RESUMEN
We report a benzonatate overdose in a teenager resulting in life-threatening toxicity to increase awareness of this overdose, and discuss recent pediatric warnings and labeling information provided by the US Food and Drug Administration (FDA). After an overdose of benzonatate, a 13-yr-old female presented to our emergency department with coma, seizures, hypotension, prolonged QT interval on electrocardiogram, and metabolic acidosis. Benzonatate is an antitussive medication with sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite. Overdose is reported to cause coma, seizures, hypotension, tachycardia, ventricular dysrhythmias, and cardiac arrest. The FDA recently issued a Drug Safety Communication warning that accidental benzonatate ingestion in children younger than 10 years of age have increased risk of death and added the new information to the Warnings and Precautions section of benzonatate's label.
RESUMEN
Langmuir film properties, UV-vis spectroscopy, epifluorescence microscopy, and transmission electron microscopy were used to study CdSe quantum dots (QDs) in 2D. By combining these results, it was possible to determine the molar absorptivity, limiting nanoparticle area, luminescence property, and arrangement of the QDs in the monolayer films at the air-water interface. Either trioctylphosphine oxide (TOPO) or 1-octadecanethiol (ODT) stabilized the QDs. The data collected reveal that TOPO forms close-packed monolayers on the surface of the QDs and that ODT-stabilized QDs undergo alkyl chains interdigitation. It was also found that varying the nanoparticle size, nature of surfactant, surface pressure, and mixed monolayers could help engineer the 2D self-assembly of the QDs at the air-water interface. Of practical importance is the transfer of these monolayer films onto hydrophilic or hydrophobic solid substrates, which could be successfully accomplished via the Langmuir-Blodgett film deposition technique.
