RESUMEN
Firefighters are exposed to several potentially carcinogenic fireground contaminants. The current NFPA 1851 washing procedures are less effective in cleaning due to the limited intensity of the washing conditions that are used. The 2020 edition of NFPA 1851 has added limited specialized cleaning for higher efficacy. The liquid carbon dioxide (CO2) laundering technique has gained popularity in recent years due to its availability to remove contaminants and its eco-friendliness. The primary aim of this study is to address the firefighter questions regarding the efficacy of cleaning with liquid CO2 and to compare it with the conventional washing technique. The unused turnout jackets were contaminated with a mixture of fireground contaminants. These turnout jackets were cleaned with conventional NFPA 1851-appoved aqueous washing and a commercially available liquid CO2 method. Post-cleaning samples were analyzed for contamination using pressurized solvent extraction and GC-MS. The liquid CO2 technique demonstrated considerable improvement in washing efficiency compared to the conventional washing.
RESUMEN
The National Fire Protection Association (NFPA) 1851 document provides guidelines for firefighters on the care and maintenance of their PPE, including decontamination practices. Firefighters are exposed to various toxic chemicals during fire suppression activities, making effective decontamination crucial for their safety. This study evaluated the efficacy of different washing parameters, including temperature, time, and surfactants, on cleaning outer-shell material contaminated with nine targeted compounds from three different functional groups: phenols, polycyclic aromatic hydrocarbons (PAHs), and phthalates. The study was conducted on both bench-scale and full-scale levels, with contaminated swatches washed in a water shaker bath in the bench-scale evaluation and full-sized washer extractors used in the full-scale evaluation. The results showed that bench-scale washing demonstrated similar trends in contaminant removal to full-scale washing. Importantly, the study highlighted the complexity of removing fireground contaminants from the personal protective ensemble (PPE). The findings of this study have practical implications for the firefighting industry as they provide insight into the effectiveness of different washing parameters for PPE decontamination. Future studies could explore the impact of repeated washing on PPE and investigate the potential for developing more efficient decontamination strategies. Ultimately, the study underscores the importance of ongoing efforts to ensure the safety of firefighters, who face significant occupational hazards.
RESUMEN
We argue that an unqualified use of the term solidarity in public health is not only equivocal but problematic toward the ends of public health. The term may be deployed normatively by public health advocates to strengthen the bonds among public health practitioners and refer to an ideal society in which the importance of interdependence among members ought to be acknowledged throughout the polity. We propose an important distinction between partisan solidarity and societal solidarity. Because any moralized belief in a vision of a broad societal solidarity will be a contested political ideal, political reality would limit solidarity based on such a vision to partisan solidarity. An idealized vision of societal solidarity is simply not politically feasible in pluralistic, liberal, democratic societies. However, although societal solidarity is unlikely with respect to any particular policy, it might be hoped for with respect to constitutional procedures that provide boundaries for the agon of the political process. We suggest that moralizing assertions of a solidaristic ideal in a pluralistic society might be counterproductive to generating the political support necessary for public health per se and establishing legitimate public health policy. A pragmatic political approach would be for public health advocates to generate sufficient strong political support for those public health policies that are most amenable to the political and social realities of a time and place.
Asunto(s)
Salud Pública , Política Pública , Humanos , PolíticaRESUMEN
Egg binding and excessive laying frequently affect avian patients, and in many cases the treatment includes suppression of egg production. Currently, for the suppression of egg production in avian patients, a gonadotropin-releasing hormone agonist, in the form of a deslorelin implant, is often used. However, the commercially available deslorelin implants have an undesired delayed onset, as well as a potential brief increase in gonadotropin secretion after administration ("flare-up" effect) that can lead to oviposition before the actual suppression of gonadotropins. The objective of this study was to investigate whether the prolactin inhibitor cabergoline suppresses ovulation and whether it could be used to bridge the time until the onset of effect by the deslorelin implant. We measured the effect of cabergoline (30 µg/kg PO q24h × 14 days), deslorelin implants (4.7 mg SC), and a combination of both on egg laying and plasma prolactin concentrations in 37 quail (Coturnix japonica) over 6 weeks. Quail were divided into 4 groups: group DesCab (deslorelin implant and cabergoline oral; n = 9); group DesPlac (deslorelin implant and placebo oral; n = 9); group PlacCab (placebo implant and cabergoline oral; n = 9); and group PlacPlac (placebo implant and placebo oral; n = 10). Regular egg laying stopped in 100% (9/9) of birds in group DesCab and 78% (7/ 9) of birds in group DesPlac within 5 days of placing the deslorelin implant. No bird ceased egg production in group PlacCab (0/9), and 10% of birds ceased egg production intermittently in group PlacPlac (1/10). Treatment with the deslorelin implant (P < .001) and with cabergoline (P = .04) had a significant (negative) influence on plasma prolactin concentrations compared with the baseline. The interaction of deslorelin and cabergoline treatment, as well as time after initiation of treatment, did not have a significant effect on plasma prolactin concentrations. These results show that daily oral cabergoline has no significant influence on egg laying and only a minor biologically nonsignificant effect on lowering the relative plasma prolactin concentrations in quail.
