Patient-Reported Outcomes Measurement Information System in patients with gastrointestinal cancer: a scoping review.

PURPOSE: The purpose of this study was to identify and evaluate the use of the Patient-Reported Outcomes Measurement Information System in patients with gastrointestinal cancer, as well as provide references for analyzing treatment outcomes, gauging prognostic risk, and assessing clinical symptoms and function in gastrointestinal cancer patients. METHODS: PubMed, Web of Science, ProQuest, Embase, and CINAHL were systematically searched using keywords and controlled vocabulary through January 2023. RESULTS: The scoping review collected 30 studies published from 2012 to 2022, including observational studies (n = 21), interventional studies (n = 4), and mixed studies (n = 5). Outcome indicators included mood, pain, fatigue, sleep, the ability to perform activities of daily living, social functioning, and other health problems. CONCLUSION: Being a self-report questionnaire, the Patient-Reported Outcomes Measurement Information System offers a full assessment of patient's symptoms and quality of life, and accurately captures their actual thoughts, feelings, and experiences. Individuals with gastrointestinal cancer made frequent use of the Patient-Reported Outcomes Measurement Information System to provide an accurate measure of their health status.

Prevalence and affective correlates of subjective cognitive decline in patients with de novo Parkinson's disease.

OBJECTIVES: The novel concept of subjective cognitive decline (SCD) in Parkinson's disease (PD) refers to subjective cognitive impairment without concurrent objective cognitive deficits. This study aimed to determine the prevalence and affective correlates of SCD in de novo PD patients. MATERIALS AND METHODS: A total of 139 de novo PD patients underwent comprehensive neuropsychological evaluation. PD patients with SCD (PD-SCD) did not meet the diagnostic criteria for mild cognitive impairment in PD (PD-MCI) based on the Movement Disorder Society Level II Criteria and were defined by a Domain-5 Score ≥1 on the Non-Motor Symptoms Questionnaire. Affective symptoms were measured using the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA). RESULTS: In de novo PD cohort, the prevalence of SCD was 28.1%. PD-SCD patients performed significantly better than PD-MCI patients on tests of five cognitive domains. The more commonly affected domains in PD-SCD patients were memory (28.2%) and attention/working memory (25.6%). Multivariable linear regression analysis revealed that PD-SCD was significantly associated with both HAMD (ß = 4.518, 95% CI = 0.754-8.281, p = .019) and HAMA scores (ß = 4.259, 95% CI = 1.054-7.464, p = .010). Furthermore, binary logistic regression analysis revealed that higher HAMD (OR = 1.128, 95% CI = 1.019-1.249, p = .020) and HAMA scores (OR = 1.176, 95% CI = 1.030-1.343, p = .017) increased the risk of PD-SCD. CONCLUSIONS: Our findings suggest that SCD is highly prevalent in de novo PD patients. The presence of PD-SCD is suggestive of an underlying affective disorder.

Vascular Stem/Progenitor Cells in Vessel Injury and Repair.

Vascular repair upon vessel injury is essential for the maintenance of arterial homeostasis and function. Stem/progenitor cells were demonstrated to play a crucial role in regeneration and replenishment of damaged vascular cells during vascular repair. Previous studies revealed that myeloid stem/progenitor cells were the main sources of tissue regeneration after vascular injury. However, accumulating evidences from developing lineage tracing studies indicate that various populations of vessel-resident stem/progenitor cells play specific roles in different process of vessel injury and repair. In response to shear stress, inflammation, or other risk factors-induced vascular injury, these vascular stem/progenitor cells can be activated and consequently differentiate into different types of vascular wall cells to participate in vascular repair. In this review, mechanisms that contribute to stem/progenitor cell differentiation and vascular repair are described. Targeting these mechanisms has potential to improve outcome of diseases that are characterized by vascular injury, such as atherosclerosis, hypertension, restenosis, and aortic aneurysm/dissection. Future studies on potential stem cell-based therapy are also highlighted.

Stimulation and Sequestration Mechanism of CO2 Waterless Fracturing for Continental Tight Oil Reservoirs.

