[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].

Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied. The effect of selank (30 patients) was compared to that of medazepam (32 patients). Patient's state was assessed with psychometric scales (Hamilton, Zung, CGI). Enkephalin activity in the blood serum was measured as well. The anxiolytic effects of both drugs were similar but selank had also antiasthenic and psychostimulant effects. The clinical-biological study revealed that patients with GAD and neurasthenia had the decreased level of tau(1/2) leu-enkephalin which was correlated with disease duration, severity of symptoms related to anxiety and asthenia and autonomic disorders. The increase of this parameter and stronger positive correlations with anxiety level were observed during the treatment with selank mostly in patients with GAD.

[Activities of the day-care geriatric psychiatric hospital within the structure of the regional psycho-neurological hospital]. / Deiatel'nost' dnevnogo gerontopsikhiatricheskogo statsionara v strukture raionnogo psikhonevrologicheskogo dispansera.

The authors analyze activities of the daytime gerontopsychiatric hospital as a new organizational form within the structure of the district psychoneurological dispensary. During 12 months, 70 patients were treated at the hospital. The demographic, nosological and syndromological characteristics of the patients are provided. A range of the clinical indications were determined for referral to the specialized semi-hospital with regard to the mental status, somatic pathology and social status of the patients.