Asunto(s)
Coturnix , Codorniz , Animales , Cabergolina/farmacología , Femenino , Oviposición , Prolactina/farmacología , Pamoato de Triptorelina/análogos & derivadosRESUMEN
Introducing males to seasonally anestrous females has been shown to increase LH concentrations and hasten the first ovulation in ewes and goat does. Investigation of this sociosexual phenomenon in mares has not been well studied. The objective of this study was to determine if direct or indirect exposure of anestrous mares to a stallion would result in a similar increase in LH and hasten the first ovulation. In late February, mares were stratified by parity and age and assigned randomly to three treatments (n = 7/treatment): (1) DXP (direct exposure; mares housed adjacent to stallion and allowed direct contact for 2 h for 3 d/wk by placing the stallion into a cage in the center of a tease pen); (2) IXP (indirect exposure; mares housed in an adjacent pen to the stallion but not allowed direct contact); and (3) CON (control; mares housed away from stallion and not allowed direct or indirect exposure). During the first, third, and fifth treatment days, blood was collected hourly for 8 h beginning just before treatment initiation for measurement of LH and prolactin (PRL) concentrations. Hormone concentrations were analyzed as repeated measures and time from the first day of treatment to ovulation was analyzed using one-way ANOVA. Interval from treatment initiation to first ovulation did not differ (P > 0.05) among treatments: 36.3 ± 6.7, 42.8 ± 4.2, and 48.3 ± 4.2 d for DXP, IXP, and CON, respectively. When comparing the mares based on social status within treatment and level of direct interaction with the stallion, socially dominant DXP mares ovulated sooner (P < 0.05) than socially subordinate DXP mares (23.8 ± 3.2 and 53.0 ± 6.8 d, respectively). Although LH concentrations did not differ (P > 0.05) among treatments, a significant (P < 0.05) day effect was detected with concentrations being greater on the fifth treatment day compared with the first and third days. Concentrations of PRL were greater (P < 0.05) in IXP compared with DXP and CON, regardless of treatment day. Regardless of treatment, PRL concentrations were greater (P < 0.05) on the third treatment day, compared with the first and fifth days. We conclude that exposure of anestrous mares to a stallion, whether direct or indirect, to anestrous mares failed to elicit the same effects that have been observed in short-day breeders. The effect of stallion exposure on the onset of cyclicity in anestrous mares may be dependent on the duration of direct contact.
Asunto(s)
Anestro , Hormona Luteinizante , Animales , Femenino , Caballos , Masculino , Ovulación , Inducción de la Ovulación/veterinaria , Periodicidad , Embarazo , OvinosRESUMEN
Complex tumor microenvironmental (TME) features influence the outcome of cancer immunotherapy (IO). Here we perform immunogenomic analyses on 67 intratumor sub-regions of a PD-1 inhibitor-resistant melanoma tumor and 2 additional metastases arising over 8 years, to characterize TME interactions. We identify spatially distinct evolution of copy number alterations influencing local immune composition. Sub-regions with chromosome 7 gain display a relative lack of leukocyte infiltrate but evidence of neutrophil activation, recapitulated in The Cancer Genome Atlas (TCGA) samples, and associated with lack of response to IO across three clinical cohorts. Whether neutrophil activation represents cause or consequence of local tumor necrosis requires further study. Analyses of T-cell clonotypes reveal the presence of recurrent priming events manifesting in a dominant T-cell clonotype over many years. Our findings highlight the links between marked levels of genomic and immune heterogeneity within the physical space of a tumor, with implications for biomarker evaluation and immunotherapy response.
