RESUMEN
We have used the promoter, 1st exon and 1st intron of the maize polyubiquitin gene (Ubi-1) for rice transformation experiments and revealed the characteristic expression of Ubi-1 gene: (1) Ubi-1 gene is not regulated systemically but rather individual cells respond independently to the heat or physical stress; (2) Ubi-1 gene changes its tissue-specific expression in response to stress treatment; (3) the expression of Ubi-1 gene is dependent on cell cycle.
Asunto(s)
Biopolímeros/genética , Regulación de la Expresión Génica de las Plantas , Genes de Plantas/genética , Oryza/metabolismo , Ubiquitinas/genética , Zea mays/genética , Acetiltransferasas/biosíntesis , Acetiltransferasas/genética , Adaptación Fisiológica/genética , Biopolímeros/biosíntesis , Exones/genética , Glucuronidasa/biosíntesis , Glucuronidasa/genética , Herbicidas/farmacología , Calor , Intrones/genética , Compuestos Organofosforados/farmacología , Oryza/efectos de los fármacos , Oryza/genética , Brotes de la Planta/metabolismo , Plantas Modificadas Genéticamente/efectos de los fármacos , Poliubiquitina , Regiones Promotoras Genéticas/genética , Proteínas Recombinantes de Fusión/biosíntesis , Distribución Tisular , Ubiquitinas/biosíntesisRESUMEN
We treated perennial nasal allergy with specific desensitization in combination with or without Neurotropin injections (NSP) from March 1983 to September 1984, and analyzed blood anti-mite IgG and IgG4 levels in relation to therapeutic efficacy. Desensitization and NSP were given once a week and seventy subjects (33 from the desensitization group and 37 from the desensitization + NSP group) were evaluated at 24, 36 and 48 weeks. 1) In total cases clinical usefulness showed no significant difference between the desensitization group and combined group at 24 weeks, while in "useful or more" cases significantly better results were attained in the latter at 24 weeks and 48 weeks (p less than 0.05, respectively). 2) Dermatophagoides pteronyssinus (D.p.) specific IgG antibody showed no significant difference between both groups as well as in each group during the overall examination period. 3) In total cases both D.p. specific and D. farinae (D.f.) specific IgG4 were significantly higher in the combined group at 24 and 36 weeks (D.p.: p less than 0.01 and D.f.: p less than 0.05, respectively), whereas in "useful or more" cases only D.p. specific IgG4 showed a significant elevation in the combined group at 24 weeks (p less than 0.05). These results suggest that specific desensitization in combination with NSP can promote early production of mite specific IgG4, which tend to rise in correlation with clinical efficacy.
Asunto(s)
Adyuvantes Inmunológicos , Desensibilización Inmunológica , Inmunoglobulina G/análisis , Ácaros/inmunología , Polisacáridos/uso terapéutico , Rinitis Alérgica Perenne/terapia , Adolescente , Adulto , Animales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Rinitis Alérgica Perenne/inmunologíaRESUMEN
The effect of flunarizine, a calcium antagonist, on experimentally induced facial nerve injury in guinea pigs was studied electron microscopically. In flunarizine-untreated animals, intra-axonal accumulation of cell organelles and degradation of myelin sheaths were observed. In flunarizine-treated animals, these changes were not observed, but a knob-like protrusion of myelin sheaths and a structure resembling the myelin sheath in Schwann cell cytoplasm was occasionally observed.
Asunto(s)
Nervio Facial/irrigación sanguínea , Parálisis Facial/tratamiento farmacológico , Flunarizina/uso terapéutico , Isquemia/tratamiento farmacológico , Animales , Axones/ultraestructura , Nervio Facial/ultraestructura , Parálisis Facial/patología , Cobayas , Isquemia/patología , Masculino , Microscopía Electrónica , Vaina de Mielina/ultraestructuraRESUMEN
A case of acute polyradiculoneuritis accompanied by rare complications of the VII, VIII and IX cranial nerve disorder was described. There was an elevation of the rubella virus antibody titer, which suggested the case had been infected before. Thirty-eight year-old woman complained of bilateral tinnitus and was proven audiometrically to have sensori-neural hearing loss. Electroacoustical examination disclosed that all the waves were suppressed and that wave I and V were barely detected, while wave II, III and IV were absent. The neurological and audiological disorders were successfully treated with corticosteroid, and the patient had neither sequelae nor recurrence.
