RESUMEN
The use of nanoparticle photothermal effect as adjuvants in neuromodulation has recently received much attention, with many open questions about new nanostructures' effect on the action potential. The photothermal properties of hexagonal gold nanoparticles are investigated in this work, including the absorption peak wavelength and light-heat conversion rate, using both experimental and simulation methods. Furthermore, the ability to use these nanostructures in axonal neural stimulation and cardiac stimulation by measuring temperature changes of gold nano-hexagons under 532 nm laser irradiation is studied. In addition, their thermal effect on neural responses is investigated by modeling small-diameter unmyelinated axons and heart pacemaker cells. The results show that the increase in temperature caused by these nano-hexagons can successfully stimulate the small diameter axon and produce an action potential. Experiments have also demonstrated that the heat created by gold nano-hexagons affects toad cardiac rhythm and increases T wave amplitude. An increase in T wave amplitude on toad heart rhythm shows the thermal effect of nano hexagons heat on heart pacemaker cells and intracellular ion flows. This work demonstrates the feasibility of utilizing these nanostructures to create portable and compact medical devices, such as optical pacemakers or cardiac stimulation.