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Bioorg Med Chem Lett
; 20(2): 657-61, 2010 Jan 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19962304
RESUMEN
Incorporation of pyridines and diazines into the biphenyl region of quinolone carboxylic acid derived M(1) positive allosteric modulators was investigated as a means of lowering plasma protein binding to enhance CNS exposure.