CO2 fracturing is a promising technology for oil field development in tight, continental deposits, with potential advantages of enhanced oil recovery (EOR), CO2 sequestration, and water conservation. Compared with CO2-EOR techniques, such as CO2 huff and puff and CO2 flooding, CO2 can interact with reservoir rock and fluid under higher pressure conditions during fracturing, resulting in CO2 stimulation and sequestration effects that differ from those that occur during conventional CO2-EOR. In this paper, the CO2 interactions between CO2 and reservoirs in continental tight oil reservoirs under fracturing conditions are systematically studied through laboratory experiments. The results show that under high pressure, CO2 effectively changes the pore structure through the extraction of hydrocarbons, dissolution of the rock matrix, and migration of minerals. CO2 dissolution of the rock matrix can significantly increase the number and complexity of fractures. Furthermore, CO2 has a higher solubility in formation fluid under high-pressure conditions. Given the higher pressures, CO2 forms a miscible phase with crude oil, diffuses more deeply into the formation, and reacts fully with the reservoir minerals and fluid during CO2 fracturing. Accordingly, CO2 can improve the permeability of the reservoir and flowability of crude oil significantly. Hence, CO2 fracturing can enhance oil recovery and CO2 sequestration more effectively. Core displacement experiments indicate that oil recovery of CO2 soaking process after CO2 fracturing is 36%, which is 12% and 9% higher than those of CO2 huff and puff and CO2 flooding with 5 pore volume, respectively. Field tests show that average oil production after CO2 fracturing is 1.42 times higher than that after CO2 flooding, which further validates the advantage of CO2 fracturing and demonstrates its huge application potential.

Evolution Characteristics of Mechanical Properties under Supercritical Carbon Dioxide Treatment in Shale Reservoirs.

Supercritical carbon dioxide (SC-CO2) has been progressively used in the development of shale oil and gas. However, the interaction between CO2 and shale can change the mineral composition and the pore structure, thus affecting the mechanical properties of shale. To study the influence of SC-CO2 on shale, shale samples collected from the Songliao Basin in China are treated with SC-CO2 at various time intervals. Then, a series of tests are performed, such as the mineral composition analysis test, the pore structure analysis test, and the macro mechanics test. The results show that the mechanical properties of shale gradually decrease exponentially with the increase of SC-CO2 treatment time. The loss of elastic modulus reaches about 47% after the treatment of 14 d. X-ray diffraction analysis shows that the mineral (except quartz) content decreases after SC-CO2 treatment, and in particular, the proportions of carbonate minerals significantly decrease by about 12%. The primary pores and fractures are eroded through dissolution, and new pores and fracture structures are developed on the surface microstructure. In addition, the proportion of micropores and mesopores decreases, while the proportion of macropores increases after SC-CO2 treatment. The specific surface area and average pore size present upward trends during SC-CO2 treatment. The changes of mineral assemblage and pore structure lead to the obvious decline of mechanical properties in shale reservoirs. This study contributes to understanding the evolution characteristics of mechanical properties under SC-CO2 treatment, which is of great significance for the efficient exploitation in shale reservoirs.

Clinical Benefits From Administering Probiotics to Mechanical Ventilated Patients in Intensive Care Unit: A PRISMA-Guided Meta-Analysis.

BACKGROUND: The use of probiotics has been considered as a new intervention for ventilator-associated pneumonia (VAP) prevention in the intensive care unit (ICU). The aim of this meta-analysis was to evaluate the effect of probiotics on mechanical-ventilated patients in ICU. METHODS: PubMed, Embase, Scopus, and the Cochrane Library were searched for relevant randomized controlled trials (RCTs) from their respective inception through October 10, 2021. All studies meeting the inclusion criteria were selected to evaluate the effect of probiotics on patients receiving mechanical ventilation in ICU. RESULTS: A total of 15 studies involving 4,693 participants met our inclusion criterion and were included in this meta-analysis. The incidence of VAP in the probiotic group was significantly lower (odds ratio [OR] 0.58, 95% CI 0.41 to 0.81; p = 0.002; I 2 = 71%). However, a publication bias may be present as the test of asymmetry was significant (p = 0.007). The probiotic administration was associated with a significant reduction in the duration of mechanical ventilation (mean difference [MD] -1.57, 95% CI -3.12 to -0.03; p = 0.05; inconsistency [I]2 = 80%), length of ICU stay (MD -1.87, 95% CI -3.45 to -0.28; p = 0.02; I 2 = 76%), and incidence of bacterial colonization (OR 0.59, 95% CI 0.45 to 0.78; p = 0.0001; I 2 = 34%). Moreover, no statistically significant differences were observed regarding the incidence of diarrhea (OR 0.90, 95% CI 0.65 to 1.25; p = 0.54; I 2 = 12%) and mortality (OR 0.91, 95% CI 0.80 to 1.05; p = 0.19; I 2 = 0%) between probiotics group and control group. CONCLUSION: Our meta-analysis shows that probiotics are associated with a reduction in VAP, as well as the duration of mechanical ventilation, ICU length of stay, and bacterial colonization, but no significant effects on ICU mortality and occurrence of diarrhea. However, in consideration of the significant heterogeneity and publication bias, our findings need to be further validated. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier: CRD42020150770.

The emerging role of the piRNA/piwi complex in cancer.

Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of approximately 24-31 nucleotides in length that often bind to members of the piwi protein family to play regulatory roles. Recently, emerging evidence suggests that in addition to the mammalian germline, piRNAs are also expressed in a tissue-specific manner in a variety of human tissues and modulate key signaling pathways at the transcriptional or post-transcriptional level. In addition, a growing number of studies have shown that piRNA and PIWI proteins, which are abnormally expressed in various cancers, may serve as novel biomarkers and therapeutic targets for tumor diagnostics and treatment. However, the functions of piRNAs in cancer and their underlying mechanisms remain incompletely understood. In this review, we discuss current findings regarding piRNA biogenetic processes, functions, and emerging roles in cancer, providing new insights regarding the potential applications of piRNAs and piwi proteins in cancer diagnosis and clinical treatment.

Emerging function and potential diagnostic value of circular RNAs in cancer.

As a novel class of endogenous RNAs, circRNAs, have a covalently closed continuous loop, with neither a 5'to 3'polarity, nor a polyadenylated tail. Numerous circRNAs have been characterized by abundance, stabilization, conservation, and exhibit tissue/developmental stage-specific expression. Furthermore, circRNAs play vital roles in tumorigenesis and metastasis, such as functioning as a ceRNA or miRNA sponge, interacting with protein and encoding protein. Increasing evidence has revealed that it potentially serves as a required novel biomarker for cancer diagnosis. This review summarized the latest research on circRNAs, including its classification and biogenesis, mechanism and functions, as well as circRNAs in different cancers, as a potential biomarker.

[Acupoint sticking therapy for treatment of bronchial asthma: a multicenter controlled randomized clinical trial].

OBJECTIVE: To observe the effect of acupoint sticking on clinical symptoms and life quality in patients with bronchial asthma. METHODS: Multicenter randomized double-blind clinical trial was done, one hundred and eighty-eight cases were divided into a medication acupoint sticking group (125 cases) and a placebo group (63 cases). Dazhui (GV 14), Feishu (BL 13), Tiantu (CV 22), etc. were selected in both groups. The medication cakes were made of grinding pepper, brassica alba seeds, asarum, etc. into fine powder mixed with ginger oil and ginger juice, applied on acupoints in the acupoint sticking group. While another compound cakes made of powder of red rice, black rice, maize mixed with small amount of ginger juice, were used in the placebo group. Asthma Quality of Life Questionnaire(AQLQ), symptom scores during the day and night, scores of self effect, and the value of lung function were observed. RESULTS: The value of daily behavior and environmental factors of AQLQ, total scores of AQLQ, daytime symptoms and scores of self effect in the medication acupoint sticking group, were significantly improved compared to those of placebo group (all P<0.05). The lung function of forced expiratory volume in one second (FEV1) and the percentage of forced expiratory volume in one second in predicted value (FEV1/FVC) had no significant diffrence between two groups (both P>0.05). CONCLUSION: The acupoint sticking therapy can significantly improve clinical symptoms of patients with bronchial asthma, and can improve life quality of the patients.

Genomic analysis of anti-hepatitis B virus (HBV) activity by small interfering RNA and lamivudine in stable HBV-producing cells.

Hepatitis B virus (HBV) causes acute and chronic hepatitis and hepatocellular carcinoma. Small interfering RNA (siRNA) and lamivudine have been shown to have anti-HBV effects through different mechanisms. However, assessment of the genome-wide effects of siRNA and lamivudine on HBV-producing cell lines has not been reported, which may provide a clue to interrogate the HBV-cell interaction and to evaluate the siRNA's side effect as a potential drug. In the present study, we designed seven siRNAs based on the conserved HBV sequences and tested their effects on the expression of HBV genes following sorting of siRNA-positive cells. Among these seven siRNAs, siRNA-1 and siRNA-7 were found to effectively suppress HBV gene expression. We further addressed the global gene expression changes in stable HBV-producing cells induced by siRNA-1 and siRNA-7 by use of human genome-wide oligonucleotide microarrays. Data from the gene expression profiling indicated that siRNA-1 and siRNA-7 altered the expression of 54 and 499 genes, respectively, in HepG2.2.15 cells, which revealed that different siRNAs had various patterns of gene expression profiles and suggested a complicated influence of siRNAs on host cells. We further observed that 18 of these genes were suppressed by both siRNA-1 and siRNA-7. Interestingly, seven of these genes were originally activated by HBV, which suggested that these seven genes might be involved in the HBV-host cell interaction. Finally, we have compared the effects of siRNA and lamivudine on HBV and host cells, which revealed that siRNA is more effective at inhibiting HBV expression at the mRNA and protein level in vitro, and the gene expression profile of HepG2.2.15 cells treated by lamivudine is totally different from that seen with siRNA.