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1.
J Vis ; 21(3): 8, 2021 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-33661280

RESUMEN

From measurements of wavefront aberrations in 16 emmetropic eyes, we calculated where objects in the world create best-focused images across the central 27\(^\circ\) (diameter) of the retina. This is the retinal conjugate surface. We calculated how the surface changes as the eye accommodates from near to far and found that it mostly maintains its shape. The conjugate surface is pitched top-back, meaning that the upper visual field is relatively hyperopic compared to the lower field. We extended the measurements of best image quality into the binocular domain by considering how the retinal conjugate surfaces for the two eyes overlap in binocular viewing. We call this binocular extension the blur horopter. We show that in combining the two images with possibly different sharpness, the visual system creates a larger depth of field of apparently sharp images than occurs with monocular viewing. We examined similarities between the blur horopter and its analog in binocular vision: the binocular horopter. We compared these horopters to the statistics of the natural visual environment. The binocular horopter and scene statistics are strikingly similar. The blur horopter and natural statistics are qualitatively, but not quantitatively, similar. Finally, we used the measurements to refine what is commonly referred to as the zone of clear single binocular vision.


Asunto(s)
Acomodación Ocular/fisiología , Visión Binocular/fisiología , Campos Visuales , Emetropía/fisiología , Humanos , Retina/fisiología
2.
J Vis ; 20(10): 7, 2020 10 01.
Artículo en Inglés | MEDLINE | ID: mdl-33007081

RESUMEN

We investigated the classical question of why visual acuity decreases with decreasing retinal illuminance by holding retinal eccentricity fixed while illumination varied. Our results indicate that acuity is largely independent of illuminance at any given retinal location, which suggests that under classical free-viewing conditions acuity improves as illumination increases from rod threshold to rod saturation because the retinal location of the stimulus is permitted to migrate from a peripheral location of maximum sensitivity but poor acuity to the foveal location of maximum acuity but poor sensitivity. Comparison with anatomical sampling density of retinal neurons suggests that mesopic acuity at all eccentricities and scotopic acuity for eccentricities beyond about 20° is limited by the spacing of midget ganglion cells. In central retina, however, scotopic acuity is further limited by spatial filtering due to spatial summation within the large, overlapping receptive fields of the A-II class of amacrine cells interposed in the rod pathway between rod bipolars and midget ganglion cells. Our results offer a mechanistic interpretation of the clinical metrics for low-luminance visual dysfunction used to monitor progression of retinal disease.


Asunto(s)
Retina/fisiología , Agudeza Visual/fisiología , Campos Visuales , Humanos , Iluminación , Estimulación Luminosa/métodos
3.
J Vis ; 20(7): 20, 2020 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-32692825

RESUMEN

Visual image quality metrics combine comprehensive descriptions of ocular optics (from wavefront error) with a measure of the neural processing of the visual system (neural contrast sensitivity). To improve the ability of these metrics to track real-world changes in visual performance and to investigate the roles and interactions of those optical and neural components in foveal visual image quality as functions of age and target luminance, models of neural contrast sensitivity were constructed from the literature as functions of (1) retinal illuminance (Trolands, td), and (2) retinal illuminance and age. These models were then incorporated into calculation of the visual Strehl ratio (VSX). Best-corrected VSX values were determined at physiological pupil sizes over target luminances of 104 to 10-3 cd/m2 for 146 eyes spanning six decades of age. Optical and neural components of the metrics interact and contribute to visual image quality in three ways. At target luminances resulting in >900 td at physiological pupil size, neural processing is constant, and only aberrations (that change as pupil size changes with luminance) affect the metric. At low mesopic luminances below where pupil size asymptotes to maximum, optics are constant (maximum pupil), and only the neural component changes with luminance. Between these two levels, both optical and neural components of the metrics are affected by changes in target luminance. The model that accounted for both retinal illuminance and age allowed VSX, termed VSX(td,a), to best track visual acuity trends (measured at 160 and 200 cd/m2) as a function of age (20s through 70s) from the literature. Best-corrected VSX(td,a) decreased by 2.24 log units between maximum and minimum target luminances in the youngest eyes and by 2.58 log units in the oldest. The decrease due to age was more gradual at high target luminances (0.70 log units) and more pronounced as target luminance decreased (1.04 log units).


