[Synthesis and antimicrobial activity of some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoyl)-D,L-methionine]. / Sinteza si activitatea antimicrobiana a unor (sulfon-amidofenil)-amide ale N-(m-nitrobenzoil)-D,L-metioninei.

In order to obtain new compounds with potential antimicrobial activity some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-methionine have been synthesized. The compounds have been obtained by decyclization reaction of 2-(m-nitrophenyl)-4-(beta-P-methylthioethyl)- delta2-5-oxazolinone with various sulfonamides. The chemical structure of the new sulfonamides was confirmed by elemental analysis data and IR and 1NMR spectral measurements. The compounds were also investigated for their antimicrobial activity using Staphylococcus aureus, Escherichia coli, Listeria monocytogenes and Proteus vulgaris strains.

[Synthesis and toxicity of some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-asparagine]. / Sinteza si studiul toxicitatii unor (sulfon-amidofenil)-amide ale N-(m-nitrobenzoil)-D,L-asparaginei.

In order to obtain new compounds with potential antibacterial activity some new (sulfonamidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-asparagine have been synthesized. The compounds have been obtained by decyclization reaction of 2-(m-nitrophenyl)-4-(beta-amidomethyl)-delta2-oxazolinone with various sulfonamides. A toxicity study with determination of DL50 value has also been realized.

New derivatives of m-nitrobenzoyl-asparagic acid and m-nitrobenzoyl-asparagine with anti-inflammatory action.

In order to obtain new biologically active compounds some derivatives of 1-[N-(m-nitrobenzoyl)-alpha-D,L-asparaginyl]-2-benzyl-benzimidazole have been synthesized by ring opening reactions of 2-(m-nitrophenyl)-4-(beta-amidomethyl)-delta 2-oxazolin-5-one and 2-(m-nitrophenyl)-4-(beta-carboxymethyl)-delta 2-oxazolin-5-one with 2-benzylbenzimidazole (dibazole).

[Hydrazide derivatives with biologically active 1,2,4-triazole support]. / Derivés de hydrazides avec support de 1,2,4-triazole biologiquement actifs.

This study presents the synthesis of ten new hydrazides with 1,2,4-triazole support. The structures of the obtained compounds were elucidates by means of the elemental analysis data as well as by IR spectral measurements. The antimicrobial and antifungal actions of this derivates are also tested. The results show that the compounds with the functional group 4-chlore-2-methoxyphenyle are more active.

Derivatives of asparagic acid with hypotensive action.

To obtain new compounds with biological activity, 1-[N-(p-nitrobenzoyl)-alpha-D,L- asparagyl]-benzimidazole derivatives were synthesized by decyclization of 2-(p-nitrophenyl)-4-[2'- (diethylamino) ethyl-carboxymethyl]-delta 2-oxazolinone-5 with benzimidazole, 2-methylbenzimidazole and 5,6-dimethyl-benzimidazole. The synthesized products show a hypotensive action comparable to that Hipopresol.

On hypotensive action of some imidazoline derivatives of sulphonamidated aryloxyalkylcarboxylic acids.

New imidazolines derived from sulphonamidated aryloxyalkylcarboxylic acids have been tested for their antihypertensive action and toxicity. The obtained results attest a remarkable biological action, low toxicity and a good absorption in oral administration.