Country of birth and county of residence and association with overweight and obesity-a population-based study of 219 555 pregnancies in Norway.

BACKGROUND: The aim was to study the effect of country of birth, educational level and county of residence on overweight and obesity among pregnant women in Norway. METHODS: Observational study based on Medical Birth Registry Norway and Statistics Norway. The study population consisted of 219 555 deliveries in 2006-2014. Body mass index (BMI) was registered at the first antenatal care visit. Multivariate regression analysis was used to explore the study aims. RESULTS: Overweight (BMI 25-29.9) was recorded in 22.3% of the women, obesity (BMI ≥30) in 12.2%. Highest rates of overweight (30.8%) and obesity (13.5%) was recorded among women from the Middle East and North Africa or with no education (30.7% and 17.2%). The prevalence of overweight and obesity was 39.5% in sparsely populated counties and 26.4% for women living in Oslo. Adjusted for country of birth, education level, age, parity, smoking and marital status, the relative odds of overweight and obesity were 65% (95% CI 59-72%) higher in sparsely populated counties compared to Oslo. CONCLUSIONS: The prevalence of overweight (BMI ≥25) was 34.5%. The factors associated with overweight were living in rural districts in Norway, lower education and being born in countries in the Middle East or Africa.

Experimental and theoretical charge density studies at subatomic resolution.

Analysis of accurate experimental and theoretical structure factors of diamond and silicon reveals that the contraction of the core shell due to covalent bond formation causes significant perturbations of the total charge density that cannot be ignored in precise charge density studies. We outline that the nature and origin of core contraction/expansion and core polarization phenomena can be analyzed by experimental studies employing an extended Hansen-Coppens multipolar model. Omission or insufficient treatment of these subatomic charge density phenomena might yield erroneous thermal displacement parameters and high residual densities in multipolar refinements. Our detailed studies therefore suggest that the refinement of contraction/expansion and population parameters of all atomic shells is essential to the precise reconstruction of electron density distributions by a multipolar model. Furthermore, our results imply that also the polarization of the inner shells needs to be adopted, especially in cases where second row or even heavier elements are involved in covalent bonding. These theoretical studies are supported by direct multipolar refinements of X-ray powder diffraction data of diamond obtained from a third-generation synchrotron-radiation source (SPring-8, BL02B2).

Multipole electron-density modelling of synchrotron powder diffraction data: the case of diamond.

Accurate structure factors are extracted from synchrotron powder diffraction data measured on crystalline diamond based on a novel multipole model division of overlapping reflection intensities. The approach limits the spherical-atom bias in structure factors extracted from overlapping powder data using conventional spherical-atom Rietveld refinement. The structure factors are subsequently used for multipole electron-density modelling, and both the structure factors and the derived density are compared with results from ab initio theoretical calculations. Overall, excellent agreement is obtained between experiment and theory, and the study therefore demonstrates that synchrotron powder diffraction can indeed provide accurate structure-factor values based on data measured in minutes with limited sample preparation. Thus, potential systematic errors such as extinction and twinning commonly encountered in single-crystal studies of small-unit-cell inorganic structures can be overcome with synchrotron powder diffraction. It is shown that the standard Hansen-Coppens multipole model is not flexible enough to fit the static theoretical structure factors, whereas fitting of thermally smeared structure factors has much lower residuals. If thermally smeared structure factors (experimental or theoretical) are fitted with a slightly wrong radial model (s(2)p(2) instead of sp(3)) the radial scaling parameters (kappa' parameters) are found to be inadequate and the ;error' is absorbed into the atomic displacement parameter. This directly exposes a correlation between electron density and thermal parameters even for a light atom such as carbon, and it also underlines that in organic systems proper deconvolution of thermal motion is important for obtaining correct static electron densities.

The effective diffusion coefficient and the distribution constant for small molecules in calcium-alginate gel beads.

The effective diffusion coefficient, D(e), and the distribution constant, K(i), for selected mono- and disaccharides and organic acids were determined in homogeneous calcium-alginate gel with and without entrapped bacteria. Results were obtained from transient concentration changes in well-stirred solutions of limited volume, in which the gel beads were suspended. The effective diffusioncoefficients and the distribution constants were estimated by fitting mathematical model predictions to the experimental data using a nonlinear model fitting program (MODFIT). Both single solute diffusion and multiple solute diffusion were performed. A small positive effect was obtained onthe values of D(e) for the system of multiple solute diffusion; however, the values of K(i) were not significantly influenced. For the nine solutes tested, D(e) for 2% Ca-alginate gel beads was found to be approximately 85% of the diffusivity measured in water. The effects on D(e) and K(i), for lactose and lactic acid were determined for variations of alginate concentration, pH, temperature, and biomass content in the beads. D(e) decreased linearly for both lactose and lactic acid with increasing cell concentration in the Ca-alginate gel. K(i), was constant for both lactose and lactic acid with increasing cell concentration. D(e) was significantly lower at pH 4.5 than at pH 5.5 and 6.5 for both lactose and lactic acid. Furthermore, D(e) seemed to decrease with increased alginate concentration in the range of 1% to 4%. The diffusion rate increased with increasing temperature, and the activation energy for the diffusion process for both lactose and lactic acid was constant in the temperature range tested. (c) 1995 John Wiley & Sons Inc.

Determination of effective diffusion coefficients and distribution constants in polysaccharide gels with non-steady-state measurements.

