Asunto(s)
Traumatismos Craneocerebrales/cirugía , Craniectomía Descompresiva/economía , Craniectomía Descompresiva/métodos , Cráneo/cirugía , Adulto , Traumatismos Craneocerebrales/diagnóstico por imagen , Traumatismos Craneocerebrales/economía , Craniectomía Descompresiva/instrumentación , Países en Desarrollo , Femenino , Humanos , Imagen por Resonancia Magnética/economía , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Tomógrafos Computarizados por Rayos X , Adulto JovenRESUMEN
Several thiazolidinediones having chroman moieties were synthesized and evaluated for their euglycemic and hypolipidemic activities. Some of the analogues having an aminoalkyl group as a linker between the chroman ring and 4-[5-(2,4-dioxo-1, 3-thiazolidinyl)methyl]phenoxy moiety seem to be better than troglitazone. In vitro transactivation assays of PPARgamma have been carried out with these glitazones to understand their molecular mechanism. For the first time we have found that some of the unsaturated thiazolidinediones are superior to their saturated counterpart in the in vivo assay. A more potent thiazolidinedione analogue than troglitazone is reported. Pharmacokinetic studies have shown that protection of the OH group in the chroman moiety leads to a decrease in metabolism, thereby resulting in a superior pharmacological profile.