Asunto(s)
Genómica/métodos , Melanoma/metabolismo , Biomarcadores de Tumor/genética , Variaciones en el Número de Copia de ADN/genética , Humanos , Melanoma/genética , Mutación/genética , Activación Neutrófila/genética , Activación Neutrófila/fisiología , Microambiente Tumoral/genética , Microambiente Tumoral/fisiologíaRESUMEN
Sympathoadrenal stimulation may perturb results of endocrine tests performed on fractious horses. Sedation may be beneficial; however, perturbation of results may preclude useful information. Four experiments were designed to 1) determine the effects of epinephrine on insulin response to glucose (IR2G), 2) assess the effects of detomidine (DET), alone or combined with butorphanol (DET/BUT), on IR2G and glucose response to insulin (GR2I), and 3) assess the effects of BUT alone on IR2G. In Experiment 1, mares were administered saline or epinephrine (5 µg/kg BW) immediately before infusion of glucose (100 mg/kg BW). Glucose stimulated (P < .05) insulin release in controls at 5 minutes that persisted through 30 minutes; insulin was suppressed (P < .05) by epinephrine from 5 to 15 minutes, rising gradually through 30 minutes. Experiments 2 (IR2G) and 3 (GR2I) were conducted as triplicated 3 × 3 Latin squares with the following treatments: saline (SAL), DET, and DET/BUT (all administered at .01 mg/kg BW). Glucose stimulated (P < .05) insulin release that persisted through 30 minutes in SAL mares; DET and DET/BUT severely suppressed (P < .0001) the IR2G. Sedation did not affect resting glucose and had inconsistent effects on the GR2I when mares were treated with 50 mIU/kg BW recombinant human insulin. Butorphanol had no effect on IR2G. In conclusion, adrenergic agonists severely suppress the IR2G and cannot be used for sedation for this test. The use of DET did not alter the GR2I, and therefore may be useful for conducting this test in fractious horses.
Asunto(s)
Enfermedades de los Caballos , Resistencia a la Insulina , Animales , Butorfanol , Estudios Cruzados , Epinefrina , Femenino , Caballos , ImidazolesRESUMEN
OBJECTIVE: Our goal was to evaluate treatment attendance patterns, including both treatment completion and premature termination from treatment, for 2 evidence-based psychotherapies for major depressive disorder (MDD) delivered in a community mental health setting. We explored rates of premature termination across the course of treatment as well as the factors that predicted and moderated premature termination and treatment completion. METHOD: This investigation included 237 patients with MDD who participated in a noninferiority trial comparing short-term dynamic psychotherapy (DT) to cognitive therapy (CT). Patients in both conditions were offered 16 sessions of treatment and had up to 5 months to complete treatment. All patients completed an extensive self-report battery at treatment baseline as well as measures of the therapeutic alliance and opinions about treatment following Session 2. RESULTS: Premature termination from both treatments was high with 27% of patients discontinuing treatment very early after only an intake session or a single treatment session. Patients in CT were significantly more likely to terminate treatment prematurely, χ²(3) = 14.35, p = .002. Baseline physical health functioning, subthreshold psychotic symptoms, Session 2 ratings of agreement on tasks, and Session 2 ratings of treatment sensibility all independently predicted premature termination of services. Trauma history significantly moderated very early termination of treatment, χ²(3) = 10.26, p = .017, with patients with high trauma histories more likely to complete DT but terminate prematurely from CT. CONCLUSIONS: Very early termination from services was higher in CT compared with DT. Including techniques to improve engagement in both therapies and matching patients to treatment based on predictors/moderators may be effective ways to optimize treatment engagement. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Asunto(s)
Terapia Cognitivo-Conductual , Trastorno Depresivo Mayor/terapia , Salud Mental , Participación del Paciente , Psicoterapia Psicodinámica , Servicios Comunitarios de Salud Mental , Trastorno Depresivo Mayor/psicología , Femenino , Humanos , Masculino , Alianza TerapéuticaRESUMEN
Attention-deficit/hyperactivity disorder (ADHD) is a common brain developmental disorder in the general population that may be even more prevalent in elite athletes in certain sports. General population studies of ADHD are extensive and have reported on prevalence, symptoms, therapeutic and adverse effects of treatment and new clinical and research findings. However, few studies have reported on prevalence, symptoms and treatments of ADHD in elite athletes. This narrative review summarises the literature on symptoms, comorbidities, effects of ADHD on performance and management options for elite athletes with ADHD. The prevalence of ADHD in student athletes and elite athletes may be 7%-8%. The symptoms and characteristics of ADHD play a role in athletes' choice of a sport career and further achieving elite status. Proper management of ADHD in elite athletes is important for safety and performance, and options include pharmacologic and psychosocial treatments.