Asunto(s)
Envejecimiento/fisiología , Luz , Retina/fisiología , Percepción Visual/fisiología , Adulto , Anciano , Anciano de 80 o más Años , Sensibilidad de Contraste/fisiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pupila/fisiología , Visión Ocular/fisiología , Agudeza Visual/fisiología , Adulto Joven
4.
Annu Rev Vis Sci ; 6: 469-489, 2020 09 15.
Artículo en Inglés | MEDLINE | ID: mdl-32543966

RESUMEN

In this review, I develop an empirically based model of optical image formation by the human eye, followed by neural sampling by retinal ganglion cells, to demonstrate the perceptual effects of blur, aliasing, and distortion of visual space in the brain. The optical model takes account of ocular aberrations and their variation across the visual field, in addition to variations of defocus due to variation of target vergence in three-dimensional scenes. Neural sampling by retinal ganglion cells with receptive field size and spacing that increases with eccentricity is used to visualize the neural image carried by the optic nerve to the brain. Anatomical parameters are derived from psychophysical studies of sampling-limited visual resolution of sinusoidal interference fringes. Retinotopic projection of the neural image onto brainstem nuclei reveals features of the neural image in a perceptually uniform brain space where location and size of visual objects may be measured by counting neurons.


Asunto(s)
Células Ganglionares de la Retina/fisiología , Visión Ocular/fisiología , Campos Visuales/fisiología , Humanos , Psicofísica , Agudeza Visual/fisiología
5.
J Vis ; 19(9): 13, 2019 08 01.
Artículo en Inglés | MEDLINE | ID: mdl-31434109

RESUMEN

We aimed to create individual eye models that accurately reproduce the empirical measurements of wave-front aberrations across the visual field at different accommodative states, thus providing a mechanistic explanation for the changes in the eye's aberration structure due to accommodation. Structural parameters of a generic eye model were optimized using optical design software to account for published measurements of wave-front aberrations measured for 19 individuals at 37 test locations over the central 30°-diameter visual field at eight levels of accommodative demand. Biometric data for individual eyes were used as starting values and normative data were used to constrain optimizations to anatomically reasonable values. Customizations of the accommodating eye model accurately accounted for ocular aberrations over the central 30° of visual field with an averaged root mean square fitting error typically below 0.2 µm at any given field location. Optimized structural parameters of the eye models were anatomically reasonable and changed in the expected way when accommodating. Accuracy for representing spherical aberration was significantly improved by relaxing anatomical constraints on the anterior surface of the lens to compensate for not including gradient-index media. Use of the model to compute pan-retinal image quality revealed large penalties of accommodative lag for activating photoreceptor responses to the retinal image.


Asunto(s)
Acomodación Ocular/fisiología , Aberración de Frente de Onda Corneal/fisiopatología , Trastornos de la Visión/fisiopatología , Humanos , Modelos Biológicos , Refracción Ocular/fisiología , Campos Visuales/fisiología
6.
Ophthalmic Physiol Opt ; 39(4): 232-244, 2019 07.
Artículo en Inglés | MEDLINE | ID: mdl-31172533

RESUMEN

PURPOSE: This report uses the principles of geometrical optics to compute the optical point-spread function (PSF) from the wavefront error function. METHOD: Step 1 uses Prentice's rule to determine the spatial form of the PSF established by tracing a field of rays from the eye's exit pupil to the retina. Ray vergence is related to the slope of the wavefront error function, which enables the mapping of light rays to produce a retinal 'spot diagram'. Step 2 completes the PSF by assigning an irradiance value to each ray in the spot diagram. RESULTS AND CONCLUSIONS: Spot irradiance is inversely proportional to the Gaussian curvature (i.e. the product of principal curvatures) of each local region of wavefront error surface centered on the corresponding ray. The Gaussian curvature, in turn, may be computed as the determinant of the vergence error matrix associated with each point on the wavefront error surface. Elements of the vergence error matrix consist of sums and differences of the local power vector components M, J0 and J45 . This method is shown to be equivalent to published derivations of the geometric PSF using the Jacobian of the ray mapping function and equivalent also to the Hessian of the wavefront error function. Examples are presented for the familiar cases of spherical and astigmatic blur as well as for higher order aberrations and the formation of caustics in the retinal image.


