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Due to their poikilothermic nature, fish are very sensitive to changes in temperature. Due to climate change, the average global temperature has increased by 1.5°C in the last century, which may have caused an increase in farmed fish mortality recently. Predictions using the model estimate that a 1°C increase in temperature could cause 3%-4% and 4%-6% mortality due to infectious diseases in organisms living in warm and temperate waters, respectively. There is a need to determine whether there is a relationship between increasing environmental temperature and disease virulence. This review examines the influence and impact of increasing temperatures due to climate change on the physiology and pathogenicity of Streptococcus agalactiae, which causes streptococcosis in tilapia and causes significant economic losses. Changes in the pathogenicity of S. agalactiae, especially its virulence properties due to increasing temperature, require changes in the composition design of the fish vaccine formula to provide better protection through the production of protective antibodies.
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Scientific abstract: R&D serves as one of the imperative aspects in handling the COVID-19 pandemic. Since the Indonesian government has declared the COVID-19 pandemic as a national disaster, a number of accelerated regulations were stipulated, engaging research and innovation acknowledged as Science, technology, and innovation (STI) Policy. The results of the regulation mapping in Indonesia during 2020-2021 include the 9 regulations (categorized as STI Policy and dominated by institutional settings of 44.4%, operational mechanisms of 33.3%, and legal devices of 22.3%) as an attempt to address the COVID-19 pandemic. Hence, it is expected that the implementation of STI Policy plays a role in generating the 50 innovation products through the COVID-19 research and innovation consortium. Public interest abstract: The COVID-19 pandemic has been declared as a national disaster in Indonesia. There are nine regulations in the field of Science, technology, and innovation (STI) Policy set by the Indonesian government until July 2021, which regulate institutions, by institutionalizing the implementation of research and innovation in the health sector. The institution is acknowledged as the COVID-19 Research Consortium, consisting of government R&D institutions, universities, industrial R&D institutions, professional associations, regulators, industry, and 50 research and innovation products which have been launched by this consortium.
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The COVID-19 pandemic has made it difficult to carry out face-to-face training activities in various higher institutions. This has led to a negative impact on the skills and abilities of nursing students in performing cardiopulmonary resuscitation (CPR) and the cessation of their clinical practice programs in hospitals. Therefore, the aim of this study is to determine the efficacy and knowledge of nursing students in performing CPR by implementing a blended learning program, through online learning platforms. The search for full-text articles was carried out in May 2020 and were reviewed to know whether they fit the theme using the ProQuest, ScienceDirect and PubMed databases with the keywords "BLS", "CPR", "Blended learning", "Knowledge" and "Self-efficacy". In addition, there were 15 articles that matched the criteria. The application of a blended learning program that integrates video and face-to-face lectures through online learning platforms in conducting effective CPR, increases the efficacy and knowledge of nursing students. The effectiveness of online learning greatly affects the efficacy and knowledge of nursing students in conducting CPR. Therefore, it was highly recommended during the COVID-19 pandemic.
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This research tried to compare the level of farmers' livelihood vulnerability to flooding in Sukoharjo and Klaten. Farmers are the most susceptible caused by climate change. The data used in this research are primary data, collected by interviewing 61 respondents who are farmers in the Sonorejo Village, Sukoharjo Regency and 72 respondents in the Jiwo Wetan Village, Klaten Regency. This data obtained by using non-probability sampling technique with purposive methods. Meanwhile mapping for hazard level was analysed by using Geographic Information System (GIS). Descriptive statistic was used for the livelihood vulnerability index's (LVI) and the LVI-Intergovernmental Panel on Climate Change's (IPCC) index calculation. The results show that the farmers' livelihood vulnerability in the Sonorejo Village is medium level because of climate change based on the LVI index value at 0.363 and LVI-IPCC index value at 0.044. Meanwhile, the Jiwo Wetan Village has a lower index in LVI at 0.344 and LVI-IPCC index value at 0.038. Areas with similar physical characteristic and most of its community have a dependence on agriculture tend relatively the same level of vulnerability.
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BACKGROUND: Fast Orally Dissolving Film preparation can be used for patients with problems in ingesting solid dosage forms, such as mentally ill, elderly, geriatric and patients who are reducing fluid intake or nausea. AIM: This study aimed to formulate and evaluate the rapid dissolution of amlodipine besylate. METHODS: Amlodipine besylate film was prepared by solvent casting method by using hydroxypropyl methylcellulose (HPMC) as film formers, crospovidone as superdisintegrant with Varian concentration F1 (2%), F2 (4%), F3 (6%) and F4 (8%), PEG 400 as plasticizer, sucralose and sorbitol as sweetener, citric acid as saliva stimulation, and grape essence as flavoring and coloring agent. Characteristics of films include organoleptic, weight uniformity, film thickness, surface pH, swelling, uniformity of content, time of disintegration, and dissolution. RESULTS: All formulated films produced a good film, smooth, transparent and uniform physical properties. F2 with polymer HPMC and the 4% concentration of crospovidone was the best formula with 31.50 seconds of disintegration time, the index expanding at the 15 second by 242.29% and the cumulative percent of the drug at 80 seconds by 98.08%. CONCLUSION: Amlodipine besylate can be formulated into fast orally dissolving film preparations using HPMC and crospovidone polymers so that they may be considered for use in the treatment of hypertension for patients with drug-induced problems in tablet or capsule form.