RESUMEN
In this review the data on the presence of associations between immunogenetic markers and the development of HIV infection are presented. Special attention is given to spatial relationships of genetic determinants, responsible for the synthesis of the components of the complement system on one hand and the genes controlling resistance to the causative agents of opportunistic infections and malignant growth on the other hand. Suggestion is made on close relationship between the specific features of the course of HIV infection and the genetic control, responsible for the synthesis of complement components, in particular the genes making up the HLA system.
Asunto(s)
Infecciones por VIH/etiología , VIH-1 , Proteínas del Sistema Complemento/genética , Proteínas del Sistema Complemento/inmunología , Infecciones por VIH/genética , Infecciones por VIH/inmunología , Antígenos HLA/genética , Antígenos HLA/inmunología , Humanos , Inmunogenética , Complejo Mayor de Histocompatibilidad/genética , Complejo Mayor de Histocompatibilidad/inmunologíaAsunto(s)
Vía Alternativa del Complemento/inmunología , Infecciones por VIH/inmunología , VIH-1 , Infecciones Oportunistas Relacionadas con el SIDA/etiología , Infecciones Oportunistas Relacionadas con el SIDA/genética , Infecciones Oportunistas Relacionadas con el SIDA/inmunología , Autoinmunidad , Vía Alternativa del Complemento/genética , Infecciones por VIH/genética , Infecciones por VIH/terapia , Antígenos HLA-DR/genética , Antígenos HLA-DR/inmunología , Humanos , Resultado del Tratamiento , Cromosoma X/genéticaRESUMEN
A model is proposed and well based of structure of the receptor apparatus of interacting HIV target cells: Langerhans cells (LC) and helper cells (HC)--designed to explain feasibility of realizing a double activation signal, together with some features of immune pathogenesis of HIV-infection (morphofunctional abnormalities in certain subpopulations of the immune system such as HC, suppressor cells, killer cells, natural killers, lymph cells, macrophages, LC), as well as immunogenetic predisposition to AIDS.