Nosocomial hepatitis C virus transmission from tampering with injectable anesthetic opioids.

UNLABELLED: The extent of provider-to-patient hepatitis C virus (HCV) transmission from diversion, self-injection, and substitution ("tampering") of anesthetic opioids is unknown. To quantify the contribution of opioid tampering to nosocomial HCV outbreaks, data from health care-related HCV outbreaks occurring in developed countries from 1990 to 2012 were collated, grouped, and compared. Tampering was associated with 17% (8 of 46) of outbreaks, but 53% (438 of 833) of cases. Of the tampering outbreaks, six (75%) involved fentanyl, five (63%) occurred in the United States, and one each in Australia, Israel, and Spain. Case counts ranged from 5 to 275 in the tampering outbreaks (mean, 54.8; median, 25), and 1-99 in the nontampering outbreaks (mean, 10.4; median, 5); between them, the difference in mean ranks of counts was significant (P < 0.01). To estimate HCV transmission risks from tampering, risk-assessment models were constructed, and these risks compared with those from surgery. HCV transmission risk from exposure to an opioid preparation tampered by a provider of unknown HCV infection status who is a person who injects drugs (PWID; 0.62%; standard error [SE] = 0.38%) exceeds 16,757 times the risk from surgery by a surgeon of unknown HCV infection status (0.000037%; SE = 0.000029%) and 135 times by an HCV-infected surgeon (0.0046%; SE = 0.0033%). To pose a 50% patient transmission risk, an infected surgeon may take 30 years, compared to <1 year for a PWID tamperer, and weeks or days for a PWID tamperer who intensifies access to opioids. CONCLUSION: Disproportionately, many cases of HCV infection from nosocomial outbreaks were attributable to provider tampering of anesthetic opioids. Transmission risk from tampering is substantially higher than from surgery.

Observational study of Mallampati changes after prone spinal surgery.

STUDY OBJECTIVE: To evaluate airway changes in patients undergoing surgery in the prone position. DESIGN: Single-arm observational study. PATIENTS: Patients between 18 to 65 years old, scheduled for prone spinal surgery; 74 patients were enrolled and 54 patients were analyzed. INTERVENTION: The initial airway examination was graded according to the Samsoon and Young modification of the Mallampati classification (MMP). Airway photographs were obtained in a standardized manner and were repeated 20 minutes after extubation. The photographs were then randomized. MEASUREMENTS: Subjects' age, gender, race, weight, duration of surgery, amount of crystalloid fluid given, and estimated blood loss were recorded. Three senior anesthesiologists who were blinded to the origin of the photographs analyzed and graded the airways. MAIN RESULTS: All statistical tests showed significance between pre-MMP and post-MMP scores (P<0.001). There was no difference between pre and post interobserver MMP scores. The MMPs of 12 patients (22%) did not change and MMP scores were changed in 42 patients (78%): 30 (71%) patients by one class, 10 (24%) patients by two classes, and two patients (5%) by three classes. There was no correlation between patients whose MMP was changed and length of surgery or crystalloid administered. CONCLUSION: Modified Mallampati scores increased in the majority of patients after spinal surgery in the prone position.