Asunto(s)
Astigmatismo/fisiopatología , Aberración de Frente de Onda Corneal/fisiopatología , Óptica y Fotónica/métodos , Trastornos de la Visión/fisiopatología , Humanos , Matemática , Refracción Ocular/fisiología
7.
J Opt Soc Am A Opt Image Sci Vis ; 36(4): B35-B43, 2019 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-31044953

RESUMEN

Visual detection of small black objects surrounded by a light background depends on background luminance, pupil size, optical blur, and object size. Holding pupil and optics fixed, we measured the minimum background luminance needed for foveal detection of small black targets as a function of target size. For all three observers, absolute threshold varied inversely with target area when disk diameter subtended less than 10' of visual angle. For target diameter ≥10', threshold remained constant at about 0.3 Td, which was also the absolute threshold for detecting light spots 10' or larger in diameter on a black background. These results are consistent with Ricco's law of spatial summation: a "black hole" is just detectable when the background luminance is sufficiently high for its absence inside the Ricco area to reduce 555 nm photon flux by 7500 photons/s, which is the same change needed to detect light spots on a black surround. These results can be accounted for by a differential pair of Ricco detectors, each about the size of the receptive field center of magocellular retinal ganglion cells when projected into object space through the eye's weakly aberrated optical system. Statistical analysis of the model suggests the quantum fluctuations due to internal, biological noise (i.e., "scotons") are a greater handicap than the photon fluctuations inherent in the light stimulus at absolute foveal threshold.


Asunto(s)
Oscuridad , Fóvea Central/fisiología , Umbral Sensorial/efectos de la radiación , Fóvea Central/efectos de la radiación , Modelos Biológicos , Estimulación Luminosa
8.
J Opt Soc Am A Opt Image Sci Vis ; 36(4): B97-B102, 2019 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-31044967

RESUMEN

Starbursts seen around small bright lights at night have been attributed to optical scatter, diffraction, or aberrations. We manipulated pupil aperture and aberrations to investigate the entopic appearance of perceived starbursts. The impact of circular, annular, and wedge-shaped pupil apertures, and spherical aberration sign and magnitude were used to identify pupil sub-apertures responsible for each radial perceived starburst line. Local intensity distributions within the starbursts mapped onto unique sub-regions of the pupil of both phakic and pseudophakic eyes, consistent with the hypothesis that ocular aberrations are the cause of starbursts. In paraxially focused eyes, the size of starbursts is predicted by the amount of spherical aberration, and starburst orientation is either the same or 180 deg rotated from the pupil region that creates each starburst line. No starbursts are seen when the pupil diameter is smaller than 3 mm. Replacing the eye's natural lens with a radially symmetric and optically homogeneous intraocular lens reduced the observed number of starbursts by 50%. Geometrical optics modeling including the measured aberrations of an individual eye can reveal point spread function structure that captures some of the key elements of the entopic perceptions.


Asunto(s)
Fenómenos Ópticos , Pupila/fisiología , Humanos , Psicofísica
9.
Optom Vis Sci ; 96(4): 291-300, 2019 04.
Artículo en Inglés | MEDLINE | ID: mdl-30907860

RESUMEN

SIGNIFICANCE: Approximately 10% of the lowercase text on nonprescription drug labels is smaller than the 1 mm required by the Food and Drug Administration. The small size, combined with the progressive decline in accommodative amplitude and gain, poses a reading challenge for middle-aged emerging presbyopes. PURPOSE: The purpose of this study was to evaluate the impact of progressing presbyopia and near adds on the ability of middle-aged patients to read small text routinely encountered on product labels. METHODS: Geometrical optics was used to determine the impact of changing viewing distance, accommodation, and pupil size on retinal blur size. We photographed 261 consumer product labels in grocery, personal care, and nonprescription (over-the-counter) drug categories and used character recognition software to identify and size 255,298 printed letters. We computed the impact of viewing distance on the ratio of blur to letter detail and used published blur ratios of ≤4 and ≤2 to identify the conditions that allowed for letter recognition and proficient reading, respectively. RESULTS: Median/mode lowercase letter heights (in millimeters) were 1.39/1.16, 1.29/1.15, and 1.18/1.01, respectively, for groceries, personal care, and over-the-counter drug categories. Despite the increased angular subtense of approaching letters, blur ratios generally increased with reduced viewing distance because of increased defocus. Increased viewing distance decreased blur, but small (e.g., 1 mm) letters became too small to read proficiently (angular size <10 arcminutes) for distances beyond 37 cm. With larger pupils, blur ratios were too large to support proficient reading when accommodative amplitude dropped to ≤3 diopters. An add power sufficient to bring the far point closer than 37 cm was required to proficiently read small text. CONCLUSIONS: Product labels, especially nonprescription drug packages, typically use fonts that are too small to be read proficiently by unaided emmetropes with emerging presbyopia. This problem can be ameliorated by correction of presbyopia at an earlier age and with higher add powers.


