Efficacy and Safety of Antibiotic Impregnated Microporous Nanohydroxyapatite Beads for Chronic Osteomyelitis Treatment: A Multicenter, Open-Label, Prospective Cohort Study.

Chronic osteomyelitis is still a serious health problem that causes disabling conditions and has an impact on the quality of life. The objective of this study was to determine the clinical efficacy and safety of localized antibiotics delivery via impregnated microporous nanohydroxyapatite (nHA-ATB) beads for chronic osteomyelitis treatment. A total of 62 patients were enrolled in this study. After radical surgical debridement, the bone defect was filled with three types of antibiotics (vancomycin or gentamicin or fosfomycin) impregnated HA beads. The follow-up period was 48 weeks. It was found that the success rate was approximately 98% with a re-infection in only one patient. Quality of life of all patients after treatment improved significantly over time. Systemic exposure to vancomycin and gentamicin after beads implantation was limited and high local antibiotics concentrations were found in wound drainage fluid at 24, 48 and 72 h. Blood biochemistry measurements did not show any nephrotoxic or hepatotoxic effects. 20 adverse events were reported, but 90% of the events were resolved without having to remove the beads and the patients recovered. Satisfactory outcomes were observed in terms of success rate, quality of life and adverse effect. nHA-ATB beads impregnated by vancomycin or gentamicin or fosfomycin could potentially be employed as an alternative product of choice for localized antibiotics delivery in chronic osteomyelitis treatment.

Abnormally Prolonged Bleeding After an Arthroscopic Knee Reconstruction Because of an Inherited Factor XIII Deficiency: A Case Report.

CASE: An 18-year-old man developed ecchymosis after arthroscopic anterior cruciate ligament reconstruction with semitendinosus graft and meniscal repair. The results of routine coagulation studies were normal, but factor assays showed a reduction in factor XIII levels. The bleeding symptoms were dramatically improved after administration of cryoprecipitate. CONCLUSION: Factor XIII deficiency is one of the rare clotting factor deficiencies that can be present at birth or be manifested later in life. Clinical awareness of factor XIII deficiency is essential so that appropriate testing and treatment can be achieved.

Analgesic efficacy of a single-dose, intraoperative, intra-articular morphine application in ACL reconstruction.

BACKGROUND: Anterior cruciate ligament (ACL) reconstruction is the mainstay treatment for the symptomatic anterior cruciate ligament insufficiency. Postoperative rehabilitation is the key main factor in successful surgical outcome but, the postoperative pain is a major obstacle to achieve good postoperative rehabilitation. The purpose of this study is to compare the effects of intra-articular morphine (IAMO) with normal saline [control group (C)] for postoperative pain control in the ACL reconstruction knees. METHODS: Patients who underwent ACL reconstruction during 2017-2019 were included, prospectively, from Khon Kaen hospital and randomized into 2 groups: IAMO group and the control group (C). After surgery, all patients received the same rehabilitation protocols. The results were assessed using the visual analogue scale (VAS), following the spinal block anesthesia at 6, 12,18 and 24 hours. Time to first analgesic request, range of motion and adverse effects were recorded. RESULTS: Forty patients were included and twenty were designated to the IAMO group. The mean age was 25.3±7.6 years and 80 percent of the patients were males. The IAMO group had lower VAS scores at the 12 and 24 hour postoperative periods [greatest variance at 12 hours (4.7±1.7 vs 5.8±1.6)]. In the IAMO group, time to first analgesic request was longer and morphine consumption was less, but these were not statistically significant. No complications were observed in both groups. CONCLUSIONS: The trend of VAS in the IAMO group was lower than in the control group, especially at 12 hours after surgery with no statistically significant differences. From this study and with the advantages of IAMO after ACL reconstruction, IAMO is useful in ACL reconstruction patients without complications.

The acromion in supraspinatus outlet and Rockwood caudal tilt views from three-dimensional computed tomography scan of the shoulder.

BACKGROUND: A hooked acromion on an outlet view and a keeled acromion on Rockwood tilt radiographs are associated with rotator cuff tears. The identification of the acromial morphology may be helpful for acromioplasty planning with regarding the acromial types. METHODS: Descriptive Laboratory Study. Three-dimensional computed tomography scans models of 108 shoulders in 91 patients with; (1) Normal shoulders, (2) Shoulders with osteoarthritis, and (3) Irreparable rotator cuff tears; were created and adjusted manually to provide the proper supraspinatus outlet and Rockwood views. The acromial morphology/spurs were analyzed, classified and tested for reliability. RESULTS: The intra-observer reliability of supraspinatus outlet view had a weak-to-strong agreement [0.828 (95%CI: 0.716-0.945, p-value<0.001), and 0.475 (95%CI: 0.288-0.672, p-value<0.001 from 2 evaluators]. The inter-rater of the supraspinatus outlet view has a minimal-to-moderate agreement [0.782 (95%CI: 0.662-0.907, p-value<0.001), and 0.344 (95%CI: 0.157-0.539, p-value<0.001) in the first and second readings]. The intra-observer reliability of the Rockwood view has a moderate-to-almost-perfect agreement [0.752 (95%CI: 0.652-0.860, p-value<0.001), and 0.903 (95%CI: 0.833-0.974, p-value<0.001) from 2 evaluators]. The inter-observer reliability of the Rockwood view has a moderate-to-strong agreement [0.854 (95%CI: 0.777-0.936, p-value<0.001), and 0.737 (95%CI: 0.634-0.847, p-value<0.001) in the first and second readings]. CONCLUSION: The classification of acromion morphology under Three-dimensional computed tomography in the supraspinatus outlet view has poor reliability. The Rockwood caudal tilt view model results in moderate-to-almost-perfect reliability that can be developed to the plain radiographic classification to determine the need for acromioplasty in rotator cuff surgery.

