[Peculiarities of pharmacotherapy in patients with chronic heart failure].

A pharmacoepidemiological study of drug consumption was performed on 352 patients with III to IV NYHA functional class chronic heart failure (CHF) in different hospitals of Kursk region. The study found that only 51% of expenses related to pharmacological providence of CHF patients were associated with the drugs used directly for the treatment of CHF. Undesirable drug combinations are used more often in city hospitals and hospitals belonging to certain organizations than in the regional clinical hospital.

[The pharmacoepidemiology of drugs used in treatment of patients with chronic obstructive pulmonary disease].

For one hundred fifty eight patients with chronic obstructive pulmonary disease (COPD) were the subjects of a pharmacoepidemiological study. The study found that both pharmaceuticals indicated for the treatment of this disease, and drugs of low effectiveness, were used in treatment of these patients very intensively. Each hospital led its own policy of the distribution of expenses associated with COPD treatment.

[A comparative clinico-pharmacological study of adalat, foridone, siskor, lomir effects on cerebral and peripheral circulation in patients with arterial hypertension]. / Sravnitel'noe kliniko-farmakologicheskoe izuchenie vliianiia adalata, foridona, siskora, lomira na tserebral'noe i perifericheskoe krovoobrashchenie u bol'nykh arterial'noi gipertenziei.

The results of a comparative clinicopharmacological study of adalate, foridone, siskor and lomir effects on cerebral and peripheral blood flow are presented for 46 patients with arterial hypertension stage I-III. It was found that all the four drugs relieve tonicity and enhance blood flow in a. cerebri media and a. carotis communis. Lomir and adalate had more potent effects on central hemodynamics. A maximal dilating effect on regional peripheral arteries was observed after a single intake of siskor and adalate, while lomir's and foridone's single doses were weaker. In course treatment with the above drugs these differences are less.

[Comparative clinico-pharmacological characteristics of nimodipine, nifedipine and foridon in the treatment of patients with ischemic stroke in late rehabilitative and residual periods]. / Sravnitel'naia kliniko-farmakologicheskaia kharakteristika nimodipina, nifedipina i foridona pri lechenii bol'nykh ishemicheskim insul'tom v pozdnem vosstanovitel'nom i rezidual'nom periodiakh.

A comparative study of pharmacodynamics and clinical efficacy of nimodipine, nifedipine and foridon in ischemic stroke (late recovery and residual period) was performed in 97 patients with ischemic stroke. It was found that nimodipine, nifedipine and foridon at late recovery or residual stages significantly improved higher psychic functions, promoted regression of neurologic disorders and optimized social rehabilitation. Nimodipine, primarily, decreased the intensity of neurological disorders, improved higher psychic functions and had a positive impact on cerebral hemodynamics. Nifedipine primarily improved central hemodynamics (increased stroke output and ejection fraction). Foridon is most effective selective pharmacodynamic impact on peripheral hemodynamics (stimulated arteriolar blood flow, diminished venous capacity and spasticity), i.e. normalized peripheral blood flow.

[Efficiency and safety of a long-lasting form of diltiazem in the treatment of hypertensive patients with ischemic heart disease]. / Izuchenie éffektivnosti i bezopasnosti prolongirovannoi formy diltiazema pri lechenii bol'nykh IBS i arterial'noi gipertenziei.

Antianginal and hypotensive efficacy of etizem was studied in 40 patients with ischemic heart disease (IHD), stable angina of effort (moderate-to-severe) for 4 weeks and 43 patients with arterial hypertension (mild-to-moderate) for 12 weeks. A course treatment with etizem lowered mean 24 hour, mean diurnal and mean nocturnal blood pressure (both systolic and diastolic, normalized blood pressure in most cases of abnormal 24 hour diastolic blood pressure profile. Etizem also significantly improved left ventricular diastolic function but failed to do so in relation to myocardial mass of the left ventricle.

[Pharmacokinetic and pharmacodynamic effects of isradipine in patients with arterial hypertension]. / Izuchenie farmakokineticheskikh i farmakodinamicheskikh éffektov isradipina u bol'nykh arterial'noi gipertenziei.

It was established that a regular administration of isradipine is accompanied by an increase in the mean values of Cmax (by 21.7%) and AUC (by 21.8%), which leads to extension of the pharmacodynamics effects without cumulation (the values of Clt, T1/2, and Tmax remain unchanged). The maximum hemodynamic effect of isradipine upon a single administration in a single dose of 5 mg coincides with the time or reaching the maximum drug concentration in the blood (Tmax). There is a reliable correlation between the hypotensive effect, the peripheral vascular resistance, and the concentration of isradipine.

[The clinical pharmacology and efficacy of the new Soviet calcium antagonist foridon]. / Klinicheskaia farmakologiia i éffektivnost' novogo otechestvennogo antagonista kal'tsiia foridona.

A total of 56 patients with coronary heart disease (CHD), angina pectoris of effort, functional classes II-III, were placed under observation. All the patients received 20 mg foridon (F), 20 mg corinfar (C), 80 mg anapriline (A). 24 patients were subjected to the continuous treatment with F (20 mg 4 times a day). The antianginal action of the drug was compared to the blood concentration on days 7, 14, 21, 28, 43 and 57 of the treatment with F. In 14 patients with angina pectoris and in 18 patients with essential hypertension, the efficacy of F and C was cross correlated. It has been demonstrated that F can be successfully used for the treatment of patients with CHD, angina pectoris of effort and (or) essential hypertension. The increase of the single dose of foridon from 20 to 40 mg does not result in the potentiation of its hypotensive effect. F and C provoke the highest rise of exercise tolerance with combined angina pectoris. Continuous concomitant administration of F and C with A leads to the potentiation of the antianginal action.