Asunto(s)
Acomodación Ocular/fisiología , Etiquetado de Medicamentos , Medios de Comunicación de Masas , Presbiopía/fisiopatología , Lectura , Trastornos de la Visión/fisiopatología , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pupila/fisiología , Agudeza Visual/fisiología
10.
J. optom. (Internet) ; 11(3): 144-152, jul.-sept. 2018. graf
Artículo en Inglés | IBECS | ID: ibc-178489

RESUMEN

Purpose: The aim of this work was to examine the impact of Seidel spherical aberration (SA) on optimum refractive state for detecting and discriminating small bright lights on a dark background. Methods: An adaptive-optics system was used to correct ocular aberrations of cyclopleged eyes and then systematically introduce five levels of Seidel SA for a 7-mm diameter pupil: 0, ± 0.18, and ± 0.36 diopters (D )mm-2. For each level of SA, subjects were required to detect one or resolve two points of light (0.54 arc min diameter) on a dark background. Refractive error was measured by adjusting stimulus vergence to minimize detection and resolution thresholds. Two other novel focusing tasks for single points of light required maximizing the perceived intensity of a bright point's core and minimizing its overall perceived size (i.e. minimize starburst artifacts). Except for the detection task, luminance of the point of light was 1000 cd m-2 on a black background lower than 0.5 cdm-2. Results: Positive SA introduced myopic shifts relative to the best subjective focus for dark letters on a bright background when there was no SA, whereas negative SA introduced hyperopic shifts in optimal focus. The changes in optimal focus were -1.7, -2.4, -2.0, and -9.2 D of focus per D mm-2 of SA for the detection task, resolution task, and maximization of core's intensity and minimization of size, respectively. Conclusion: Ocular SA can be a significant contributor to changes in refractive state when viewing high-contrast point sources typically encountered in nighttime environments


Objetivo: El objetivo de este estudio fue examinar el impacto de la aberración esférica de Seidel (AS) sobre el estado refractivo óptimo para detectar y discriminar las luces brillantes de pequeño tamaño sobre un fondo oscuro. Métodos: Se utilizó un sistema de óptica adaptativa para corregir las aberraciones oculares de ojos bajo cicloplegía, e introducir sistemáticamente cinco valores de AS para una pupila de 7 mm de diámetro: 0, ± 0,18, y ± 0,36 dioptrías (D) mm-2. Para cada valor de AS se solicitó a los sujetos que detectaran un punto de luz, o resolvieran dos puntos (cada punto subtendía 0,54 minutos de arco de diámetro) sobre un fondo oscuro. El error refractivo se midió ajustando la vergencia del estímulo, para minimizar los umbrales de detección y resolución. Los sujetos realizaron además otras dos tareas observando un sólo punto luminoso y en las que tenían que maximizar la intensidad percibida del núcleo del punto luminoso o minimizar el tamaño de la imagen percibida (es decir, minimizar el "starburst"). Excepto para la tarea de detección, la luminancia del punto de luz fue de 1000 cd m-2 sobre un fondo negro con un valor inferior a 0,5 cd m-2. Resultados: La AS positiva introdujo cambios miópicos respecto al mejor enfoque subjetivo para letras oscuras sobre un fondo luminoso sin AS, mientras que la AS negativa introdujo cambios hipermetrópicos respecto al enfoque óptimo. Estos cambios fueron -1,7,-2,4,-2,0, y -9,2 D de enfoque por D mm-2 de AS para la tarea de detección, la tarea de resolución, la maximización de la intensidad del núcleo y la minimización de su tamaño, respectivamente. Conclusión: La AS ocular puede ser un factor que influye significativamente en los cambios en el estado refractivo, al visualizar las fuentes puntuales de alto contraste típicas de los entornos nocturnos


Asunto(s)
Humanos , Adulto , Persona de Mediana Edad , Aberración de Frente de Onda Corneal/fisiopatología , Visión Nocturna/fisiología , Refracción Ocular/fisiología , Agudeza Visual/fisiología , Errores de Refracción/fisiopatología , Óptica y Fotónica , Estimulación Luminosa/métodos
11.
Ophthalmic Physiol Opt ; 38(4): 432-446, 2018 07.
Artículo en Inglés | MEDLINE | ID: mdl-29736941

