RESUMEN
OBJECTIVE: A possible impairment in hip proprioception after total hip arthroplasty (THA) has been an issue of concern. The aims of this study were to investigate the extent of early postoperative change in standing hip rotation angle (HRAng) in patients with osteoarthritis (OA) undergoing THA and to consider a possible mechanism behind this. MATERIALS AND METHODS: A total of 82 hips (82 patients; 63 women and 19 men) undergoing unilateral primary THA with total capsulectomy were included. We characterized the standing HRAng and internal/external range of motion (ROM) in the prone position before THA and 2 weeks after THA. Acetabular/cup and femoral/stem anteversion, combined anteversion (CA), and leg length discrepancy were also characterized. Correlations were examined postoperatively between the HRAng and the other analyzed variables. RESULTS: The median standing HRAng showed a significant internal shift from external to more medial position (6.3° to 1.7°) 2 weeks after THA (P<.0001). The postoperative change in standing HRAng was significantly negatively correlated with the difference between the postoperative femoral anteversion and the stem anteversion (rs=-0.429, P<.0001) and with the pre- to postoperative change in CA (rs=-0.3012, P=.0063). CONCLUSION: This study demonstrated that the extent of the rotational shift of the distal femur toward medial direction was significantly associated with increasing stem anteversion and CA. This phenomenon can be interpreted as a compensatory mechanism for maintaining the relative positional relationship between the pelvis and the proximal femur using proprioception. Therefore, we conclude that the extracapsular/extra-articular components may be prominent determinants of joint position sense. [Orthopedics. 2024;47(3):e114-e118.].
Asunto(s)
Artroplastia de Reemplazo de Cadera , Osteoartritis de la Cadera , Rango del Movimiento Articular , Humanos , Femenino , Masculino , Persona de Mediana Edad , Anciano , Osteoartritis de la Cadera/cirugía , Osteoartritis de la Cadera/fisiopatología , Rotación , Articulación de la Cadera/cirugía , Articulación de la Cadera/fisiopatología , Anciano de 80 o más Años , Adulto , Propiocepción/fisiología , Periodo PosoperatorioRESUMEN
INTRODUCTION: An acetabular liner thickness of around 6 mm remains the "gold standard" in total hip arthroplasty. Some surgeons have been recommending the use of the thickest possible liner because contact stress and strain in articulating surfaces decrease with increasing the wall thickness. The purpose of this study was to determine whether in vivo creep and wear performance could be enhanced using a thicker liner over the standard thickness in vitamin-E-diffused highly crosslinked polyethylene (HXLPE). MATERIALS AND METHODS: One hundred and twenty-two hips were allocated to age-matched, sex-matched, and body mass index-matched two subgroups implanted either with a 6.8- or 8.9-mm-thick vitamin-E-diffused HXLPE liner against 28-mm cobalt-chrome femoral head, and followed-up for 7 years. Linear and volumetric penetration of femoral head into the liners attributed to creep and wear were analyzed for each group. RESULTS: Compressive creep strain generated at the initial 6 months was significantly larger in the 6.8-mm group (2.6%) than in the 8.9-mm group (2.2%). The linear steady-state wear observed after 2 years was 0.0019 and 0.0015 mm/year, whereas the volumetric steady-state wear was 0.54 and 0.45 mm3/years in the 6.8- and 8.9-mm-thick groups, respectively. Although less strain in the thicker group resulted in a slightly less wear, it did not reach significant differences in the steady-state wear rates between the groups. CONCLUSION: No clinical significance for using a thicker liner over the standard thickness (6.8 mm â 8.9 mm) was confirmed in the vitamin-E-diffused HXLPE according to the 7-year follow-up. The wear rates for both thicknesses were very low enough to prevent osteolysis, and no mechanical failure was observed at any follow-up interval. Nevertheless, since the significantly higher strain was seen in the thinner liner, further follow-up is needed to compare the longer term wear and the incidence of osteolysis and component fracture.