A non-steady-state method has been used for determining the effective diffusion coefficient, D(e), and a distribution constant, K(i), of small molecules in alginate gel beads. A mathematical model based on Pick's law and includingexternal film diffusion resistance describe the diffusion process. Criticalexperimental parameters for the estimation of D(e) and K(i), for both one- and two-parameter methods were the initial solute concentration in the bulk liquid, the void fraction inthe reactor, and the experimental starting point. In our analysis, the two-parameter method is preferable. Incorporation of an estimate of the film resistance into the overall model increased the estimated values of D(e) significantly and improved the stability of the term over a range of reactor agitation rates. (c) 1995 John Wiley & Sons Inc.

Soft tissue changes after advancement genioplasty performed as pedicled or free transplants.

The influence of soft tissue attachment in augmentation genioplasty on postoperative soft tissue changes was studied in 25 patients. The soft tissue was completely detached from the advanced genial segment in 14 patients and lingual soft tissue was maintained in 11 patients. The patients were followed for a minimum of 1 year after operation and the soft tissue and bone changes were analysed by measuring linear distances and areas on lateral cephalograms. The result indicated that the soft tissue changes after surgery were significantly different between the two types of graft. In the free grafts there was found to be an increased risk of creating a larger interlabial gap and exposure of the labial surface of mandibular incisors. The higher correlations between hard and soft tissue changes in the pedicled grafts indicated that the predictability is better with this operative technique.

Bone resorption after advancement genioplasty. Pedicled and non-pedicled grafts.

The influence of soft tissue attachment in augmentation genioplasty on the amount of postoperative bone remodelling was studied in 29 patients. The soft tissue was completely detached from the advanced genial segment in 15 patients and the lingual soft tissue was maintained in 14 patients. The advancement of the chin and postoperative bone remodelling was analysed by measuring linear distances and areas on lateral cephalograms. The genial segments with a soft tissue pedicle underwent significantly less resorption than the free grafts (p less than 0.01). The difference in postoperative infection between the two groups (p less than 0.05) indicates that the likelihood of postoperative infection is significantly reduced by maintaining the soft tissue pedicle. Considerably less variation in amount of bone resorption was also observed in the patients with a pedicled graft.

Influence of a single dose of indomethacin on some biochemical changes and postoperative intestinal paralysis following minor surgery. A prospective randomized double-blind study.

The influence of a single dose of indomethacin on the surgical stress response was investigated in a double-blind study including 43 patients scheduled for elective operation of inguinal hernia. Indomethacin or placebo was administered rectally 1 h before the start of operation. All patients had a standardized general anaesthetic. Blood samples for leucocyte count, sedimentation rate, iron and haemoglobin, and measurements of body temperature were taken preoperatively and on the day after surgery. Blood samples for glucose were taken preoperatively, and 4, 8 and 24 h after skin incision. In both groups a significant increase in leucocyte count and sedimentation rate as well as a decrease in serum iron were found, but there was no difference between the groups. Plasma glucose increased from 4 to 8 h after skin incision in the indomethacin group, but not in the placebo group. The postoperative need for methadon, the time needed to regain normal intestinal function and the hospital stay were the same in the two groups, and body temperature showed no change. These findings indicate that a single dose of indomethacin given preoperatively increased plasma glucose but had no effect on the other parameters studied.

The reduction of pain on injection of propofol: the effect of addition of lignocaine.

The effects of addition of 1 ml of lignocaine (10 mg) or isotonic saline to 19 ml of the emulsified preparation of propofol (Diprivan) were studied in a randomised, double-blind trial in 80 patients. The incidence and severity of pain on injection of propofol were significantly reduced by the addition of lignocaine (P less than 0.01).

High-performance liquid chromatographic determination of biogenic amines. II. Comparison of detection methods.

With acidic aqueous mobile phases on silica, detection by electrochemical oxidation on a carbon paste working electrode was compared with detection by the native fluorescence by excitation at 280 nm of catechols and indoles. Based on evaluations of sensitivity, reproducibility, stability, selectively and simplicity of handling, the fluorescence detector was considered superior to the voltammetric detector. Preliminary results from direct injections of deproteinized serum indicated that at levels of at least 10 microgram/1 the content of some indoles in biological fluids could be determined without further sample purification.

Alcoholic cirrhosis of the liver in the Scandinavian countries 1961-1974.

The increase in mortality from alcohol induced cirrhosis of the liver in Sweden, Norway, Finland and Denmark from 1961 to 1974 is compared. Mortality from alcoholic cirrhosis of the liver increased in Finland and Denmark tenfold and fivefold respectively from 1961 to 1974. The increase has been particularly marked since 1968. In Sweden a threefold increase and in Norway a doubling of mortality in males was ascribed to alcohol induced liver cirrhosis. Mortality from non-alcoholic cirrhosis of the liver remained practically unchanged during the period. Increases in mortality from liver cirrhosis due to alcohol abuse run parallel with increases in alcohol consumption; the countries with the highest mortality have the highest consumption. The distribution of consumption of beer, wine and spirit is compared in the four countries: consumption of spirits predominates in Sweden, in Finland spirits and beer, in Denmark beer and wine and in Norway spirits and beer. Doubling of alcohol consumption in a country is followed by a fourfold increase in the number of addicts, and fourfold increase in alcohol induced diseases.