RESUMEN

PURPOSE: Eccentric photorefraction and Purkinje image tracking are used to estimate refractive state and eye position simultaneously. Beyond vision screening, they provide insight into typical and atypical visual development. Systematic analysis of the effect of refractive error and spectacles on photorefraction data is needed to gauge the accuracy and precision of the technique. METHODS: Simulation of two-dimensional, double-pass eccentric photorefraction was performed (Zemax). The inward pass included appropriate light sources, lenses and a single surface pupil plane eye model to create an extended retinal image that served as the source for the outward pass. Refractive state, as computed from the luminance gradient in the image of the pupil captured by the model's camera, was evaluated for a range of refractive errors (-15D to +15D), pupil sizes (3 mm to 7 mm) and two sets of higher-order monochromatic aberrations. Instrument calibration was simulated using -8D to +8D trial lenses at the spectacle plane for: (1) vertex distances from 3 mm to 23 mm, (2) uncorrected and corrected hyperopic refractive errors of +4D and +7D, and (3) uncorrected and corrected astigmatism of 4D at four different axes. Empirical calibration of a commercial photorefractor was also compared with a wavefront aberrometer for human eyes. RESULTS: The pupil luminance gradient varied linearly with refractive state for defocus less than approximately 4D (5 mm pupil). For larger errors, the gradient magnitude saturated and then reduced, leading to under-estimation of refractive state. Additional inaccuracy (up to 1D for 8D of defocus) resulted from spectacle magnification in the pupil image, which would reduce precision in situations where vertex distance is variable. The empirical calibration revealed a constant offset between the two clinical instruments. CONCLUSIONS: Computational modelling demonstrates the principles and limitations of photorefraction to help users avoid potential measurement errors. Factors that could cause clinically significant errors in photorefraction estimates include high refractive error, vertex distance and magnification effects of a spectacle lens, increased higher-order monochromatic aberrations, and changes in primary spherical aberration with accommodation. The impact of these errors increases with increasing defocus.


Asunto(s)
Acomodación Ocular/fisiología , Simulación por Computador , Modelos Biológicos , Optometría/métodos , Pupila/fisiología , Refracción Ocular/fisiología , Errores de Refracción/diagnóstico , Adolescente , Adulto , Calibración , Niño , Preescolar , Anteojos , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Errores de Refracción/fisiopatología , Adulto Joven
12.
J Opt Soc Am A Opt Image Sci Vis ; 35(5): 732-739, 2018 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-29726489

RESUMEN

The visual image quality metric the visual Strehl ratio (VSX) combines a comprehensive description of the optics of an eye (wavefront error) with an estimate of the photopic neural processing of the visual system, and has been shown to be predictive of subjective best focus and well correlated with change in visual performance. Best-corrected visual image quality was determined for 146 eyes, and the quantitative relation of VSX, age, and pupil size is presented, including 95% confidence interval norms for age groups between 20 and 80 years and pupil diameters from 3 to 7 mm. These norms were validated using an independently collected population of wavefront error measurements. The best visual image quality was found in young eyes at smaller pupil sizes. Increasing pupil size caused a more rapid decrease in VSX than increasing age. These objectively determined benchmarks represent the best theoretical levels of visual image quality achievable with a sphere, cylinder, and axis correction in normal eyes and can be used to evaluate both traditional and wavefront-guided optical corrections provided by refractive surgery, contact lenses, and spectacles.


Asunto(s)
Envejecimiento/fisiología , Pupila/fisiología , Percepción Visual/fisiología , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia , Refracción Ocular/fisiología , Adulto Joven
13.
J Opt Soc Am A Opt Image Sci Vis ; 35(5): 813-816, 2018 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-29726494

RESUMEN

Trolands are a widely used measure of retinal illuminance in vision science and visual optics, but disagreements exist for the definition and interpretation of this photometric unit. The purpose of this communication is to resolve the confusion by providing a sound conceptual basis for interpreting trolands as a measure of angular flux density incident upon the retina. Using a simplified optical analysis, we show that the troland value of an extended source is the intensity in micro-candelas of an equivalent point source located at the eye's posterior nodal point that produces the same illuminance in the retinal image as does the extended source. This optical interpretation of trolands reveals that total light flux in the image of an extended object is the product of the troland value of the source and the solid angle subtended by the source at the first nodal point, independent of eye size.