Asunto(s)
Artroplastia de Reemplazo de Cadera , Prótesis de Cadera , Osteólisis , Humanos , Niño , Artroplastia de Reemplazo de Cadera/efectos adversos , Polietileno , Vitamina E , Osteólisis/etiología , Falla de Prótesis , Diseño de Prótesis , Prótesis de Cadera/efectos adversos , Vitaminas , Estudios de SeguimientoRESUMEN
BACKGROUND: The aims of this study are as follows: (1) to investigate the level and probability of bacterial contamination on scrub suits over time for medical personnel working inside and/or outside the operating room (OR) area; (2) to discuss the protective role of cover gowns against bacterial contamination; and (3) to consider the necessity of changing into clean suits whenever entering the OR in terms of preventing periprosthetic joint infection (PJI) in total joint replacement (TJR). METHODS: The bacterial colony count was examined on the chest area of the scrub suits worn during various daily clinical practices. The genus/species of the contaminants were identified by matrix-assisted laser deposition ionization-time of flight mass spectrometry (MALDI-TOF MS). RESULTS: The scrub suits worn outside the OR area showed a greater level of bacterial contamination than those worn inside the OR area, although the colony counts tended to increase over time both in and out of the area. The probability of contamination involving coagulase-negative staphylococci (CNS) (known as the primary cause of PJI) did not increase significantly in the scrubs worn inside the OR area, but did increase significantly after a long-time departure from the OR area. CONCLUSIONS: Our results suggest that wearing scrub suits outside and/or the long duration of wearing the same suits can significantly increase the level and probability of any bacterial contamination (including CNS) on scrub suits. We also found that wearing a cover gown over scrub suits outside the OR area may have only a limited protective role against bacterial contamination.
RESUMEN
BACKGROUND: Adverse local tissue reactions have been problematic as an implant-related complication in total hip arthroplasty (THA). Despite the absence of significant metal wear and corrosion, granulomatous pseudotumor has been reported to be caused by polyethylene wear. We performed a long-term follow-up study investigating the relationship between polyethylene wear and pseudotumor formation in THA. METHODS: This study included 57 patients (64 hips) that underwent primary THA with metal-on-polyethylene or ceramic-on-polyethylene bearing over a minimum follow-up of 15 years. They were stratified into pseudotumor and non-pseudotumor groups and their linear wear rates of polyethylene liner and serum cobalt (Co) and chromium (Cr) ion levels were compared. Pseudotumor was diagnosed on metal artifact reduction sequence-MRI according to its composition and wall thickness using the Hauptfleisch classification. RESULTS: The incidence of pseudotumor was 34% (22/64 hips) at the mean follow-up of 16.9 years. Metal ion levels did not differ between the pseudotumor and non-pseudotumor groups, and none of the patients exceeded the Co/Cr ratio of 2.0 µg/L. Moreover, the wear rate in the pseudotumor group was 1.8 times greater than in the non-pseudotumor group (0.14 vs. 0.08 mm/year, P < 0.001). According to an analysis of the receiver operating characteristic curves, the cutoff level of the wear rate to discriminate between pseudotumor and non-pseudotumor patients at 15 years was 0.11 mm/year (area under the curve = 91%; sensitivity = 95%; specificity = 78%; accuracy = 87%). CONCLUSIONS: Our results might provide new insights into excessive polyethylene wear potentially leading to the future development of both pseudotumor and osteolysis. Further studies are needed to clarify the direct relationship between polyethylene wear and pseudotumor and the mutual effects of osteolysis and pseudotumor in particle reactions.
Asunto(s)
Artroplastia de Reemplazo de Cadera , Osteólisis , Humanos , Polietileno/efectos adversos , Artroplastia de Reemplazo de Cadera/efectos adversos , Estudios de Seguimiento , Cerámica , Complicaciones PosoperatoriasRESUMEN
The aim of the present study was to evaluate how much reduction in acetabular liner thickness could be tribologically acceptable in metal-on-vitamin-E diffused highly crosslinked ultra-high molecular weight polyethylene (Vit-E XLPE) bearings for total hip arthroplasty. We tested thick- (10.3 mm), moderate- (6.3 mm), and thin- (4.3 mm) Vit-E XLPE liners coupled with 28-mm cobalt-chromium femoral heads on a hip simulator to 5 million cycles, and peak contact stress was predicted based on mathematical modeling. Wear damage was also evaluated in terms of surface topology and morphology. Wear simulation demonstrated that the 2-4 mm thickness reduction (6.3 â 4.3 mm and 10.3 â 6.3 mm) did not significantly affect the wear rate for Vit-E XLPE liner, whereas 6-mm reduction (10.3 â 4.3 mm) significantly increased liner wear (by 309%) and head roughness (by 415%). This effect was attributed to a contact stress increase (by 24-41%). However, the wear rates for all thicknesses tested were much lower than those previously reported for thicker non-crosslinked materials. The original crystalline morphology was maintained in all liners after wear. Our results suggest that the 2-4 mm thickness reduction may be tribologically acceptable in Vit-E XLPE liners. However, more severe and longer term simulations are necessary to determine a minimum acceptable thickness.