Asunto(s)
Atletas/psicología , Trastorno por Déficit de Atención con Hiperactividad/epidemiología , Rendimiento Atlético , Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Comorbilidad , Humanos , PrevalenciaRESUMEN
Five experiments were performed to test the hypothesis that α-melanocyte-stimulating hormone (MSH) is secreted in response to various stressors in horses similar to prolactin, growth hormone, and adrenocorticotropin (ACTH). There was considerable variation in resting concentrations of MSH and in the degree of stimulation in responders; thus all data sets were tested for heterogeneity of variance and corrected for as needed before analysis. In experiment 1, 12 mares were used in a switchback design to test the effect of a 2-minute exercise bout on MSH secretion. Plasma MSH concentrations were constant when mares were not exercised but increased (P < .05) immediately (2 minutes) after exercise and were still elevated 5 minutes later. In experiment 2, six mares were twitched for 2 minutes and six mares were not twitched. Twitching stimulated (P < .05) both MSH and ACTH relative to controls. Experiments 3, 4, and 5 tested the acute effects of intravenous injection of epinephrine at 5 µg/kg of body weight, intravenous injection of 100 µg substance P, and intramuscular injection of 10 mg prostaglandin-F2α in mares compared to controls (6, 5, and 6 mares per treatment group, respectively). Concentrations of MSH increased (P ≤ .05) after treatment in all three experiments. Plasma concentrations of ACTH also increased (P < .01) after administration of epinephrine and prostaglandin-F2α in experiments 3 and 5; plasma ACTH was not measured in experiment 1 or 4 because we have previously reported that exercise and substance P stimulate plasma ACTH concentrations. As hypothesized, MSH is secreted in response to various stimuli similar to that observed previously for prolactin, growth hormone, and ACTH.
Asunto(s)
Epinefrina , Sustancia P , Hormona Adrenocorticotrópica , Animales , Femenino , Hormona del Crecimiento , Caballos , Hormonas Estimuladoras de los MelanocitosRESUMEN
We present a method based on kinetic molecular theory that identifies reactions of various molecularities in molecular dynamics (MD) simulations of bulk gases. The method allows characterization of the thermodynamic conditions at which higher than bimolecular reactions are a factor in the mechanisms of complex gas-phase chemistry. Starting with Bodenstein's definition of termolecular collisions we derive analytical expressions for the frequency of higher molecularity collisions. We have developed a relationship for the ratio of the frequencies of termolecular to bimolecular collisions in terms of the temperature, density, and collision times. To demonstrate the method, we used ReaxFF in LAMMPS to carry out MD simulations for NVT ensembles of mixtures of H2-O2 over the density range 120.2-332.7 kg m-3 and temperature range 3000-5000 K. The simulations yield ReaxFF-based predictions of the relative importance of termolecular collisions O2···H2···O2 and bimolecular collisions O2···H2 in the early chemistry of hydrogen combustion.
RESUMEN
The objectives of this study were to determine the concentrations of reproductive and metabolic hormones during the peripubertal period and to assess their relationship with testicular development and body fat deposition. Blood samples were collected from 23 healthy Standardbred colts every four weeks for twelve months. Colts were weighed monthly, and percent of body fat and testicular volume estimated by ultrasound. Onset of puberty was determined as the month when testosterone was two standard deviations above the previous mean. Plasma FSH, LH, leptin, estradiol-17ß, androstenedione, IGF-1, insulin, inhibin-A, and inhibin-B were analyzed for a seven month peripubertal period. Spring born Standardbred colts underwent puberty at 13 months of age; onset of puberty coincided with exponential testicular growth but did not coincide with an increase in cutaneous body fat deposition or leptin (pâ¯>â¯0.05). Plasma inhibin-B concentrations were significantly increased in the postpubertal period (pâ¯<â¯0.05), but no increase was seen in inhibin-A, androstenedione, FSH, LH, or estradiol-17ß. In conclusion, the rise in testosterone and subsequent onset of puberty coincides with rapid testicular growth but is not correlated with an increase in gonadotropins, IGF-1, cutaneous body fat or leptin in the horse.