Asunto(s)
Fenómenos Fisiológicos Oculares , Estimulación Luminosa , Pupila/fisiología , Retina/fisiología , Humanos , Retina/efectos de la radiación
14.
J Optom ; 11(3): 144-152, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29292240

RESUMEN

PURPOSE: The aim of this work was to examine the impact of Seidel spherical aberration (SA) on optimum refractive state for detecting and discriminating small bright lights on a dark background. METHODS: An adaptive-optics system was used to correct ocular aberrations of cyclopleged eyes and then systematically introduce five levels of Seidel SA for a 7-mm diameter pupil: 0,±0.18, and±0.36diopters (D)mm-2. For each level of SA, subjects were required to detect one or resolve two points of light (0.54 arc min diameter) on a dark background. Refractive error was measured by adjusting stimulus vergence to minimize detection and resolution thresholds. Two other novel focusing tasks for single points of light required maximizing the perceived intensity of a bright point's core and minimizing its overall perceived size (i.e. minimize starburst artifacts). Except for the detection task, luminance of the point of light was 1000cdm-2 on a black background lower than 0.5cdm-2. RESULTS: Positive SA introduced myopic shifts relative to the best subjective focus for dark letters on a bright background when there was no SA, whereas negative SA introduced hyperopic shifts in optimal focus. The changes in optimal focus were -1.7, -2.4, -2.0, and -9.2D of focus per Dmm-2 of SA for the detection task, resolution task, and maximization of core's intensity and minimization of size, respectively. CONCLUSION: Ocular SA can be a significant contributor to changes in refractive state when viewing high-contrast point sources typically encountered in nighttime environments.


Asunto(s)
Aberración de Frente de Onda Corneal/fisiopatología , Visión Nocturna/fisiología , Refracción Ocular/fisiología , Errores de Refracción/fisiopatología , Agudeza Visual/fisiología , Adulto , Humanos , Persona de Mediana Edad , Óptica y Fotónica , Estimulación Luminosa/métodos
15.
J Vis ; 17(3): 24, 2017 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-28362902

RESUMEN

In this study we investigated the impact of accommodation on axial and oblique astigmatism along 12 meridians of the central 30° of visual field and explored the compensation of corneal first-surface astigmatism by the remainder of the eye's optical system. Our experimental evidence revealed no systematic effect of accommodation on either axial or oblique astigmatism for two adult populations (myopic and emmetropic eyes). Although a few subjects exhibited systematic changes in axial astigmatism during accommodation, the dioptric value of these changes was much smaller than the amount of accommodation. For most subjects, axial and oblique astigmatism of the whole eye are both less than for the cornea alone, which indicates a compensatory role for internal optics at all accommodative states in both central and peripheral vision. A new method for determining the eye's optical axis based on visual field maps of oblique astigmatism revealed that, on average, the optical axis is 4.8° temporal and 0.39° superior to the foveal line-of-sight in object space, which agrees with previous results obtained by different methodologies and implies that foveal astigmatism includes a small amount of oblique astigmatism (0.06 D on average). Customized optical models of each eye revealed that oblique astigmatism of the corneal first surface is negligible along the pupillary axis for emmetropic and myopic eyes. Individual variation in the eye's optical axis is due in part to misalignment of the corneal and internal components that is consistent with tilting of the crystalline lens relative to the pupillary axis.


Asunto(s)
Acomodación Ocular/fisiología , Astigmatismo/fisiopatología , Campos Visuales/fisiología , Aberrometría , Adulto , Topografía de la Córnea , Emetropía/fisiología , Femenino , Humanos , Masculino , Miopía/fisiopatología , Refracción Ocular , Adulto Joven
16.
J Opt Soc Am A Opt Image Sci Vis ; 34(4): 481-492, 2017 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-28375317

RESUMEN

Our purpose is to develop a computational approach that jointly assesses the impact of stimulus luminance and pupil size on visual quality. We compared traditional optical measures of image quality and those that incorporate the impact of retinal illuminance dependent neural contrast sensitivity. Visually weighted image quality was calculated for a presbyopic model eye with representative levels of chromatic and monochromatic aberrations as pupil diameter was varied from 7 to 1 mm, stimulus luminance varied from 2000 to 0.1 cd/m2, and defocus varied from 0 to -2 diopters. The model included the effects of quantal fluctuations on neural contrast sensitivity. We tested the model's predictions for five cycles per degree gratings by measuring contrast sensitivity at 5 cyc/deg. Unlike the traditional Strehl ratio and the visually weighted area under the modulation transfer function, the visual Strehl ratio derived from the optical transfer function was able to capture the combined impact of optics and quantal noise on visual quality. In a well-focused eye, provided retinal illuminance is held constant as pupil size varies, visual image quality scales approximately as the square root of illuminance because of quantum fluctuations, but optimum pupil size is essentially independent of retinal illuminance and quantum fluctuations. Conversely, when stimulus luminance is held constant (and therefore illuminance varies with pupil size), optimum pupil size increases as luminance decreases, thereby compensating partially for increased quantum fluctuations. However, in the presence of -1 and -2 diopters of defocus and at high photopic levels where Weber's law operates, optical aberrations and diffraction dominate image quality and pupil optimization. Similar behavior was observed in human observers viewing sinusoidal gratings. Optimum pupil size increases as stimulus luminance drops for the well-focused eye, and the benefits of small pupils for improving defocused image quality remain throughout the photopic and mesopic ranges. However, restricting pupils to <2 mm will cause significant reductions in the best focus vision at low photopic and mesopic luminances.


