes, in vitro experiments were carried out with fresh sheep arterial segments, and parameter estimation procedures were carried out on experimental data. Model restrictions were pointed out using outcomes from parameter estimation. Needs for further studies that can be developed are discussed.

Horizontal suture placement influences meniscal repair fixation strength.

PURPOSE: This in vitro biomechanical study investigated the influence of horizontal suture placement distance from the medial meniscal lesion repair site on fixation characteristics during submaximal cyclic and load to failure test conditions. METHODS: Eighteen cadaveric (20-45 years of age) medial menisci with intact joint capsules were harvested within 24-48 h after death and divided into two groups of 9 specimens each for biomechanical testing. A 2.0-cm-long antero-posterior vertical longitudinal lesion was created with a #15 scalpel 2.0-3.0 mm from the outer edge of each meniscus. Menisci were repaired using #2-0 suture material with two horizontal suture loops placed either 1.0 mm (Group 1) or 3.0 mm (Group 2) from the lesion site. Following repair, the lesion was extended completely through the meniscal horns so that no tissue secured the repair, only the two horizontal suture loops representing a "worst-case" testing scenario. Following repair, specimens were placed in a servo hydraulic device using a pair of 1.2-mm-diameter steel wire loops and underwent submaximal cyclic loading between 5 and 50 N (1 Hz) for 500 cycles prior to load to failure testing (5 mm/min crosshead speed, 20 Hz data collection). An alpha level of P < 0.05 was selected to indicate statistical significance. RESULTS: Five of nine (55.6 %) Group 1 specimens did not complete submaximal cyclic testing. All Group 2 specimens completed submaximal cyclic testing (Fisher's exact test P = 0.029). Statistically significant mean group differences were not observed for displacement during submaximal cyclic loading (Group 1 = 5.0 ± 1.5 mm and Group 2 = 5.7 ± 1.6 mm) or for construct stiffness during load to failure testing (Group 1 = 50.1 ± 6.3 N/mm and Group 2 = 52.6 ± 11.9 N/mm). Group 2 displayed greater mean load at failure (112.1 ± 40.8 N vs. 72.7 ± 11.2 N, P = 0.02) and mean displacement at failure (11.1 ± 2.2 mm vs. 7.6 ± 1.4 mm, P = 0.03) than Group 1. CONCLUSIONS: Horizontal sutures placed slightly farther away from the meniscus lesion displayed superior repair fixation than sutures placed closer to the lesion. The superior biomechanical meniscal repair fixation provided by capturing greater tissue volume may enable safe earlier participation in functional exercise activities. Studies are needed to verify these findings in vivo.