Asunto(s)
Caballos/metabolismo , Maduración Sexual , Androstenodiona/sangre , Animales , Distribución de la Grasa Corporal , Sistema Endocrino/crecimiento & desarrollo , Estradiol/sangre , Hormona Folículo Estimulante/sangre , Caballos/crecimiento & desarrollo , Inhibinas/sangre , Insulina/sangre , Factor I del Crecimiento Similar a la Insulina/metabolismo , Leptina/metabolismo , Hormona Luteinizante/sangre , Masculino , Tamaño de los Órganos , Testículo/anatomía & histología , Testículo/crecimiento & desarrolloRESUMEN
This experiment assessed the hormonal production, secretory aspects, and changes in luteinizing hormone (LH) receptor gene expression of early induced ovulatory-sized follicles relative to the first ovulatory-sized follicles occurring naturally in the spring. Anovulatory mares were treated on January 21 with (1) 50 mg of estradiol cypionate (ECP, n = 8) alone or (2) with ECP followed by two 3-g sulpiride injections (n = 8), 5 and 12 days later. Half of each group also received complete follicle ablation via transvaginal aspiration before ECP treatment. Ovaries were scanned regularly until detection of a 32-35 mm follicle; follicular fluid was recovered via aspiration for analysis of hormonal concentrations. Blood was collected regularly to characterize plasma prolactin, LH, follicle stimulating hormone, progesterone, and estradiol concentrations. Mean date to first 35-mm follicle was earlier (P < .05) in sulpiride-treated mares: five of eight (63%) responded within 28 days of the first sulpiride injection. Ablation did not affect ovarian response. Plasma prolactin was stimulated (P < .0001) in ECP-sulpiride-treated mares for 16 days but did not dictate ovarian response. Estradiol stimulated plasma LH (P < .05), which was higher (P < .05) in treated mares that responded. There was no effect of treatment or ablation on follicular fluid concentrations of estradiol, progesterone, leptin, or insulin-like growth factor 1 or on LH receptor gene expression. These latter similarities indicate that ECP-sulpiride early induced follicles have apparently reached a degree of maturity equivalent to naturally occurring ovulatory-sized follicles later in the spring.
RESUMEN
Four experiments assessed factors affecting prolactin responses to sulpiride administration in horses. Experiment 1 compared the efficacy of the (-) enantiomer of sulpiride to that of the commonly used (+/-) racemic mixture. Mares were used in an 8 × 8 Latin square to compare the prolactin responses to four doses of levosulpiride to four corresponding doses of the racemic mixture at twice the dose. Responses at each dose indicated equal and similar (P > .1) responses. Experiment 2 compared the efficacy of 1 gram of orally administered racemic sulpiride to 100 mg of intramuscularly injected sulpiride in oil in mares primed with 50 mg of estradiol cypionate (ECP). Prolactin responses in groups receiving sulpiride were robust but similar in magnitude with minor differences in timing. In experiment 3, ECP-primed geldings received subcutaneous injections of 1.8 grams racemic sulpiride in vegetable shortening in one of three sites: the neck, the back below the withers, or the lower girth region; control geldings received no sulpiride. Prolactin responses to sulpiride lasted a minimum of 96 hours. In experiment 4, prolactin responses to 3 g of racemic sulpiride in vegetable shortening were compared to similar injections (3 g) in 5 mL of sucrose acetate isobutyrate (SAIB; SucroMate) or just SAIB (control) in ECP-primed geldings. Controls had no prolactin response to SucroMate, whereas both treatment groups had extended prolactin responses lasting at least 10 days. It is concluded that prolactin responses to sulpiride in horses can be greatly extended by using hydrophobic vehicles like vegetable shortening or SAIB.