Asunto(s)
Aberración de Frente de Onda Corneal/fisiopatología , Luz , Pupila/fisiología , Visión Ocular/fisiología , Animales , Simulación por Computador , Sensibilidad de Contraste/fisiología , Humanos , Óptica y Fotónica , Presbiopía/fisiopatología , Reflejo Pupilar/efectos de la radiación
17.
Ophthalmic Physiol Opt ; 37(3): 305-316, 2017 05.
Artículo en Inglés | MEDLINE | ID: mdl-28281302

RESUMEN

PURPOSE: Oblique astigmatism is a prominent optical aberration of peripheral vision caused by oblique incidence of rays striking the refracting surfaces of the cornea and crystalline lens. We inquired whether oblique astigmatism from these two sources should be expected, theoretically, to have the same or opposite signs across the visual field at various states of accommodation. METHODS: Oblique astigmatism was computed across the central visual field for a rotationally-symmetric schematic-eye using optical design software. Accommodative state was varied by altering the apical radius of curvature and separation of the biconvex lens's two aspheric surfaces in a manner consistent with published biometry. Oblique astigmatism was evaluated separately for the whole eye, the cornea, and the isolated lens over a wide range of surface curvatures and asphericity values associated with the accommodating lens. We also computed internal oblique astigmatism by subtracting corneal oblique astigmatism from whole-eye oblique astigmatism. RESULTS: A visual field map of oblique astigmatism for the cornea in the Navarro model follows the classic, textbook description of radially-oriented axes everywhere in the field. Despite large changes in surface properties during accommodation, intrinsic astigmatism of the isolated human lens for collimated light is also radially oriented and nearly independent of accommodation both in theory and in real eyes. However, the magnitude of ocular oblique astigmatism is smaller than that of the cornea alone, indicating partial compensation by the internal optics. This implies internal oblique astigmatism (which includes wavefront propagation from the posterior surface of the cornea to the anterior surface of the lens and intrinsic lens astigmatism) must have tangentially-oriented axes. This non-classical pattern of tangential axes for internal astigmatism was traced to the influence of corneal power on the angles of incidence of rays striking the internal lens. CONCLUSIONS: Partial compensation of corneal astigmatism by internal optics is due mainly to the highly converging nature of wavefronts incident upon the lens resulting from corneal refraction. The degree of compensation is quadratically dependent on eccentricity but is expected to diminish as the eye accommodates. Neutralising the cornea by index-matching defeats internal compensation, revealing classical, radially-oriented oblique astigmatism in the isolated lens.


Asunto(s)
Astigmatismo/terapia , Córnea/patología , Lentes Intraoculares , Modelos Teóricos , Refracción Ocular/fisiología , Campos Visuales , Astigmatismo/diagnóstico , Astigmatismo/fisiopatología , Topografía de la Córnea/métodos , Humanos , Óptica y Fotónica/métodos
18.
J Cataract Refract Surg ; 42(9): 1288-1296, 2016 09.
Artículo en Inglés | MEDLINE | ID: mdl-27697246

