RESUMEN
UNLABELLED: The effects of Chinese medicine jiexinkang(JXK) on apoptosis of leukemic cells were studied by morphology approach and electrophoresis of DNA fragments. RESULTS: 1. The apoptotic cells and apoptotic bodies were found by electrical microscopy and the typical ladders of DNA fragments were detected by electrophoresis. 2. JXK induced apoptosis of leukemic cells(HL-60 and K562) in a certain range of concentration and at appropriate time. The time to K562 cell apoptosis was longer than that of HL-60 and its dosage was larger than that of HL-60. CONCLUSION: HL-60 and K562 leukemic cell apoptosis may be induced by JXK and there is correlation between dose and time. The study provides experimental evidences for the clinical treatment of leukemia.
Asunto(s)
Antineoplásicos Fitogénicos/farmacología , Apoptosis/efectos de los fármacos , Medicamentos Herbarios Chinos/farmacología , Fragmentación del ADN , ADN de Neoplasias/análisis , Combinación de Medicamentos , Células HL-60/ultraestructura , Humanos , Células K562/ultraestructuraRESUMEN
The article presents analysis of clinical case of and review of literature on "ALS-dementia complex", a combination of ALS syndrome and dementia predominantly of frontal lobe type. The review of literature contains discussion on the problem of lobe dementia, analysis of relation of ALS-dementia syndrome and the following diseases: Alzheimer, Pick, Creutzfeldt-Jakob, Lewy bodies, Charcot (classic type), multisystem degeneration. Polymorphism of ALS-dementia complex and the possibilities of its differential diagnosis are considered.