[Interrelation of changes in the levels of calcium, calmodulin and cyclic nucleotides in children with ectopic types of arrhythmia]. / Vzaimosviaz' izmenenii soderzhaniia kal'tsiia, kal'modulina i tsiklicheskikh nukleotidov pri ektopicheskikh vidakh aritmii u detei.

In 61 children with different patterns of ectopic arrhythmias (premature heart beat, paroxysmal and non-paroxysmal tachycardia), the peripheral blood leukocytes and myocardial tissues were examined for the content of calmodulin (CM), ionized calcium (Ca2+) and cyclic nucleotides (CN). The data obtained indicate that the CM-Ca2+ and CN system are involved in the genesis of arrhythmias in children and may be used as additional criteria in the diagnosis of cardiac rhythm abnormalities.

[Characteristics of phenotype in children with arrhythmia]. / Osobennosti fenotipa u detei s aritmiiami.

Examination of 200 children suffering from arrhythmias made it possible to define specific features of the phenotype, attesting to the pathogenetic relation to the condition of the body connective tissue. The authors describe combinations of the signs for the selection of persons at risk for arrhythmias and mitral valve prolapse.

[Clinical significance of cyclic nucleotide metabolism and calcium level in children with arrhythmia]. / Klinicheskoe znachenie osobennostei obmena tsiklicheskikh nukleotidov i soderzhaniia ka'ltsiia pri aritmiiakh serdtsa u detei.

The cyclic nucleotides (CN) system and Ca2+ content were examined in children with various heart rhythm disorders (HRD). Marked changes were demonstrated which correlated to clinical manifestations of the arrhythmias: their type, phase, duration and favorable changes in their course. Antiarrhythmic therapy was associated with a normalization of the altered levels of cyclase components and Ca2+. The results suggest that intracellular metabolism regulation may be disrupted in HRD cases and play an important role in the development of arrhythmias.

[Effect of phentolamine on the clinical manifestations of the disease and hemodynamics in children with 2d- and 3d-degree atrioventricular block]. / Vliianie fentolamina na klinicheskie proiavleniia zabolevaniia i gemodinamiku pri atrioventrikuliarnoi blokade II i III stepeni u detei.

Phentolamine has been shown to improve peripheral hemodynamics and have a favorable central hemodynamic effect, reflected in clinical improvement, in children with bradycardia (11 patients with second- or third-degree atrioventricular block) and signs of circulatory insufficiency.

[Cyclic nucleotides and creatine phosphokinase activity in children with cardiac arrhythmias]. / Tsiklicheskie nukleotidy i aktivnost' kreatinfosfokinazy u detei s narusheniiami ritma serdtsa.

Forty-one children with cardiac arrhythmias were examined. It was established that cardiac rhythm disorders in children were accompanied by an increase in the cGMP levels as well as a decrease in the cAMP content, CPK activity and the cAMP/cGMP ratio varying in relation to the form of arrhythmia and the nature of heart damage.