RESUMEN
Adult-onset Still's disease (AOSD) is an uncommon inflammatory condition characterised by a triad of fevers, arthralgias and a salmon-coloured rash. It is also strongly associated with high ferritin levels, whose role in its pathogenesis is not entirely clear. Central nervous system (CNS) manifestations are exceedingly rare in this disease, accounting for only a handful of reported cases. Herein, we describe a case of a 63-year-old woman who developed new-onset psychiatric symptoms in the months preceding her diagnosis. 2 months after her diagnosis, she experienced an exacerbation of psychiatric symptoms followed by new-onset seizures in conjunction with an acute lung infection. In addition, we discuss two other previously reported cases of AOSD patients with psychiatric symptoms as their initial presentation.
Asunto(s)
Agresión , Manía/inmunología , Conducta Paranoide/inmunología , Convulsiones/inmunología , Enfermedad de Still del Adulto/diagnóstico , Anticonvulsivantes/administración & dosificación , Artralgia/inmunología , Diagnóstico Diferencial , Electroencefalografía , Femenino , Fiebre/inmunología , Glucocorticoides/uso terapéutico , Humanos , Levetiracetam/administración & dosificación , Lorazepam/administración & dosificación , Manía/diagnóstico , Manía/tratamiento farmacológico , Metotrexato/uso terapéutico , Persona de Mediana Edad , Conducta Paranoide/diagnóstico , Conducta Paranoide/tratamiento farmacológico , Convulsiones/tratamiento farmacológico , Enfermedad de Still del Adulto/complicaciones , Enfermedad de Still del Adulto/tratamiento farmacológico , Enfermedad de Still del Adulto/inmunología , Resultado del TratamientoAsunto(s)
Atetosis/etiología , Infarto Cerebral/complicaciones , Corea/etiología , Accidente Cerebrovascular Isquémico/complicaciones , Anciano de 80 o más Años , Atetosis/tratamiento farmacológico , Infarto Cerebral/diagnóstico por imagen , Infarto Cerebral/tratamiento farmacológico , Corea/tratamiento farmacológico , Antagonistas de Dopamina/uso terapéutico , Femenino , Humanos , Accidente Cerebrovascular Isquémico/diagnóstico por imagen , Accidente Cerebrovascular Isquémico/tratamiento farmacológico , Risperidona/uso terapéutico , Tetrabenazina/análogos & derivados , Tetrabenazina/uso terapéuticoRESUMEN
We report the synthesis of [Mn(tacud)2](OTf)2 (1) (tacud = 1,4,8-triazacycloundecane), [Mn(tacd)2](OTf)2 (2) (tacd = 1,4,7-triazacyclodecane), and [Mn(tacn)2](OTf)2 (3) (tacn = 1,4,7-triazacyclononane). Electrochemical measurements on the MnIII/II redox couple show that complex 1 has the largest anodic potential of the set (E 1/2 = 1.16 V vs NHE, ΔE p = 106 mV) compared to 2 (E 1/2 = 0.95 V, ΔE p = 108 mV) and 3 (E 1/2 = 0.93 V, ΔE p = 96 mV). This is due to the fact that 1 has the fewest 5-membered chelate rings and thus is least stabilized. Magnetic studies of 1-3 revealed that all complexes remain high spin throughout the temperature range investigated (2 - 300 K). X-band EPR investigations in methanol glass indicated that the manganese(II) centers for 2 and 3 resided in a more distorted octahedral geometric configuration compared to 1. To ease spectral interpretation and extract ZFS parameters, we performed high-frequency high-field EPR (HFEPR) at frequencies above 200 GHz and a field of 7.5 T. Simulation of the spectral data yielded g = 2.0013 and D = -0.031 cm-1 for 1, g = 2.0008, D = -0.0824 cm-1, |E/D| = 0.12 for 2, and g = 2.00028, D = -0.0884 cm-1 for 3. These results are consistent with 3 possessing the most distorted geometry. Calculations (PBE0/6-31G(d)) were performed on 1-3. Results show that 1 has the largest HOMO-LUMO gap energy (6.37 eV) compared to 2 (6.12 eV) and 3 (6.26 eV). Complex 1 also has the lowest HOMO energies indicating higher stability.