Asunto(s)
Artroplastia de Reemplazo de Cadera , Prótesis de Cadera , Acetábulo , Humanos , Metales , Polietileno/química , Diseño de Prótesis , Falla de Prótesis , Vitamina E/químicaRESUMEN
BACKGROUND: The present study aimed to identify risk factors for preoperative nasal carriage of resistant bacteria - MRSA methicillin-resistant Staphylococcus (S.) aureus, MRSE (methicillin-resistant Staphylococcus epidermidis), and MRCNS (methicillin-resistant coagulase negative staphylococci) in total hip and knee arthroplasty (THA and TKA) patients. METHODS: Nasal cultures were obtained from 538 patients before THA (262 primary and 26 revision) and TKA (241 primary and 9 revision). These were classified either as methicillin-resistant bacteria (group MR) or methicillin-susceptible bacteria (including culture-negative) (group MS). Patient characteristics were compared between these groups using logistic regression models. RESULTS: The resistant bacteria were preoperatively present in 33.1% (178 patients) among all patients. MRSE, MRCNS, and MRSA were detected in 27.5% (148 patients), 3.7% (20 patients), and 1.9% (10 patients). In the unadjusted comparisons of the patient characteristics between the groups MR and MS, a significant difference was found in the percentages of diabetic patients (15.2% vs. 9.2%, P = 0.04); the association remained after the multivariable adjustment for possible risk factors (P < 0.001). In addition, the diabetic patients in the group MR showed a higher percentage of receiving insulin injection than those in the group MS (25.9% vs. 6.1%, P = 0.063), and their mean levels of HbA1c were significantly higher in the group MR than the MS (6.8% vs. 6.4%, P = 0.03). CONCLUSIONS: We identified diabetes as a risk factor for the preoperative nasal carriage of resistant bacteria. Our results suggest that, in order to prevent a surgical site infection (SSI), extra care should be taken in performing joint arthroplasties for diabetic patients, especially using insulin and with high HbA1c levels (≥6.6%) prior to the surgical procedures.
Asunto(s)
Artroplastia de Reemplazo de Cadera , Artroplastia de Reemplazo de Rodilla , Insulinas , Staphylococcus aureus Resistente a Meticilina , Infecciones Estafilocócicas , Antibacterianos/uso terapéutico , Artroplastia de Reemplazo de Rodilla/efectos adversos , Hemoglobina Glucada , Humanos , Meticilina , Resistencia a la Meticilina , Factores de Riesgo , Infecciones Estafilocócicas/tratamiento farmacológico , Staphylococcus aureusRESUMEN
OBJECTIVE: To investigate the long-term survivorship, incidence of adverse reactions to metal debris (ARMD), and metal ion behavior in patients who underwent small-head Metasul metal-on-metal (MoM) total hip arthroplasty (THA). METHODS: Between February 1998 and September 2003, a retrospective study was performed on 43 consecutive patients (43 hips) who underwent unilateral cementless Metasul MoM THAs at our institution. Of them, 35 patients (nine males and 26 females) who were available for follow-up more than 15 years after THA were enrolled in this study and underwent metal artifact reduction sequence magnetic resonance imaging (MARS-MRI) to identify ARMD. The mean age at surgery of the patients was 59.7 years old (range, 31-83). Clinical and radiographic outcomes were evaluated retrospectively. Clinical examinations were conducted using the Harris Hip Score (HHS). Serum cobalt (Co) and chromium (Cr) ion levels and Co/Cr ratio were assessed at different postoperative periods of <5, 5-10, 11-14, and ≥15 years. RESULTS: The mean follow-up period for the 35 patients included was 18.1 years (range, 15-22). The mean HHS significantly improved from 44.6 ± 11.3 points preoperatively to 89.4 ± 7.9 points at the final follow-up (P < 0.0001). ARMD was found in 20% of the patients using MARS-MRI. No signs of stem loosening were found clinically or radiographically, whereas cup loosening and ARMD were observed in three patients (9%), for whom revision THAs were performed. The Kaplan-Meier survival rates with revision for any reason as the endpoint were 90.9% at 5 years, 84.8% at 10 years, 84.8% at 15 years (95% CI, 67.1-93.6), and 70.3% at 20 years (95% CI, 43.6-87.0). The survival rates with revision for ARMD as the endpoint were 100% at 5 years, 96.6% at 10 years, 96.6% at 15 years (95% CI, 77.2-99.7), and 80.1% at 20 years (95% CI, 45.3-95.2). Serum Co ion level peaked at 5-10 years after THA, which was significantly higher than that <5 years; however, it decreased to the initial level after 15 years. In contrast, serum Cr ion level significantly increased at 5-10 years and then remained almost constant. Significant differences in Cr ion levels (1.0 vs 2.0 µg/L, P = 0.024) and Co/Cr ratio (1.3 vs 0.9, P = 0.037) were found between non-ARMD and ARMD patients at >11 years postoperatively. CONCLUSION: Our results suggest that increased Cr ion levels and decreased Co/Cr ratio may be signs of ARMD in patients who underwent small-head Metasul MoM THA.
