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1.
Pediatr Blood Cancer ; 65(7): e27064, 2018 07.
Artículo en Inglés | MEDLINE | ID: mdl-29630779

RESUMEN

PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy, in need of effective treatment. Preliminary data support the efficacy of scrambler therapy (ST), a noninvasive cutaneous electrostimulation device, in adults with CIPN. We test the efficacy, safety, and durability of ST for neuropathic pain in adolescents with CIPN. PATIENTS AND METHODS: We studied nine pediatric patients with cancer and CIPN who received ST for pain control. Each patient received 45-min daily sessions for 10 consecutive days as a first step, but some of them required additional treatment. RESULTS: Pain significantly improved comparing Numeric Rate Scale after 10 days of ST (9.22 ± 0.83 vs. 2.33 ± 2.34; P < 0.001) and at the end of the optimized cycle (EOC) (9.22 ± 0.83 vs. 0.11 ± 0.33, P < 0.001). The improvement in quality of life was significantly reached on pain interference with general activity (8.67 ± 1.66 vs. 3.33 ± 2.12, P < 0.0001), mood (8.33 ± 3.32 vs. 2.78 ± 2.82, P < 0.0005), walking ability (10.00 vs. 2.78 ± 1.22, P < 0.0001), sleep (7.56 ± 2.24 vs. 2.67 ± 1.41, P < 0.001), and relations with people (7.89 ± 2.03 vs. 2.11 ± 2.03, P < 0.0002; Lansky score 26.7 ± 13.2 vs. 10 days of ST 57.8 ± 13.9, P < 0.001; 26.7 ± 13.2 vs. EOC 71.1 ± 16.2, P < 0.001). CONCLUSION: Based on these preliminary data, ST could be a good choice for adolescents with CIPN for whom pain control is difficult. ST caused total relief or dramatic reduction in CIPN pain and an improvement in quality of life, durable in follow-up. It caused no detected side effects, and can be retrained successfully. Further larger studies should be performed to confirm our promising preliminary data in pediatric patients with cancer.


Asunto(s)
Antineoplásicos/efectos adversos , Neuralgia/inducido químicamente , Neuralgia/terapia , Estimulación Eléctrica Transcutánea del Nervio/métodos , Adolescente , Niño , Femenino , Humanos , Masculino , Neoplasias/tratamiento farmacológico , Manejo del Dolor/métodos
2.
Pain Pract ; 16(7): E103-9, 2016 09.
Artículo en Inglés | MEDLINE | ID: mdl-27370908

RESUMEN

BACKGROUND: Complex regional pain syndrome (CRPS) is a disorder that is often challenging to treat and can be associated with a prolonged course of severe pain. Therapy of CRPS remains controversial; the pain often can be very difficult to control, and treatment includes medications, physical therapy, regional anesthesia, and neuromodulation. AIM: We evaluated Scrambler Therapy(®) (ST) in terms of efficacy, safety, and durability of treatment effect in patients suffering from CRPS. MATERIALS AND METHODS: We report the response to ST in four patients with CRPS referred to the Pain Center of Bambino Gesù Children's Hospital. The patients previously did not respond to conventional and nonconventional medical treatments. RESULTS: The treatment with ST was found effective in all four of our patients; they obtained pain relief for long periods and an improvement in their quality of life. We observed a progressive improvement with complete disappearance of neuropathic pain. Patients also reported a muscle strength increase that allowed them to resume normal daily activities. DISCUSSION AND CONCLUSION: We conclude that ST may offer a therapeutic opportunity for patients with neuropathic pain resulting from CRPS, without side effects and with minimal discomfort during treatment. The observed pain relief indicates that ST could be an effective option for such patients.


