1.
Bioorg Med Chem Lett
; 18(14): 4087-91, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18602260
RESUMEN
The induction of conformationally restricted N-(aryl or heteroaryl)-3-azabicyclo[3.1.0]hexane derivatives at P(2) region of compounds of 2-cyanopyrrolidine class was explored to develop novel DPP-IV inhibitors. The synthesis, structure-activity relationship, and selectivity against related proteases are delineated.