Asunto(s)
Artroplastia de Reemplazo de Cadera , Prótesis de Cadera , Prótesis Articulares de Metal sobre Metal , Artroplastia de Reemplazo de Cadera/efectos adversos , Artroplastia de Reemplazo de Cadera/métodos , Cobalto , Femenino , Estudios de Seguimiento , Prótesis de Cadera/efectos adversos , Humanos , Masculino , Prótesis Articulares de Metal sobre Metal/efectos adversos , Persona de Mediana Edad , Diseño de Prótesis , Falla de Prótesis , Reoperación , Estudios RetrospectivosRESUMEN
We present a rare case of symptomatic adverse local tissue reaction in a 54-year-old female patient who had undergone total hip arthroplasty with ceramic-on-ceramic bearing. Inflammatory periarticular mass and osteolysis developed in the absence of cobalt chrome alloy interfaces and a modular neck component. On the pathologic images, there was no clear evidence of gross metal staining of tissues, metal corrosion, and ceramic or metal wear particles. However, there were impingement scars on the titanium alloy femoral neck and acetabular cup associated with a high combined anteversion angle of 75° (stem: 40° and cup: 35°), suggesting titanium debris release in vivo. Immunohistochemical staining proved a predominant infiltration of CD4+ T cells and the corresponding IL-17A response to metal. We conclude that neck-rim impingement may lead to the development of adverse local tissue reaction (periarticular mass and osteolysis) due to a metal hypersensitivity with the production of proinflammatory cytokines (IL-17A) by CD4+ T cells even in ceramic-on-ceramic total hip arthroplasty.
RESUMEN
Characteristic features of osteoarthritis (OA) are joint pain and cartilage degeneration. The degeneration is caused by excess induction of matrix metalloproteinases (MMPs) and the pain is caused by nerve growth factor (NGF)-dependent nerve invasion into synovial tissue in addition to nociceptive pain by prostaglandin (PG)E2. The objective of this study was to clarify the suppressive mechanism of PGE2 on the regulation of MMPs and NGF by focusing on mitogen-activated protein kinases (MAPKs) and their endogenous phosphatase, dual-specificity phosphatase (DUSP)-1 in human synovial fibroblasts. PGE2 strongly increased DUSP-1 and suppressed IL-1ß-induced MAPKs phosphorylation. Inhibition of MAPKs by selective inhibitors differentially regulated the IL-1ß-induced expression of MMPs and NGF expression. IL-1ß-induced MAPKs phosphorylation was prolonged and enhanced in DUSP-1 knockdown cells and the expression of MMPs and NGF was also increased. This study revealed that PGE2 has novel biological activity that suppresses NGF and MMPs expression by inducing DUSP-1 expression.
Asunto(s)
Interleucina-1betaRESUMEN
BACKGROUND: Gradual compression stocking (GCS) and intermittent pneumatic compression device (IPCD) are used for intraoperative mechanical prophylaxis against venous thromboembolism (VTE) during total knee arthroplasty (TKA). In this study, we applied a passive-assisted ankle motion in combination with GCS and IPCD during TKA and evaluated its effectiveness in preventing postoperative VTE. METHODS: We included 77 patients who underwent primary unilateral TKA. Patients were divided into group A (53 patients who underwent GCS and IPCD on their non-surgical side limb) and group B (24 patients who underwent passive ankle dorsiflexion motion in addition to GCS and IPCD on their non-surgical side limb). Deep vein thrombosis (DVT) was assessed using lower extremity ultrasonography (US). The incidence of VTE in each affected limb was compared between the two groups. RESULTS: US was performed 4 days after surgery on average. The incidence of DVT in groups A and B was 47.2 and 70.8 %, respectively. In group A, 22.6 % of DVTs were found only on the surgical side, 11.3 % on the non-surgical side, and 13.2 % on both sides. On the other hand, in group B, 41.7 % of DVTs were found only on the surgical side, 4.2 % on the non-surgical side, and 25.0 % on both sides. No significant difference in the incidence of VTE was noted between the 2 groups. CONCLUSIONS: The intraoperative application of passive ankle motion plus GCS and IPCD might not further reduce the incidence of postoperative DVT in TKA patients.
