[Modern principles of the pathogenetic therapy of the burn shock]. / Sovremennye printsipy patogeneticheskoi terapii ozhogovogo shoka.

The article is devoted to the review of main directions of anti-shock therapy improvement for patients with severe burns. It is shown that the treatment efficiency can be considerably increased both by optimization of infusion volume and by the use of modern infusion drugs with anti-hypoxic and anti-oxidant effects. The use of anti-hypoxic and anti-oxidant drugs permits to change the burn shock course and to decrease its duration. Decrease in severity of tissue hypoxia, prevention of cellular membrane injury interrupt one of the circuits of burn disease pathogenesis and create the favorable conditions for realization of acute adaptation mechanisms in terms of traumatic disease conception. The modern schemes of anti-shock therapy approved at the department of thermal injuries were used in the treatment of casualties with combined burns after the armed conflict in the territory of Chechnia (1999-2001).

[Influence of different volumes of infusion therapy on transport and consumption of oxygen in the period of shock in patients with severe burns]. / Vliianie razlichnykh ob"emov infuzionnoi terapii na transport i potreblenie kisloroda v periode shoka u tiazheloobozhzhennykh.

In patients with severe burns during the shock period leading are severe disorders of hemodynamics which are the cause of secondary alterations in the organs and systems. The main method of treatment of such patients is infusion therapy. The approach to determination of the solution volume is ambiguous. A comparative analysis of the influence of infusion medium volumes equal to 10% of the body mass and calculated by the Parkland formula on transport and consumption of oxygen which is the main parameter of the perfusion quality of tissues and organs was made in 58 severe burn patients. The results obtained have confirmed that severe burn patients mainly have the hypodynamic type of blood circulation with altered perfusion of organs and tissues and have shown that the infusion therapy calculated by the Parkland formula results in more valuable stabilization of the function of transport and consumption of oxygen. So, the parameters of blood oxygenation and of oxygen extraction become normalized, metabolic disorders and functional instability of the organs disappear in shorter terms.

[Electron microscopic research on the venous valves of the lower extremities in varicose veins]. / Elektronno-mikroskopicheskoe issledovanie klapanov ven nizhnikh konechnostei pri varikoznoi bolezni.

Electron microscopy of the venous valves in varicose disease shows that dystrophic changes develop on the external and internal surfaces of the valve cusps. Endotheliocytes on the external surface are located longitudinally in relation to valvular axis and on the internal surface they are perpendicular to it. Fragments of the elastic membrane, collagen fibres and smooth muscle cells are seen under the endothelial lining. Endothelium actively regulates proliferative processes of smooth cells secreting the so-called "growth factor of endothelial origin". The development of venous valve pathological changes in varicose disease is accompanied by endothelial damage, disturbance of morphofunctional state of smooth muscle cells and intercellular substance of the vascular wall.