Asunto(s)
Síndromes de Dolor Regional Complejo/terapia , Terapia por Estimulación Eléctrica/métodos , Manejo del Dolor/métodos , Femenino , Humanos , Masculino , Dimensión del Dolor/métodos , Calidad de Vida
3.
Acta Paediatr ; 105(5): e200-8, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-26792256

RESUMEN

AIM: Italian national guidelines on pain management were published in 2010, but there is little information on how effective pain management is in paediatric emergency care, with other countries reporting poor levels. Using headache as an indicator, we described pain assessment in Italian emergency departments and identified predictors of algometric scale use. METHODS: All Italian paediatric and maternal and child hospitals participated, plus four general hospitals. Data on all children aged 4-14 years admitted during a one-month period with headache as their chief complaint were abstracted from clinical records. Multivariable analyses identified predictors of algometric assessment, taking into account the cluster study design. RESULTS: We studied 470 admissions. During triage, pain was assessed using a standardised scale (41.5%), informally (15.5%) or was not recorded (42.9%). Only 32.1% of the children received analgesia in the emergency department. The odds ratios for predictors of algometric assessment were non-Italian nationality (3.6), prehospital medication (1.8), admission to a research hospital (7.3) and a more favourable nurses-to-admissions ratio of 10.8 for the highest versus lowest tertile. CONCLUSION: Despite national guidelines, paediatric pain assessment in Italian emergency care was suboptimal. Hospital variables appeared to be stronger predictors of adequate assessment than patient characteristics.


Asunto(s)
Servicios Médicos de Urgencia/normas , Adhesión a Directriz/estadística & datos numéricos , Cefalea/diagnóstico , Dimensión del Dolor/estadística & datos numéricos , Indicadores de Calidad de la Atención de Salud/estadística & datos numéricos , Triaje/normas , Adolescente , Niño , Preescolar , Servicios Médicos de Urgencia/métodos , Servicios Médicos de Urgencia/estadística & datos numéricos , Servicio de Urgencia en Hospital/normas , Femenino , Hospitales Generales/normas , Hospitales Pediátricos/normas , Humanos , Italia , Masculino , Dimensión del Dolor/métodos , Dimensión del Dolor/normas , Pediatría , Guías de Práctica Clínica como Asunto , Estudios Retrospectivos , Triaje/métodos , Triaje/estadística & datos numéricos
4.
BMC Pediatr ; 13: 139, 2013 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-24020369

RESUMEN

BACKGROUND: Pain experienced by children in emergency departments (EDs) is often poorly assessed and treated. Although local protocols and strategies are important to ensure appropriate staff behaviours, few studies have focussed on pain management policies at hospital or department level. This study aimed at describing the policies and reported practices of pain assessment and treatment in a national sample of Italian pediatric EDs, and identifying the assocoated structural and organisational factors. METHODS: A structured questionnaire was mailed to all the 14 Italian pediatric and maternal and child hospitals and to 5 general hospitals with separate pediatric emergency room. There were no refusals. Information collected included the frequency and mode of pain assessment, presence of written pain management protocols, use of local anaesthetic (EMLA cream) before venipuncture, and role of parents. General data on the hospital and ED were also recorded. Multiple Correspondence Analysis was used to explore the multivariable associations between the characteristics of hospitals and EDs and their pain management policies and practices. RESULTS: Routine pain assessment both at triage and in the emergency room was carried out only by 26% of surveyed EDs. About one third did not use algometric scales, and almost half (47.4%) did not have local protocols for pain treatment. Only 3 routinely reassessed pain after treatment, and only 2 used EMLA. All EDs allowed parents' presence and most (17, 89.9%) allowed them to stay when painful procedures were carried out. Eleven hospitals (57.9%) allowed parents to hold their child during blood sampling. Pediatric and maternal and child hospitals, those located in the North of Italy, equipped with medico-surgical-traumatological ED and short stay observation, and providing full assessment triage over 24 hours were more likely to report appropriate policies for pain management both at triage and in ER. A nurses to admissions ratio ≥ median was associated with better pain management at triage. CONCLUSIONS: Despite availability of national and international guidelines, pediatric pain management is still sub-optimal in Italian emergency departments. Multifaceted strategies including development of local policies, staff educational programs, and parental involvement in pain assessment should be carried out and periodically reinforced.