RESUMEN
BACKGROUND: In view of preventing surgical site infection (SSI) in the orthopedic operating room (OR), evidence concerning types of footwear and clothing is limited. This study aimed to investigate how different footwear and clothing affect the cleanliness of the OR environment. METHODS: The airborne dust concentration in a bioclean room (NASA class 100) was measured around an operator by using a handheld particle counter under the following conditions: (I) wearing a sterilized full-type space suit with OR dedicated clean sandals; (II) wearing a sterilized full-type space suit with non-dedicated (outside) shoes or severely contaminated outside shoes with surgical glove powder (2 µm mean particle size); and (III) wearing an unsterilized medical scrub uniform with OR dedicated sandals. The participant was standing still or stepping in place at 1 Hz during the testing. RESULTS: The concentrations of airborne dusts in the operative field were independent of footwear and clothing types under the stand-still condition. However, these values significantly increased 1.96- to 16.23-fold after simple stepping motion in all the test conditions, and often became dissatisfaction level with the NASA100 requirement for the OR cleanliness. The worst contamination occurred when an operator wore the powder-contaminated shoes and also the unsterilized scrub uniform. CONCLUSION: The present study showed that the stepping motion triggered a considerable contamination in the operative field (beyond the level of NASA100 threshold) particularly when an operator used the outside shoes or unsterilized scrub uniform. Therefore, these results tell us that the one-footwear system (i.e., no use of OR dedicated clean shoes) and unsterilized scrub are likely to be a potential risk factor for SSI. Nevertheless, further studies are necessary to conclude the real efficacy of OR dedicated shoes and sterilized clothes on the SSI prevention.
Asunto(s)
Quirófanos/provisión & distribución , Zapatos , Posición de Pie , Infección de la Herida Quirúrgica/prevención & control , Humanos , Periodo Intraoperatorio , Factores de RiesgoRESUMEN
We describe 2 cases of pseudotumors induced by an unusual size of polyethylene wear particle after metal-on-polyethylene total hip arthroplasty (MoP THA). The supra-macroparticles of size >100 µm originated from a polyethylene liner with relatively small cup anteversion, potentially leading to excessive loading and increased wear of the anterior edge of the polyethylene liner. Histopathology showed a foreign-body reaction to the polyethylene particles without an adverse reaction to metal debris and with no severe signs of corrosion at the head-neck junction, which have been noted in past reports of pseudotumors in MoP THA. It has been suggested that the large polyethylene wear particles might be the cause of pseudotumor formation in MoP THA.
RESUMEN
The purpose of the present study was to compare the wear behavior of ceramic-on-vitamin-E-diffused crosslinked polyethylene (Vit-E XLPE) hip bearings employing the gold standard oxide ceramic, zirconia (ZrO2)-toughened alumina (Al2O3) (ZTA, BIOLOX®delta) and a new non-oxide ceramic, silicon nitride (Si3N4, MC2®). In vitro wear test was performed using a 12-station hip joint simulator. The test was carried out by applying the kinematic inputs and outputs as recommended by ISO 14242-1:2012. Vitamin-E-diffused crosslinked polyethylene (Vit-E XLPE) acetabular liners (E1®) were coupled with Ø28-mm ZTA and Si3N4 femoral heads. XLPE liner weight loss over 5 million cycles (Mc) of testing was compared between the two different bearing couples. Surface topography, phase contents, and residual stresses were analyzed by contact profilometer and Raman microspectroscopy. Vit-E XLPE liners coupled with Si3N4 heads produced slightly lower wear rates than identical liners with ZTA heads. The mean wear rates (corrected for fluid absorption) of liners coupled with ZTA and Si3N4 heads were 0.53 ± 0.24 and 0.49 ± 0.23 mg/Mc after 5 Mc of simulated gait, respectively. However, after wear testing, the ZTA heads retained a smoother topography and showed fewer surface stresses than the Si3N4 ones. Note that no statistically significant differences were found in the above comparisons. This study suggests that the tribochemically formed soft silica layer on the Si3N4 heads may have reduced friction and slightly lowered the wear of the Vit-E XLPE liners. Considering also that the toughness of Si3N4 is superior to ZTA, the present wear data represent positive news in the future development of long-lasting hip components.
