Effect of intermittent normobaric hypoxia on kinetic properties of mitochondrial enzymes.

We studied the effect of intermittent normobaric hypoxia on the formation of adaptive signs and state of mitochondrial enzymes in the cerebral cortex of rats with different resistance to hypoxia. Kinetic parameters for mitochondrial enzymes in the substrate region of the respiratory chain of the cerebral cortex underwent various changes in low resistant and highly resistant rats over the first 2 h after 1-h intermittent normobaric hypoxia. Low resistant animals were characterized by more effective functioning of rotenone-sensitive NADH-cytochrome C reductase and succinate-cytochrome C reductase under conditions of increased reduction status of the cell. These features correlated with the increase in the general resistance of animals. Significant changes in kinetic properties of mitochondrial enzymes and signs of the development of resistance were not found in highly resistant rats. Reciprocal relations between mitochondrial enzyme complexes in the substrate region of the respiratory chain probably play a role of the signal regulatory mechanism, which mediates tissue-specific and general resistance of rats under conditions of intermittent normobaric hypoxia. These effects did not depend on oxygenation of the inhaled gas mixture during the inter-hypoxic period.

[The role of free radical processes in the uterus--placenta--fetus system during adaptation to interval hypoxia]. / Rol' svobodnoradikal'nykh protsessov v sistem mat'--platsenta--plod pri adaptatsii k interval'noi gipoksii.

The impact of adaptation to interval normobaric hypoxia on free radical-mediated processes was studied in pregnant women at abdominal delivery. The content of the material reacting with thiobarbituric acid, the generation of active oxygen forms (peroxide-induced, luminol-dependent chemiluminescence) and superoxide scavenging activity were evaluated in maternal venous plasma, umbilical plasma, and placenta. The findings suggest that interval hypoxic training of pregnant women produces antioxidative effects not only on the maternal organism, but also on the fetus and placenta. Thus, regulation and optimization of free radical-mediated processes in the mother-placenta-fetus system are a mechanism underlying the beneficial effects of interval hypoxic training.

[Intersensory correlations in diabetic neuropathy during adaptation to intervalic normobaric hypoxia]. / Mezhsensornye vzaimootnosheniia pri diabeticheskoi neiropatii v protsesse adaptatsii k interval'noi normobaricheskoi gipoksii.

The state of vibration sensitivity and of gustatory perception as well as the influence of interval hypoxic training on these indices were estimated in 21 patients with insulin-independent diabetes mellitus (IIDM) without neuropathic manifestations, in 21 analogous patients with neuropathic manifestations and in 16 individuals with neuropathies of nondiabetic genesis. The improvement of indices studied was observed in patients with neuropathies. Interval hypoxic training may be recommended for the treatment of distal neuropathies including the patients with IIDM in the state of compensation.