Accuracy comparisons of intra-articular knee injection between the new modified anterolateral Approach and superolateral approach in patients with symptomatic knee osteoarthritis without effusion.

BACKGROUND: Intra-articular knee injection with steroid or various other agents have been used to control the local inflammation and relieve pain in the osteoarthritis knee. To achieve the maximal potential therapeutic worth and decrease the complications from the inaccurate knee injection, these medications should be delivered directly into the intra-articular space. Injection technique is one of the most important factors for accuracy of knee injection. Therefore, this study was aimed to propose the new modified anterolateral injection technique for higher accuracy of knee injection in symptomatic osteoarthritis knee without effusion. MATERIAL AND METHODS: Patients with symptomatic osteoarthritis without effusion were included prospectively from May 2014 to May 2015 and randomized into 2 groups for knee injection: Modified anterolateral (MAL), Standard superolateral (SL). Knee injection was performed by one experienced orthopaedic. Accuracy of injection was test by mini air-arthrography technique. The pain from injection were evaluated by visual analog scale (VAS). RESULT: 132 knees were included, 66 knees were modified anterolateral group same as superolateral group. The modified anterolateral injection was significantly yield the higher accuracy rate than the standard superolateral injection (89% vs 58%, P < 0.05). The pain visual analog scale was not significantly different between the modified anterolateral and standard superolateral injection technique (2.61 vs 2.65, P = 0.917) No adverse events were occurred. CONCLUSION: The new modified anterolateral injection yields the higher pooled accuracy rate. From the accuracy and the advantage of the new modified anterolateral injection, this is the preferred injection technique for the symptomatic osteoarthritis without knee effusion.

Preoperative planning of medial opening wedge high tibial osteotomy using 3D computer-aided design weight-bearing simulated guidance: Technique and preliminary result.

BACKGROUND: High tibial osteotomy (HTO) is an established treatment for uni-compartmental osteoarthritis with varus deformity in relatively active young patients with good knee mobility. The most important factor for success and low complications of HTO is the precise correction of osteotomy. The objective of this study was to evaluate the accuracy of pre-operative planning of open-wedge HTO using t3D computer-aided design (CAD) weight-bearing simulated guidance technique for the succession of surgery. MATERIALS AND METHODS: Nineteen patients who met the inclusion criteria were recruited between July 2013 and June 2014. 3D CAD weight-bearing simulated guidance technique was obtained from standard anterior-posterior, lateral of hip-to-ankle full leg standing radiographs, and computed tomography (CT) scan provided the weight-bearing corrective axis of preoperative planning and predictive corrective mechanical axis value. Post-operative mechanical axis value was obtained after surgery. RESULTS: This comparative study between the predictive corrective, using 3D CAD weight-bearing simulated guidance technique, and post-operative mechanical axis value, analysed with t-test statistical analysis, showed the insignificant difference ( p > 0.05). CONCLUSION: We conclude that the 3D CAD weight-bearing simulated guidance technique has good accuracy as preoperative planning of open-wedge HTO for succession surgery.

Fixation of femoral attachment: anterior cruciate ligament avulsion fracture with arthroscopy suture loop technique.

Anterior cruciate ligament (ACL) avulsion fracture is rare and mostly occur in tibial attachment. Avulsion fracture of femoral attachment of ACL was uncommon and mostly reported in skeletally immature patient. This article aims to report an interesting case of femoral attachment-ACL avulsion fracture in skeletally mature patient with arthroscopic suture loop fixation.A 32-year-old man, with no significant medical-surgical history, sustained a right non-contact pivoting knee injury during soccer competition. Plain radiographs of knee joint demonstrated intra-articular bone fragment in the intercondylar notch space. The MRI confirmed femoral attachment-ACL avulsion fracture. Then, we planned to perform fixation of femoral attachment-ACL avulsion fracture with arthroscopy suture loop technique. At 5 months after surgery, patient had no pain and swelling knee. The physical examination demonstrated negative Lachman test, anterior drawer test, pivot shift test and patient can return to preinjury daily activity and sport activities.