RESUMEN
BACKGROUND: Accelerated hydrothermal aging has long been one of the most widely accepted quality control tests for simulating low-temperature degradation (LTD) in zirconia-containing implants used in total hip arthroplasty (THA). However, it is still unclear how much consistency there is between the experimental prediction from the internationally-standardized tests and the actual measurements from surgically-removed implants after a long period of implantation. This question is fundamentally related to a lack of understanding of mechanical/tribological contribution to the in-vivo LTD kinetics. OBJECTIVE: The main purpose of this study is to validate the clinical relevance of standardized accelerated aging by comparing artificially-aged and in-vivo used prostheses, and to clarify the long-term effects of in-vivo mechanics/tribology on the LTD progression upon service in the body environment. METHODS: Surface magnitudes of phase transformation and residual stress in zirconia femoral head retrievals (13.1-18.4 yrs) were evaluated by using confocal Raman microspectroscopy. RESULTS: The long-term aging behavior in unworn head surface was in agreement with the experimental prediction estimated as 1 h aging at 134 °C = 4 years in-vivo. However, the current aging protocols based on ASTM and ISO criteria were not accurately predictive for the worn surfaces, and the tribologically-induced phase transformation and tensile stress were up to 6.5-times and 3.3-times higher than the environmentally-induced ones. CONCLUSION: Our study suggests that wear/scratching, frictional heating, tribochemical reactions, and metal transfer may become far more intense triggers to phase transformation than the mere exposure to body fluid.
Asunto(s)
Análisis de Falla de Equipo/métodos , Prótesis de Cadera , Circonio/química , Aceleración , Envejecimiento/fisiología , Artroplastia de Reemplazo de Cadera/instrumentación , Cerámica/química , Remoción de Dispositivos , Femenino , Cabeza Femoral/patología , Cabeza Femoral/cirugía , Fricción , Prótesis de Cadera/normas , Humanos , Cinética , Ensayo de Materiales/métodos , Persona de Mediana Edad , Reoperación/instrumentación , Reoperación/métodos , Propiedades de Superficie , Factores de TiempoRESUMEN
BACKGROUND: It is important to understand postoperative global sagittal spinal alignment after total hip arthroplasty (THA) to prevent not only the following hip complications but also progressing lumbar degeneration. The purpose of this study was to progress the analysis of the global sagittal spinal alignment between before and after THA in patients without large lower limbs discrepancy. SUBJECTS AND METHODS: The subjects were 87 patients with bilateral hip osteoarthritis (OA) before unilateral primary THA. We measured sagittal vertical axis (SVA), lumbar lordotic angle, sacral slope, pelvic tilt (PT), and pelvic incidence (PI) and compared the postoperative change of those parameters. Excluded criteria were Crowe classification types II, III, and IV and more than 10 mm of leg length difference, spinal scoliosis (Cobb angle > 25°), and lumbar kyphosis. RESULTS: The correlation coefficient between preoperative factors and postoperative sagittal alignments revealed that postoperative SVA has correlation with age (r = 0.46, p < 0.008) and preoperative PT (r = 0.42, p = 0.015). Postoperative PT had a correlation with preoperative PI (r = 0.46, p = 0.007). The change of PT after operation had negative correlation to preoperative PT (r = -0.47, p < 0.01) and PI (r = -0.38, p = 0.03). Multiple regression analysis revealed that the change of PT = 4.979 - 0.235 × preoperative PT (p < 0.05). Therefore, when preoperative PT was less than 20°, the postoperative PT would become larger than the preoperative one. CONCLUSION: (1) In patient with hip OA without large lower limbs discrepancy, the postoperative PT after THA correlated with PI. (2) The postoperative change of PT was influenced by preoperative PT.
Asunto(s)
Artroplastia de Reemplazo de Cadera/métodos , Osteoartritis de la Cadera/cirugía , Postura/fisiología , Anciano , Femenino , Humanos , Masculino , Osteoartritis de la Cadera/fisiopatología , Periodo PosoperatorioRESUMEN
Zirconia-toughened alumina (ZTA) currently represents the bioceramic gold standard for load-bearing components in artificial hip joints. ZTA is long known for its high flexural strength and fracture toughness, both properties arising from a microscopic crack-tip shielding mechanism due to the stress-induced tetragonal-to-monoclinic (tâm) polymorphic transformation of zirconia. However, there have been concerns over the years regarding the long-term structural performance of ZTA since the tâm transformation also spontaneously occurs at the material's surface under low-temperature environmental conditions with a concomitant degradation of mechanical properties. Spontaneous surface degradation has been extensively studied in vitro, but predictive algorithms have underestimated the extent of in vivo degradation observed in retrievals. The present research focused on burst-strength assessments of Ø28 mm ZTA femoral before and after long-term in vitro hydrothermal ageing according to ISO 7206-10. An average burst strength of 52 kN was measured for pristine femoral heads. This value was ~36% lower than results obtained under the same standard conditions by other authors. A further loss of burst strength (~13% in ultimate load) was observed after hydrothermal ageing, with increased surface monoclinic content ranging from ~6% to >50%. Nevertheless, the repetitively stressed and hydrothermally treated ZTA heads exceeded the minimum burst strength stipulated by the US Food and Drug Administration (FDA) despite severe test conditions. Lastly, Raman spectroscopic assessments of phase transformation and residual stresses on the fracture surface of the femoral heads were used to clarify burst-strength fluctuations and the effect of hydrothermal ageing on the material's overall strength degradation.