Asunto(s)
Tronco Encefálico/fisiopatología , Potenciales Evocados Auditivos , Pérdida Auditiva Sensorineural/fisiopatología , Polirradiculopatía/fisiopatología , Adulto , Audiometría de Respuesta Evocada , Audiometría de Tonos Puros , Potenciales Evocados Auditivos/efectos de los fármacos , Parálisis Facial/fisiopatología , Femenino , Pérdida Auditiva Sensorineural/tratamiento farmacológico , Humanos , Polirradiculopatía/tratamiento farmacológico , Prednisolona/uso terapéutico , Tiempo de Reacción/fisiología , Rubéola (Sarampión Alemán)/fisiopatología , Acúfeno/fisiopatologíaRESUMEN
CTM was administered at dose levels of 1 to 3 g a day to 77 cases of otorhinolaryngological infections, and the following results were obtained: The effect of the drug was determined in 75 cases. The responders were 3 out of 5 (60.0%) in acute suppurative otitis media, 4 out of 11 (36.4%) in chronic suppurative otitis media, 39 out of 43 (90.7%) in tonsillitis and peritonsillar abscess and 12 out of 16 (75.0%) in other diseases, a total of 58 out of 75 cases (77.3%). The bacteriological effect of CTM was evaluated in 53 cases, and bacterial eradication was demonstrated in 41 cases (77.4%). Also, its antibacterial potency was 2 to 4 times superior in comparison to that of CEZ against isolated bacteria in which MICs were measurable. Side effects which were neither severe nor specific were recognized in 3 out of 77 cases (3.9%). In the cases with abnormal laboratory values, none was determinable to be attributed to CTM.
Asunto(s)
Infecciones Bacterianas/tratamiento farmacológico , Cefotaxima/análogos & derivados , Enfermedades Otorrinolaringológicas/tratamiento farmacológico , Adolescente , Adulto , Anciano , Infecciones Bacterianas/microbiología , Cefotaxima/administración & dosificación , Cefotaxima/efectos adversos , Cefotaxima/uso terapéutico , Cefotiam , Niño , Evaluación de Medicamentos , Femenino , Humanos , Infusiones Parenterales , Inyecciones Intravenosas , Masculino , Persona de Mediana Edad , Enfermedades Otorrinolaringológicas/microbiologíaAsunto(s)
Cefalosporinas/uso terapéutico , Enfermedades Otorrinolaringológicas/tratamiento farmacológico , Infecciones por Pseudomonas/tratamiento farmacológico , Adulto , Cefsulodina , Cefalosporinas/administración & dosificación , Enfermedad Crónica , Ensayos Clínicos como Asunto , Femenino , Humanos , Infusiones Parenterales , Masculino , Persona de Mediana Edad , Otitis Media/tratamiento farmacológicoRESUMEN
Cefmetazole (CMZ), a new cephamycin preparation, has been investigated to give following results. 1) Pharmacokinetics: Serum and tonsil concentration of CMZ were determined by micropore method in humans. The mean concentrations in 5 cases about 30 minutes after administration of 0.5--1.0 g intravenously were 55.4 micrograms/ml in serum, 21.7 micrograms/g in tonsil. 2) CLINICAL STUDIES: Seventy-one patients with ear, nose and throat infections were treated with CMZ receiving 1 to 6 g per day intravenously (one shot and drip infusion). Thirty-eight of 70 patients were cured excellent, 19 were good, 8 were fair and 6 were failure and effective rate was 80.3%. Adverse reaction was observed in 4 cases. Three cases showed exanthema and 1 case showed fever elevation.