1.
Bioorg Med Chem Lett
; 20(10): 3161-4, 2010 May 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20399651
RESUMEN
High-throughput screening identified compound 1 as a potent P2X(7) receptor antagonist suitable for lead optimisation. Structure-activity relationships (SAR) of a series of (1H-pyrazol-4-yl)acetamides were investigated and compound 32 was identified as a potent P2X(7) antagonist with enhanced potency and favourable physicochemical and pharmacokinetic properties.