RESUMEN
Highly cross-linked, ultrahigh molecular weight polyethylene (HXLPE) acetabular liners are inherently associated to a risk of fatigue failure due to femoral neck impingement. Different thicknesses and designs employed with HXLPE liners greatly affect mechanical loading scenario. The purpose of this study was to clarify the influence of liner offset (lateralization) and locking mechanism (presence/absence of anti-rotation tabs in the external surface) on fatigue durability in annealed and vitamin E-blended HXLPE liners with a current commercial design. Each liner tested had six anti-rotation tabs, which were engaged in the 6 of 12 recesses on the metal shell. The remaining six recesses had no direct contact with the liner, where HXLPE was mechanically unsupported by the metal backing. These mated and/or unmated rim regions in the offset (2, 3, 4-mm lateralized) liners were exposed to severe neck impingement until crack propagation was identified. Phase volume percentages (crystalline, amorphous, and intermediate phase contents) of HXLPE liners were compared before and after impingement in order to interpret differences in impingement micromechanics associated with the rim design variations. Our results showed that the presence of unmated recesses served as a stress concentrator due to the formation of millimeter-scale gaps between the liner and shell. Another potential design problem drawn from our study was liner offset associated with a small volume protruding above the metal rim. Therefore, surgeons should take special care in selecting locking designs and geometries especially when using HXLPE offset liners.
Asunto(s)
Acetábulo/cirugía , Materiales Biocompatibles/química , Materiales Biocompatibles/metabolismo , Polietilenos/química , Polietilenos/metabolismo , Artroplastia de Reemplazo de Cadera , Reactivos de Enlaces Cruzados/química , Prótesis de Cadera , Humanos , Fenómenos Mecánicos , Metales/química , Diseño de Prótesis , Falla de Prótesis , Espectrometría Raman , Vitamina E/químicaRESUMEN
Anterior cruciate ligament (ACL) plays an essential role in knee joint stability and kinematics. The microstructural irregularities such as cellular changes and disorganization of the extracellular matrix (ECM) alter the mechanical properties of the ligament, leading to a significant knee functional instability and progression of osteoarthritis (OA). So far, the identification of the local abnormality in ACL has routinely relied on invasive analytical techniques such as histology or biochemical assays. The non-invasive diagnosis using magnetic resonance imaging (MRI) is still limited to identifying the presence/absence of partial/complete ruptures and mucoid degeneration. In this study, laser micro-Raman spectroscopy with near-infrared excitation (785â¯nm) was applied to human ACL in order to establish optical algorithms for non-destructively diagnosing a degeneration state at molecular level. Raman spectra were obtained from 44 ex-vivo ACL specimens, and these were subsequently classified as an early (subclinical) and advanced (clinical) level of tissue degradation based on the histopathological scoring system. The significant differences in Raman peak intensities were found between the different degeneration groups, which were assigned to the vibrational modes of nucleic acids in cells, collagens, and phospholipids. Linear discriminant analysis (LDA) was performed to identify cut-off values for the distributions of Raman intensity and intensity ratios, which enable to best discriminate between the early and advanced degenerated tissues. Raman intensity algorithms derived from I1101/I1749, [I1002/I1516vs. I1101/I1749], and [I1002/I1749vs. I1101/I1749], yielded a maximum diagnostic sensitivity of 100%, specificity of 80%, and accuracy of 91% for discriminating the degeneration severity. STATEMENT OF SIGNIFICANCE: In this study, laser micro-Raman spectroscopy was applied to human anterior cruciate ligament (ACL) to establish optical algorithms for non-destructively diagnosing the tissue degeneration at molecular level. To our knowledge, this is the first report on Raman diagnosis for human ACL. Linear discriminant analysis (LDA) was performed to identify cut-off values for Raman intensity and intensity ratios, which enable to best discriminate between an early (subclinical) and advanced (clinical) level of ACL degeneration. The intensity ratios of I1101/I1749, [I1002/I1516vs. I1101/I1749], and [I1002/I1749vs. I1101/I1749] yielded a maximum diagnostic sensitivity of 100%, specificity of 80%, and accuracy of 91% for discriminating the ACL degeneration. The present findings might contribute to expanding clinical diagnostic possibilities for non-invasively identifying tissue degeneration.