RESUMEN
We present a generalization of Tolman's concept of activation energy applicable to thermal and non-thermal reactions in molecular dynamics simulations of reactions in bulk gases. To illustrate the applicability of the method, molecular dynamics calculations were carried out for the NVT ensemble to determine the activation energies of O2 + H2 â H + HO2 and 2O2 + H2 â 2HO2 from MD simulation results for [H2]/[O2] = 1 at 3000 K using the reactive force field, ReaxFF. Assuming local thermodynamic equilibrium, we define the reaction cluster local energy, the energy of the atoms participating in an individual reaction, which is conserved. The generalized Tolman activation energy (GTEa) approach is applicable to reactions of any molecularity. Although we have applied GTEa for thermal conditions, it is applicable to chemistry occurring under non-thermal conditions because it rests upon local rather than global equilibrium. We have defined the transition configurations, unique points that define a seam separating reactants and products at which the local energies of the reactants and products become equal.
RESUMEN
Climate change is expected to alter precipitation patterns. Droughts may become longer and more frequent, and the timing and intensity of precipitation may change. We tested how shifting precipitation patterns, both seasonally and by frequency of events, affects soil nitrogen availability, plant biomass and diversity in a shrub-steppe temperate grassland along a natural productivity gradient in Lac du Bois Grasslands Protected Area near Kamloops, British Columbia, Canada. We manipulated seasonal watering patterns by either exclusively watering in the spring or the fall. To simulate spring precipitation we restricted precipitation inputs in the fall, then added 50% more water than the long term average in the spring, and vice-versa for the fall precipitation treatment. Overall, the amount of precipitation remained roughly the same. We manipulated the frequency of rainfall events by either applying water weekly (frequent) or monthly (intensive). After 2 years, changes in the seasonality of watering had greater effects on plant biomass and diversity than changes in the frequency of watering. Fall watering reduced biomass and increased species diversity, while spring watering had little effect. The reduction in biomass in fall watered treatments was due to a decline in grasses, but not forbs. Plant available N, measured by Plant Root Simulator (PRS)-probes, increased from spring to summer to fall, and was higher in fall watered treatments compared to spring watered treatments when measured in the fall. The only effect observed due to frequency of watering events was greater extractable soil N in monthly applied treatments compared to weekly watering treatments. Understanding the effects of changing precipitation patterns on grasslands will allow improved grassland conservation and management in the face of global climatic change, and here we show that if precipitation is more abundant in the fall, compared to the spring, grassland primary productivity will likely be negatively affected.
Asunto(s)
Cambio Climático , Pradera , Modelos Biológicos , Plantas , Estaciones del Año , Agua , Colombia BritánicaRESUMEN
IMPORTANCE: Dynamic psychotherapy (DT) is widely practiced in the community, but few trials have established its effectiveness for specific mental health disorders relative to control conditions or other evidence-based psychotherapies. OBJECTIVE: To determine whether DT is not inferior to cognitive therapy (CT) in the treatment of major depressive disorder (MDD) in a community mental health setting. DESIGN, SETTING, AND PARTICIPANTS: From October 28, 2010, to July 2, 2014, outpatients with MDD were randomized to treatment delivered by trained therapists. Twenty therapists employed at a community mental health center in Pennsylvania were trained by experts in CT or DT. A total of 237 adult outpatients with MDD seeking services at this site were randomized to 16 sessions of DT or CT delivered across 5 months. Final assessment was completed on December 9, 2014, and data were analyzed from December 10, 2014, to January 14, 2016. INTERVENTIONS: Short-term DT or CT. MAIN OUTCOMES AND MEASURES: Expert blind evaluations with the 17-item Hamilton Rating Scale for Depression. RESULTS: Among the 237 patients (59 men [24.9%]; 178 women [75.1%]; mean [SD] age, 36.2 [12.1] years) treated by 20 therapists (19 women and 1 man; mean [SD] age, 40.0 [14.6] years), 118 were randomized to DT and 119 to CT. A mean (SD) difference between treatments was found in the change on the Hamilton Rating Scale for Depression of 0.86 (7.73) scale points (95% CI, -0.70 to 2.42; Cohen d, 0.11), indicating that DT was statistically not inferior to CT. A statistically significant main effect was found for time (F1,198 = 75.92; P = .001). No statistically significant differences were found between treatments on patient ratings of treatment credibility. Dynamic psychotherapy and CT were discriminated from each other on competence in supportive techniques (t120 = 2.48; P = .02), competence in expressive techniques (t120 = 4.78; P = .001), adherence to CT techniques (t115 = -7.07; P = .001), and competence in CT (t115 = -7.07; P = .001). CONCLUSIONS AND RELEVANCE: This study suggests that DT is not inferior to CT on change in depression for the treatment of MDD in a community mental health setting. The 95% CI suggests that the effects of DT are equivalent to those of CT. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01207271.
