Association of irisin and oxidative stress with biochemical parameters in patients with metabolic syndrome.

Background Irisin, a hormone-like myokine, is suspected to have a role in metabolic syndrome (MetS) through regulating energy homeostasis and mediating physical activity. In this regard, the role of irisin and malondialdehyde (MDA) along with some other biochemical parameters in the prediction of MetS was examined in the present investigation. Materials and methods In the present case-control study, 36 subjects diagnosed with MetS according to International Diabetes Federation were considered as cases and were matched in age and gender with 31 healthy participants. The difference of biochemical indicators between cases and controls were determined whether by independent t-test or the Mann-Whitney U-test. The predictors of MetS and insulin resistance (IR) were examined through logistic and linear regressions analysis models, respectively. Results Irisin and MDA were not found to be predictors for MetS in logistic regression; p = 0.258 and p = 0.694, respectively. The IR was found to be the only direct predictor of MetS (p = 0.010). Similarly, in linear regression, irisin and MDA were not identified to be predictors for IR; p = 0.801 and p = 0.781, respectively. Conclusions The study did not show that irisin and MDA, directly and indirectly, were predictors of MetS disorder. The IR was only predictor of MetS.

Circulating betatrophin in relation to metabolic, inflammatory parameters, and oxidative stress in patients with type 2 diabetes mellitus.

AIMS: Recently, it was suggested that betatrophin has a role in controlling pancreatic ß cell proliferation and lipid metabolism, however, its role in human subjects has not been established yet. The predicting role of betatrophin and MDA along with other biochemical indicators in type 2 diabetes mellitus (T2DM) in a sample of the Iraqi population was examined in the present investigation. METHODS: A total of 31 patients diagnosed with T2DM and 30 adult subjects without diabetes were matched in age and gender in a case-control study. Logistic and linear regression models were performed to examine the role of MDA and betatrophin in T2DM and triglyceride, respectively. RESULTS: The study confirmed a higher concentration of LDL (124.45 vs. 102.70 mg/dL; P = .001) and TG (191.13 vs. 103.83 mg/dL; P < .0001), insulin (18.40 vs. 10.97 µU/mL; P < .0001), and Hs. CRP (5.39 vs. 2.80 mg/L; P = .033) in diabetic patients compared to the controls. No significant difference in betatrophin and MDA was found between diabetic patients and non-diabetic healthy subjects. The study showed triglyceride as the only predictor of T2DM (P = .028). Similarly, total cholesterol (P < .0001), HDL (P = .001), LDL (P < .0003), and MDA (P = .010) were shown as predictors of triglyceride in diabetic patients. CONCLUSION: The present study that triglyceride is a direct and MDA is an indirect predictor for T2DM.