RESUMEN
AIM : To study the effectiveness of concomitant atropine and glycopyrrolate infusion over atropine infusion in organophosphorus (OP) poisoning. METHODS : A prospective randomized study was carried out among 60 OP poisoned patients admitted to an emergency department of tertiary care hospital in south India. All patients admitted with acute OP poisoning were enrolled in the study. They were randomized into test group and control group of 30 patients each. Patients who received only atropine alone were randomized as control group and patients who received concomitant glycopyrrolate were enrolled in the test group. All patients were provided 1g pralidoxime every eighth hourly treatment. The severity was assessed using GCS, APACHE II, and PSS scores at admission. The outcomes were accessed in terms of intermediate syndrome, ventilation period, total dose and duration of atropine, atropine toxicity, incidence of pneumonia,hospitalization period and mortality.