Asunto(s)
Terapia Cognitivo-Conductual , Centros Comunitarios de Salud Mental , Trastorno Depresivo Mayor/terapia , Psicoterapia Psicodinámica , Adulto , Trastorno Depresivo Mayor/diagnóstico , Trastorno Depresivo Mayor/psicología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pennsylvania , Resultado del TratamientoRESUMEN
This study investigated how hydrophobicity, solubility and the concentration of flavour compounds related to inclusion complexation by dispersed native high amylose maize starch (HAMS). The effect of native lipid on flavour retention and the effect of time (one day to one month) on flavour retention and precipitated starch yield was also examined. Flavour-starch complexation was dependent on the flavour compound hydrophobicity, the flavour concentration in a dose-dependent manner and also influenced by time (increased during storage). Flavour composition also influenced starch complexation; no flavour complexes were reported with limonene by itself but were observed when added in binary flavour mixtures with menthone or thymol. Furthermore, no difference in flavour retention was observed for native and lipid-free starch dispersions. In summary, flavour inclusion complexes with HAMS exhibited cooperativity-type binding behaviour; with a critical ligand concentration needed for a stable physical association between flavour compounds and HAMS.
Asunto(s)
Amilosa/química , Almidón/química , Agua/química , Difracción de Rayos X/métodos , Zea mays/química , AromatizantesRESUMEN
Public health advocates, government agencies, and commercial organizations increasingly use nutritional science to guide food choice and diet as a way of promoting health, preventing disease, or marketing products. We argue that in many instances such references to nutritional science can be characterized as nutritional scientism. We examine three manifestations of nutritional scientism: (1) the simplification of complex science to increase the persuasiveness of dietary guidance, (2) superficial and honorific references to science in order to justify cultural or ideological views about food and health, and (3) the presumption that nutrition is the primary value of food. This paper examines these forms of nutritional scientism in the context of biopolitics to address bioethical concerns related to the misuse of scientific evidence to make claims regarding the effect of diet on health. We argue that nutritional scientism has ethical implications (i) for individual responsibility and freedom, (ii) concerning iatrogenic harm, and (iii) for well-being.
Asunto(s)
Disciplinas de las Ciencias Biológicas , Enfermedades Carenciales/dietoterapia , Enfermedades Carenciales/diagnóstico , Dieta , Alimentos , Promoción de la Salud , Política Nutricional , Formulación de Políticas , Salud Pública , Responsabilidad Social , Ácido Ascórbico/historia , Ácido Ascórbico/aislamiento & purificación , Deficiencia de Ácido Ascórbico/diagnóstico , Deficiencia de Ácido Ascórbico/dietoterapia , Libertad , Salud , Conductas Relacionadas con la Salud , Historia del Siglo XIX , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Enfermedad Iatrogénica , Política Nutricional/historia , Política Nutricional/tendencias , Salud Pública/ética , Salud Pública/métodos , Salud Pública/normas , Salud Pública/tendencias , Ingesta Diaria Recomendada/historia , Ingesta Diaria Recomendada/legislación & jurisprudencia , Estados UnidosRESUMEN
Surface-initiated melting of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB), a triclinic molecular crystal, was investigated using molecular dynamics simulations. Simulations were performed for the three principal crystallographic planes exposed to vacuum, with the normal vectors to the planes given by b × c, c × a, and a × b (where a, b, and c define the edge vectors of the unit cell), denoted as (100), (010), and (001), respectively. The best estimate of the normal melting temperature for TATB is 851 ± 5 K. The nature and extent of disordering of the crystal-vacuum interface depend on the exposed crystallographic face, with the (001) face exhibiting incomplete melting and superheating. This is attributed to the anisotropy of the inter-molecular hydrogen bonding and the propensity of the crystal to form stacking faults in directions approximately perpendicular to the (100) and (010) faces. For all three crystal orientations, formation of molecular vacancies in the lattice at the crystal-vacuum (or crystal-quasi-liquid layer) interface precedes the complete loss of order at the interface.