RESUMEN

PURPOSE: To test the hypothesis that binocular depth of field can be expanded while retaining high-quality vision at intermediate distances by combining anisometropia (monovision) and simultaneous vision bifocals. SETTING: School of Optometry, Indiana University, Bloomington, Indiana, USA. DESIGN: Prospective research study. METHODS: A computational polychromatic model was used to simulate retinal images as seen through a pseudophakic eye with a diffractive bifocal for a range of target distances. Computationally blurred stimuli were presented dichoptically, simulating a binocular pseudophakic person with 1 emmetropic eye and 1 eye with myopia of 0.40 diopter (D), 0.80 D, or 1.20 D. Binocular visual acuity was measured for computationally blurred high-contrast Sloan letters. RESULTS: Ten subjects participated in this study. The emmetropic eye achieved best vision at infinity and near distance specified by the addition (add) power, while the myopic eye peak acuities were achieved at shorter viewing distances. Having 1 myopic bifocal eye had no effect on distance acuities. With a bifocal add of 2.20 D and 1.20 D of anisometropia, the binocular depth of focus was more than 3.00 D and provided binocular acuities of better than 20/20 throughout this range. For each target distance, the binocular acuities closely approached those of the better-focused eye. CONCLUSIONS: By careful selection of unilateral myopia and bilateral use of high-quality bifocal lenses, high intermediate distance acuities can exist with a large depth of field. This approach can improve intermediate vision and expand depth of field without compromising best achievable distance and near acuities. FINANCIAL DISCLOSURE: None of the authors has a financial or proprietary interest in any material or method mentioned.


Asunto(s)
Implantación de Lentes Intraoculares , Visión Binocular , Agudeza Visual , Extracción de Catarata , Humanos , Lentes Intraoculares , Estudios Prospectivos , Seudofaquia
19.
J Opt Soc Am A Opt Image Sci Vis ; 33(9): 1723-34, 2016 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-27607493

RESUMEN

The interaction between oblique and axial astigmatism was investigated analytically (generalized Coddington's equations) and numerically (ray tracing) for a theoretical eye model with a single refracting surface. A linear vector-summation rule for power vector descriptions of axial and oblique astigmatism was found to account for their interaction over the central 90° diameter of the visual field. This linear summation rule was further validated experimentally using a physical eye model measured with a laboratory scanning aberrometer. We then used the linear summation rule to evaluate the relative contributions of axial and oblique astigmatism to the total astigmatism measured across the central visual field. In the central visual field, axial astigmatism dominates because the oblique astigmatism is negligible near the optical axis. At intermediate eccentricities, axial and oblique astigmatism may have equal magnitude but orthogonal axes, which nullifies total astigmatism at two locations in the visual field. At more peripheral locations, oblique astigmatism dominates axial astigmatism, and the axes of total astigmatism become radially oriented, which is a trait of oblique astigmatism. When eccentricity is specified relative to a foveal line-of-sight that is displaced from the eye's optical axis, asymmetries in the visual field map of total astigmatism can be used to locate the optical axis empirically and to estimate the relative contributions of axial and oblique astigmatism at any retinal location, including the fovea. We anticipate the linear summation rule will benefit many topics in vision science (e.g., peripheral correction, emmetropization, meridional amblyopia) by providing improved understanding of how axial and oblique astigmatism interact to produce net astigmatism.


Asunto(s)
Astigmatismo/fisiopatología , Ojo/fisiopatología , Modelos Biológicos , Campos Visuales
20.
Invest Ophthalmol Vis Sci ; 57(7): 3010-6, 2016 06 01.
Artículo en Inglés | MEDLINE | ID: mdl-27273719

RESUMEN

PURPOSE: Amplitude of accommodation (AA) is reportedly greater for myopic eyes than for hyperopic eyes. We investigated potential explanations for this difference. METHODS: Analytical analysis and computer ray tracing were performed on two schematic eye models of axial ametropia. Using paraxial and nonparaxial approaches, AA was specified for the naked and the corrected eye using the anterior corneal surface as the reference plane. RESULTS: Assuming that axial myopia is due entirely to an increase in vitreous chamber depth, AA increases with the amount of myopia for two reasons that have not always been taken into account. First is the choice of reference location for specifying refractive error and AA in diopters. When specified relative to the cornea, AA increases with the degree of myopia more than when specified relative to the eye's first Gaussian principal plane. The second factor is movement of the eye's second Gaussian principal plane toward the retina during accommodation, which has a larger dioptric effect in shorter eyes. CONCLUSIONS: Using the corneal plane (placed at the corneal vertex) as the reference plane for specifying accommodation, AA depends slightly on the axial length of the eye's vitreous chamber. This dependency can be reduced significantly by using a reference plane located 4 mm posterior to the corneal plane. A simple formula is provided to help clinicians and researchers obtain a value of AA that closely reflects power changes of the crystalline lens, independent of axial ametropia and its correction with lenses.


Asunto(s)
Acomodación Ocular/fisiología , Errores de Refracción/fisiopatología , Adulto , Longitud Axial del Ojo/fisiología , Humanos , Hiperopía/fisiopatología , Modelos Biológicos , Miopía/fisiopatología , Refracción Ocular/fisiología
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