Asunto(s)
Ligamento Cruzado Anterior/anomalías , Rodilla/anatomía & histología , Espectrometría Raman/métodos , Adolescente , Adulto , Anciano , Algoritmos , Lesiones del Ligamento Cruzado Anterior/fisiopatología , Reconstrucción del Ligamento Cruzado Anterior , Artroplastia de Reemplazo de Rodilla , Fenómenos Biomecánicos , Colágeno/metabolismo , Diagnóstico por Computador , Análisis Discriminante , Matriz Extracelular/metabolismo , Femenino , Humanos , Rodilla/fisiopatología , Modelos Lineales , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Osteoartritis/fisiopatología , Osteoartritis de la Rodilla/fisiopatología , Fosfolípidos/metabolismo , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Espectroscopía Infrarroja Corta/métodos , Adulto JovenRESUMEN
PURPOSE: The purpose of the present study was to follow up Japanese patients with deep vein thrombosis (DVT) after total knee arthroplasty (TKA) and also to examine factors associated with residual thrombus within the sixth postoperative month. METHODS: DVT evaluation was performed by noninvasive venous ultrasonography. We retrospectively reviewed 88 Japanese patients (88 knees) receiving primary unilateral TKA, who had no preoperative DVT. We examined the influence of the following four factors on postoperative DVT: (1) patient factors (age, sex, body height, body weight, and body mass index), (2) surgical factors (operation time, bleeding amount, avascularization time, and anesthesia method), (3) postoperative factors (bleeding amount, period to ambulation, period of venous foot pump use, and ratio of graduated compression stocking use), and (4) DVT conditional factors (location, length, number of vein branches, and the presence of >5 mm vasodilatation). RESULTS: The total prevalence of venous thromboembolism (VTE) was 62.5% (55 of the 88 patients). Among the 55 VTE patients, the rates of distal and proximal DVT were 96.4% and 3.6%, respectively. Bilateral DVT was found in 34.5%, while unilateral DVT on the surgical and nonsurgical sides were 52.7% and 12.7%, respectively. Asymptomatic pulmonary embolism was 1.8%. DVT was exacerbated in five patients (11.9%), of whom three showed additional thrombus formation. The remaining two patients had thrombus elongation or propagation from distal to proximal veins. In comparisons between thrombus-unresolved and -resolved groups within the sixth postoperative month, statistical significances were found in the incidence of bilateral DVT (50.0% vs. 15.4%, p = 0.02) and unilateral DVT (43.8% vs. 76.9%, p = 0.02). On the other hand, operation time (107.0 ± 17.3 min vs. 94.5 ± 11.9 min, p = 0.01) and avascularization time (99.8 ± 17.6 min vs. 88.0 ± 11.5 min, p = 0.01) in bilateral DVT patients were significantly longer than in unilateral ones. CONCLUSION: Our results suggest that an extended operation and avascularization time may be a risk factor for bilateral DVT and residual thrombus over 6 months.
Asunto(s)
Artroplastia de Reemplazo de Rodilla/efectos adversos , Complicaciones Posoperatorias/etiología , Ultrasonografía/métodos , Trombosis de la Vena/etiología , Anciano , Anciano de 80 o más Años , Enfermedades Asintomáticas , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Japón/epidemiología , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/epidemiología , Prevalencia , Estudios Retrospectivos , Factores de Riesgo , Factores de Tiempo , Trombosis de la Vena/diagnóstico , Trombosis de la Vena/epidemiologíaRESUMEN
The acetabular liner malalignment and rim impingement have been problematic issues in ceramic-on-ceramic (CoC) total hip arthroplasty (THA). Commercial ceramic liners made of alumina-matrix composite (AMC) have polished articulation and rim, and roughly ground backside with a button-like apical projection (post) to resist tilting. In this study, we hypothesized that rim cracks and backside grind critically affect the aging kinetics of tetragonal zirconia dispersed in AMC structure. We analyzed phase transformation in the zirconia phase and residual stresses in the alumina matrix during aging by Raman and fluorescence spectroscopy. We demonstrated that the polished surfaces showed environmental stability in vitro, while the roughly-ground backside showed a significant stability loss and tensile stress accumulation as a consequence of enhancing the inter-component fixation between the liner and the metallic shell. Rim cracking locally produced a preferential transformation at the tip and the surrounding of the crack. Note that the tensile stress concentration at the crack tip was counteracted by the phase transformation after a few hours of aging. This suggests the presence of a time lag in vivo before further transformation around the crack could provide a crack shielding effect in the material. © 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part B, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 791-798, 2019.