Asunto(s)
Servicios Médicos de Urgencia/normas , Manejo del Dolor/métodos , Dimensión del Dolor/métodos , Pediatría/métodos , Adolescente , Análisis de Varianza , Niño , Preescolar , Servicios Médicos de Urgencia/estadística & datos numéricos , Servicio de Urgencia en Hospital , Femenino , Adhesión a Directriz , Humanos , Lactante , Italia , Masculino , Manejo del Dolor/normas , Manejo del Dolor/estadística & datos numéricos , Dimensión del Dolor/normas , Pediatría/normas , Pediatría/estadística & datos numéricos , Encuestas y Cuestionarios
5.
J Vasc Access ; 12(4): 321-4, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21553391

RESUMEN

PURPOSE: Recent reports suggest that ultrasound-guided central venous cannulation may also be safe and effective in infants. This study aimed to evaluate the success and complications rate of this technique in infants weighing less than 5 kg. METHODS: We studied 45 infants, weighing less than 5 kg (mean weight: 2.9 ± 1.1 kg, median: 3.1) needing a central venous access for intensive care treatment. In all patients, venous access was obtained by ultrasound-guided cannulation of the internal jugular vein (IJV). RESULTS: Central venous cannulation was successful in all 45 infants. The right internal jugular vein (IJV) was used in most cases (92%). The IJV was antero-lateral to the carotid artery in 66% of patients, lateral in 28% and anterior in 6%. Although we recorded 10 complications (22.2%), only one was clinically relevant (one pneumothorax). The other complications were repeated venipunctures (n=4), kinking of the guidewire (n=3) and local venous hematomas (n=2). The time required for completing the procedure was 7 ± 4.3 min, while the mean time of central venous catheter permanence was 5.5 ± 8 days. There was a negative correlation between the patient's weight and the time needed for cannulation (p<0.01). Complications occurred in infants with a lower body weight (p<0.01). CONCLUSIONS: Our experience suggests that ultrasound-guided central vein cannulation can be performed by well-trained physicians in infants weighing less than 5 kg without relevant risks.


Asunto(s)
Peso Corporal , Cateterismo Venoso Central/métodos , Venas Yugulares/diagnóstico por imagen , Radiografía Intervencional , Cateterismo Venoso Central/efectos adversos , Estudios de Factibilidad , Humanos , Lactante , Recién Nacido , Unidades de Cuidado Intensivo Pediátrico , Italia , Selección de Paciente , Medición de Riesgo , Factores de Riesgo , Factores de Tiempo , Ultrasonografía
6.
Intensive Care Med ; 37(1): 124-31, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20878387

RESUMEN

PURPOSE: In critically ill adults, a reduction in the extravascular lung water index (EVLWi) decreases time on mechanical ventilation and improves survival. The purpose of this study is to assess the prognostic value of EVLWi in critically ill children with acute respiratory failure and investigate its relationships with PaO(2), PaO(2)/FiO(2) ratio, A-aDO(2), oxygenation index (OI), mean airway pressure, cardiac index, pulmonary permeability, and percent fluid overload. METHODS: Twenty-seven children admitted to PICU with acute respiratory failure received volumetric hemodynamic and blood gas monitoring following initial stabilization and every 4 h thereafter, until discharge from PICU or death. All patients are grouped in two categories: nonsurvivors and survivors. RESULTS: Children with a fatal outcome had higher values of EVLWi on admission to PICU, as well as higher A-aDO(2) and OI, and lower PaO(2) and PaO(2)/FIO(2) ratio. After 24 h EVLWi decreased significantly only in survivors. As a survival indicator, EVLWi has good sensitivity and good specificity. Changes in EVLWi, OI, and mean airway pressure had a time-dependent influence on survival that proved significant according to the Cox test. Survivors spent fewer hours on mechanical ventilation. We detected a correlation of EVLWi with percent fluid overload and pulmonary permeability. CONCLUSIONS: Like OI and mean airway pressure, EVLWi on admission to PICU is predictive of survival and of time needed on mechanical ventilation.


Asunto(s)
Agua Pulmonar Extravascular , Insuficiencia Respiratoria/mortalidad , Insuficiencia Respiratoria/fisiopatología , Enfermedad Aguda , Niño , Preescolar , Enfermedad Crítica , Femenino , Humanos , Lactante , Masculino , Pronóstico , Tasa de Supervivencia
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